Publications from amfAR Grantees and Fellows
Click here for publications prior to 2017.
Introduction
Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff.
February 2022
The HIV-1 proviral landscape reveals Nef contributes to HIV-1 persistence in effector memory CD4+ T-cells.
Duette G, Hiener B, Morgan H, Mazur FG, Mathivanan V, Horsburgh BA, Fisher K, Tong O, Lee E, Ahn H, Shaik A, Fromentin R, Hoh R, Bacchus-Souffan C, Nasr N, Cunningham A, Hunt PW, Chomont N, Turville SG, Deeks SG, Kelleher AD, Schlub TE, Palmer S. J Clin Invest. 2022 Feb 8:e154422. doi: 10.1172/JCI154422.
January 2022
From structure to sequence: Antibody discovery using cryoEM.
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB. Sci Adv. 2022 Jan 21;8(3):eabk2039.
Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda.
Joussef-Piña S, Nankya I, Nalukwago S, Baseke J, Rwambuya S, Winner D, Kyeyune F, Chervenak K, Thiel B, Asaad R, Dobrowolski C, Luttge B, Lawley B, Kityo CM, Boom WH, Karn J, Quiñones-Mateu ME. Retrovirology. 2022 Jan 15;19(1):1.
ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV.
Daskou M, Mu W, Sharma M, Vasilopoulos H, Heymans R, Ritou E, Rezek V, Hamid P, Kossyvakis A, Sen Roy S, Grijalva V, Chattopadhyay A, Kitchen SG, Fogelman AM, Reddy ST, Kelesidis T. PLoS Pathog. 2022 Jan 7;18(1):e1010160.
Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy.
Chiu CY, Chang JJ, Dantanarayana AI, Solomon A, Evans VA, Pascoe R, Gubser C, Trautman L, Fromentin R, Chomont N, McMahon JH, Cameron PU, Rasmussen TA, Lewin SR. J Immunol. 2022 Jan 1;208(1):54-62.
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses.
Einkauf KB, Osborn MR, Gao C, Sun W, Sun X, Lian X, Parsons EM, Gladkov GT, Seiger KW, Blackmer JE, Jiang C, Yukl SA, Rosenberg ES, Yu XG, Lichterfeld M. Cell. 2022 Jan 20;185(2):266-282.
Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial.
Henning Gruell*, Jesper D Gunst*, Yehuda Z Cohen*, Marie H Pahus, Jakob J Malin, Martin Platten, Katrina G Millard, Martin Tolstrup, R Brad Jones, Winnifer D Conce Alberto, Julio C C Lorenzi, Thiago Y Oliveira, Tim Kümmerle, Isabelle Suárez, Cecilia Unson-O’Brien, Lilian Nogueira, Rikke Olesen, Lars Østergaard, Henrik Nielsen, Clara Lehmann, Michel C Nussenzweig, Gerd Fätkenheuer, Florian Klein, Marina Caskey, Ole S Søgaard. Lancet Microbe. Published Online January 24, 2022 https://doi.org/10.1016/ S2666-5247(21)00239-1.
December 2021
Techniques for Developing and Assessing Immune Responses Induced by Synthetic DNA Vaccines for Emerging Infectious Diseases.
Xu Z, Ho M, Bordoloi D, Kudchodkar S, Khoshnejad M, Giron L, Zaidi F, Jeong M, Roberts CC, Park YK, Maslow J, Abdel-Mohsen M, Muthumani K. Methods Mol Biol. 2022;2410:229-263.
Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers.
Lian X, Gao C, Sun X, Jiang C, Einkauf KB, Seiger KW, Chevalier JM, Yuki Y, Martin M, Hoh R, Peluso MJ, Carrington M, Ruiz-Mateos E, Deeks SG, Rosenberg ES, Walker BD, Lichterfeld M, Yu XG.Sci Transl Med. 2021 Dec 15;13(624):eabl4097.
READ MORE
November 2021
Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo.
Cummins NW, Baker J, Chakraborty R, Dean PG, Garcia-Rivera E, Krogman A, Kumar S, Kuzmichev YV, Laird GM, Landay A, Lichterfeld M, Mahmood M, Martinson J, Maynes M, Natesampillai S, Rajkumar V, Rassadkina Y, Ritter KD, Rivera CG, Rizza SA, Subramanian K, Tande AJ, Wonderlich ER, Whitaker JA, Zeuli J, Badley AD. EClinicalMedicine. 2021 Nov 29;42:101225.
Rebound HIV viremia with meningoencephalitis following antiretroviral therapy interruption after allogeneic bone marrow transplant.
Capoferri AA, Redd AD, Gocke CD, Clark LR, Quinn TC, Ambinder RF, Durand CM. J Acquir Immune Defic Syndr. 2021 Nov 8. doi: 10.1097/QAI.0000000000002862.
READ MORE
Multiscale Approach for Computing Gated Ligand Binding from Molecular Dynamics and Brownian Dynamics Simulations.
Sadiq SK, Muñiz Chicharro A, Friedrich P, Wade RC. J Chem Theory Comput. 2021 Nov 5. doi: 10.1021/acs.jctc.1c00673.
Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer.
Zhang S, Wang K, Wang WL, Nguyen HT, Chen S, Lu M, Go EP, Ding H, Steinbock RT, Desaire H, Kappes JC, Sodroski J, Mao Y.J Virol. 2021 Nov 23;95(24):e0052921.
October 2021
Are We Hitting the Target? HIV Pre-Exposure Prophylaxis from 2012 to 2020 in the OPERA Cohort.
Mounzer KC, Fusco JS, Hsu RK, Brunet L, Vannappagari V, Frost KR, Shaefer MS, Rinehart A, Rawlings K, Fusco GP. AIDS Patient Care STDS. 2021 Oct 4. doi: 10.1089/apc.2021.0064.
Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation.
Nguyen K, Dobrowolski C, Shukla M, Cho WK, Luttge B, Karn J. PLoS Pathog. 2021 Oct 21;17(10):e1010014.
READ MORE
September 2021
Functional impairment of HIV-specific CD8(+) T cells precedes aborted spontaneous control of viremia.
Collins DR, Urbach JM, Racenet ZJ, Arshad U, Power KA, Newman RM, Mylvaganam GH, Ly NL, Lian X, Rull A, Rassadkina Y, Yanez AG, Peluso MJ, Deeks SG, Vidal F, Lichterfeld M, Yu XG, Gaiha GD, Allen TM, Walker BD. Immunity. 2021 Sep 2:S1074-7613
READ MORE
The clonal expansion dynamics of the HIV-1 reservoir: mechanisms of integration site-deopendent proliferation and HIV-1 persistence.
Yang-Hui Jimmy Yeh, Kerui Yang, Anya Razmi, Ya-Chi Ho. Viruses. 2021 Sep 13(9)i:1858.
A systems approach to elucidate personalized mechanistic complexities of antibody-Fc receptor activation post-vaccination.
Lemke MM, McLean MR, Lee CY, Lopez E, Bozich ER, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kratochvil S, Wines BD, Hogarth PM, Kent SJ, Chung AW, Arnold KB.Cell Rep Med. 2021 Sep 1;2(9):100386.
August 2021
Intravenous bamlanivimab use associates with reduced hospitalization in high-risk patients with mild to moderate COVID-19.
Ganesh R, Pawlowski CF, O'Horo JC, Arndt LL, Arndt RF, Bell S, Bierle DM, Destro Borgen M, Hanson S, Heyliger A, Larsen JL, Lenehan PJ, Orenstein R, Puranik A, Speicher LL, Tulledge-Scheitel SM, Venkatakrishnan AJ, Wilker CG, Badley AD, Razonable RR. J Clin Invest. 2021 Aug 19:151697. doi: 10.1172/JCI151697.
Intra- and extra-cellular environments contribute to the fate of HIV-1 infection.
Ratnapriya S, Harris M, Chov A, Herbert ZT, Vrbanac V, Deruaz M, Achuthan V, Engelman AN, Sodroski J, Herschhorn A. Cell Rep. 2021 Aug 31;36(9):109622.
Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein.
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, Torrents de la Peña A, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ. J Virol. 2021 Aug 10;95(17):e0009421. doi: 10.1128/JVI.00094-21.
READ MORE
July 2021
Association of transcriptomic signatures of inflammatory response with viral control after dendritic cell-based therapeutic vaccination in HIV-1 infecred individuals. Feher C, Pastor-Ibanez R, Leal L, Plana M, Arnedo M, van den Ham H-J, Andeweg AC, Gruters RA, Diez-Fuertes F, Alcami J, Aloy P, Garcia F. Vaccines.
Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women. Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA. J Int AIDS Soc. 2021 Jul;24(7):e25738.
READ MORE
June 2021
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV.
Giron LB, Palmer CS, Liu Q, Yin X, Papasavvas E, Sharaf R, Etemad B, Damra M, Goldman AR, Tang HY, Johnston R, Mounzer K, Kostman JR, Tebas P, Landay A, Montaner LJ, Jacobson JM, Li JZ, Abdel-Mohsen M. Nat Commun. 2021 Jun 29;12(1):3922.
READ MORE
Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients.
Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Front Immunol. 2021 Jun 9;12:686240.
Persistence of HIV After Allogeneic Bone Marrow Transplant in a Dually Infected Individual.
Capoferri AA, Redd AD, Gocke CD, Clark LR, Ambinder RF, Durand CM. AIDS Res Hum Retroviruses. 2021 Jul 5. doi: 10.1089/AID.2021.0047.
Antibodies from rabbits immunized with HIV-1 clade B SOSIP trimers can neutralize multiple clade B viruses by destabilizing the envelope glycoprotein.
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, de la Peña AT, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ. J Virol. 2021 Jun 2:JVI0009421. doi: 10.1128/JVI.00094-21.
May 2021
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF. Cell. 2021 May 27;184(11):2955-2972.
Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset.
Anand SP, Prévost J, Nayrac M, Beaudoin-Bussières G, Benlarbi M, Gasser R, Brassard N, Laumaea A, Gong SY, Bourassa C, Brunet-Ratnasingham E, Medjahed H, Gendron-Lepage G, Goyette G, Gokool L, Morrisseau C, Bégin P, Martel-Laferrière V, Tremblay C, Richard J, Bazin R, Duerr R, Kaufmann DE, Finzi A. Cell Reports Medicine doi: 10.1101/2021.01.25.428097.
Cellular activation, differentiation and proliferation influence the dynamics of genetically-intact proviruses over time.
Horsburgh BA, Hiener B, Fisher K, Lee E, Morgan H, Eden JS, von Stockenstrom S, Odevall L, Milush JM, Hoh R, Fromentin R, Chomont N, Hecht FM, Schlub TE, Deeks SG, Palmer S. J Infect Dis. 2021 May 26:jiab291. doi: 10.1093/infdis/jiab291.
Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir.
Rajashekar JK, Richard J, Beloor J, Prévost J, Anand SP, Beaudoin-Bussières G, Shan L, Herndler-Brandstetter D, Gendron-Lepage G, Medjahed H, Bourassa C, Gaudette F, Ullah I, Symmes K, Peric A, Lindemuth E, Bibollet-Ruche F, Park J, Chen HC, Kaufmann DE, Hahn BH, Sodroski J, Pazgier M, Flavell RA, Smith AB 3rd, Finzi A, Kumar P. Cell Host Microbe. 2021 May 18:S1931-3128(21)00190-6.
READ MORE
April 2021
Ethical and practical considerations for mitigating risks to sexual partners during analytical treatment interruptions in HIV cure-related research.
Dubé K, Kanazawa J, Dee L, Taylor J, Campbell DM, Brown B, Johnson MO, Saberi P, Sauceda JA, Sugarman J, Peluso MJ. HIV Res Clin Pract. 2021 Feb;22(1):14-30.
Optimization of AAV vectors to target persistent viral reservoirs.
Colón-Thillet R, Jerome KR, Stone D. Virol J. 2021 Apr 23;18(1):85.
Robust CAR-T memory formation and function via hematopoietic stem cell delivery.
Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PLoS Pathog. 2021 Apr 1;17(4):e1009404.
READ MORE
Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4(+) T cell subsets in vivo.
Xie G, Luo X, Ma T, Frouard J, Neidleman J, Hoh R, Deeks SG, Greene WC, Roan NR. Cell Rep. 2021 Apr 27;35(4):109038.
Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4(+) T cell subsets in vivo.
Xie G, Luo X, Ma T, Frouard J, Neidleman J, Hoh R, Deeks SG, Greene WC, Roan NR. Cell Rep. 2021 Apr 27;35(4):109038.
Shock-and-kill versus block-and-lock: Targeting the fluctuating and heterogeneous HIV-1 gene expression.
Yeh YJ, Ho YC. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2103692118
March 2021
A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2.
Pedro KD, Agosto LM, Sewell JA, Eberenz KA, He X, Fuxman Bass JI, Henderson AJ. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2012835118. doi: 10.1073/pnas.2012835118.
Impact of anti-PD-1 and anti-CTLA-4 on the HIV reservoir in people living with HIV with cancer on antiretroviral therapy: The AIDS Malignancy Consortium-095 study.
Rasmussen TA, Rajdev L, Rhodes A, Dantanarayana A, Tennakoon S, Chea S, Spelman T, Lensing S, Rutishauser R, Bakkour S, Busch M, Siliciano JD, Siliciano RF, Einstein MH, Dittmer DP, Chiao E, Deeks S, Durand C, Lewin SR. Clin Infect Dis. 2021 Mar 2:ciaa1530. doi: 10.1093/cid/ciaa1530.
READ MORE
February 2021
Participant Perspectives and Experiences Entering an Intensively Monitored Antiretroviral Pause (IMAP): Results from the AIDS Clinical Trials Group (ACTG) A5345 Biomarker Study.
Diepstra KL, Barr L, Palm D, Hogg E, Mollan K, Henley L, Stover A, Simoni J, Sugarman J, Brown B, Sauceda JA, Deeks SG, Fox L, Gandhi R, Smith DM, Li J, Dube K. AIDS Res Hum Retroviruses. 2021 Jan 20. doi: 10.1089/AID.2020.0222.
READ MORE
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M, Kerrison N, Zhao K, Brunet-Ratnasingham E, Henry D, Kimchi N, Afrasiabi Z, Rezk N, Bouab M, Petitjean L, Guzman C, Xue X, Tselios C, Vulesevic B, Adeleye O, Abdullah T, Almamlouk N, Chen Y, Chassé M, Durand M, Paterson C, Normark J, Frithiof R, Lipcsey M, Hultström M, Greenwood CMT, Zeberg H, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE, Richards JB. Nat Med. 2021 Apr;27(4):659-667.
Single-Molecule FRET Imaging of Virus Spike-Host Interactions.
Lu M. Viruses. 2021 Feb 21;13(2):332.
January 2021
"I would really want to know that they had my back": Transgender women's perceptions of HIV cure-related research in the United States.
Poteat T, Aqil A, Corbett D, Evans D, Dubé K. PLoS One. 2020 Dec 31;15(12):e0244490.
The single-cell landscape of immunological responses of CD4+ T cells in HIV versus severe acute respiratory syndrome coronavirus 2.
Collora JA, Liu R, Albrecht K, Ho YC. Curr Opin HIV AIDS. 2021 Jan;16(1):36-47.
Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques.
Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen IS, Zack JA, Kitchen SG, Kiem HP, Peterson CW. JCI Insight. 2021 Jan 11;6(1):e141502. doi: 10.1172/jci.insight.141502.
READ MORE
No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells.
McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA. BMC Biol. 2021 Jan 20;19(1):10.
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART.
Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW. PLoS Pathog. 2021 Jan 19;17(1):e1009214.
December 2020
Adeno-associated virus (AAV) capsid engineering in liver-directed gene therapy.
Rodríguez-Márquez E, Meumann N, Büning H. Expert Opin Biol Ther. 2020 Dec 30:1-18. doi: 10.1080/14712598.2021.1865303.
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
Rachel L Rutishauser, Christian Deo T Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L Roth, Lynn Wang, Kyle A Raymond, Carly E Starke, Joseph C Mudd, Wenxuan Chen, Carolyn P Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa R Krone, Frederick M Hecht, Christopher D Pilcher, Jeffrey N Martin, Richard A Koup, Daniel C Douek, Jason M Brenchley, Rafick-Pierre Sékaly, Satish K Pillai, Alexander Marson, Steven G Deeks, Joseph M McCune, Peter W Hunt
2020 Dec 22;136648. doi: 10.1172/jci.insight.136648.
Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity.
Jacquet S, Pontier D, Etienne L. Front Immunol. 2020 Dec 18;11:605270. doi: 10.3389/fimmu.2020.605270. eCollection 2020.
Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals.
Beaudoin-Bussières G, Laumaea A, Anand SP, Prévost J, Gasser R, Goyette G, Medjahed H, Perreault J, Tremblay T, Lewin A, Gokool L, Morrisseau C, Bégin P, Tremblay C, Martel-Laferrière V, Kaufmann DE, Richard J, Bazin R, Finzi A. mBio. 2020 Oct 16;11(5):e02590-20.
Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.
Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA. PLoS Pathog. 2020 Nov 30;16(11):e1009060. doi: 10.1371/journal.ppat.1009060. eCollection 2020 Nov.
November 2020
Comprehensive mapping of the human cytokine gene regulatory network.
Santoso CS, Li Z, Lal S, Yuan S, Gan KA, Agosto LM, Liu X, Pro SC, Sewell JA, Henderson A, Atianand MK, Fuxman Bass JI. Nucleic Acids Res. 2020 Nov 12:gkaa1055. doi: 10.1093/nar/gkaa1055.
Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies.
Lau JSY, Smith MZ, Allan B, Martinez C, Power J, Lewin SR, McMahon JH. AIDS Res Ther. 2020 Nov 10;17(1):65.
READ MORE
A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Ozorowski G, Torres JL, Santos-Martins D, Forli S, Ward AB. Cell Rep. 2020 Nov 24;33(8):108428
Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice.
van der Velden YU, Villaudy J, Siteur-van Rijnstra E, van der Linden CA, Vink MA, Schermer EE, Weijer K, Berkhout B, Sanders RW, van Gils MJ. MAbs. 2020 Jan-Dec;12(1):1845908.
October 2020
Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms.
Bowman ER, Cameron CM, Richardson B, Kulkarni M, Gabriel J, Cichon MJ, Riedl KM, Mustafa Y, Cartwright M, Snyder B, Raman SV, Zidar DA, Koletar SL, Playford MP, Mehta NN, Sieg SF, Freeman ML, Lederman MM, Cameron MJ, Funderburg NT. PLoS Pathog. 2020 Oct 1;16(10):e1008869
Mining for humoral correlates of HIV control and latent reservoir size.
Das J, Devadhasan A, Linde C, Broge T, Sassic J, Mangano M, O'Keefe S, Suscovich T, Streeck H, Irrinki A, Pohlmeyer C, Min-Oo G, Lin S, Weiner JA, Cihlar T, Ackerman ME, Julg B, Deeks S, Lauffenburger DA, Alter G. PLoS Pathog. 2020 Oct 13;16(10):e1008868.
READ MORE
Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. J Virol. 2020 Oct 28:JVI.01331-20. doi: 10.1128/JVI.01331-20.
Association of Viral Persistence and Atherosclerosis in Adults With Treated HIV Infection.
McLaughlin MM, Ma Y, Scherzer R, Rahalkar S, Martin JN, Mills C, Milush J, Deeks SG, Hsue PY. JAMA Netw Open. 2020 Oct 1;3(10):e2018099. doi: 10.1001/jamanetworkopen.2020.18099.
Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9.
Olson A, Basukala B, Lee S, Gagne M, Wong WW, Henderson AJ. Viruses. 2020 Oct 12;12(10):1154. doi: 10.3390/v12101154.
Leveraging the advances in HIV for COVID-19.
McMahon JH, Hoy JF, Kamarulzaman A, Bekker LG, Beyrer C, Lewin SR. Lancet. 2020 Oct 3;396(10256):943-944. doi: 10.1016/S0140-6736(20)32012-2.
September 2020
Recommendations for measuring HIV reservoir size in cure-directed clinical trials.
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR, Spivak AM, Planelles V, Hahn BH, Smith DM, Ho YC, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I, Riley JL, Tebas P, Montaner LJ; BEAT-HIV Delaney Collaboratory to Cure HIV-1 infection. Nat Med. 2020 Sep;26(9):1339-1350.
A targeted reactivation of latent HIV-1 using an activator vector in patient samples from acute infection.
Mann JFS, Pankrac J, Klein K, McKay PF, King DFL, Gibson R, Wijewardhana CN, Pawa R, Meyerowitz J, Gao Y, Canaday DH, Avino M, Poon AFY, Foster C, Fidler S, Shattock RJ, Arts EJ.
EBioMedicine. 2020 Sep;59:102853. doi: 10.1016/j.ebiom.2020.102853.
Allogeneic bone marrow transplantation with post-transplant cyclophosphamide for patients with HIV and haematological malignancies: a feasibility study.
Durand CM, Capoferri AA, Redd AD, Zahurak M, Rosenbloom DIS, Cash A, Avery RK, Bolaños-Meade J, Bollard CM, Bullen CK, Flexner C, Fuchs EJ, Gallant J, Gladstone DE, Gocke CD, Jones RJ, Kasamon YL, Lai J, Levis M, Luznik L, Marr KA, McHugh HL, Mehta Steinke S, Pham P, Pohlmeyer C, Pratz K, Shoham S, Wagner-Johnston N, Xu D, Siliciano JD, Quinn TC, Siliciano RF, Ambinder RF.
Lancet HIV. 2020 Sep;7(9):e602-e610.
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.
Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. Elife. 2020 Sep 29;9:e60933. doi: 10.7554/eLife.60933.
READ MORE
Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.
Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA. AIDS. 2020 Sep 8. doi: 10.1097/QAD.0000000000002684.
READ MORE
DGINN, an automated and highly-flexible pipeline for the detection of genetic innovations on protein-coding genes.
Picard L, Ganivet Q, Allatif O, Cimarelli A, Guéguen L, Etienne L. Nucleic Acids Res. 2020 Sep 17:gkaa680. doi: 10.1093/nar/gkaa680.
Gene transfer in AAV seropositive rhesus macaques following rapamycin treatment and subcutaneous delivery of AAV6 but not retargeted AAV6 vectors.
Stone D, Kenkel EJ, Loprieno MA, Tanaka M, De Silva Feelixge HS, Kumar AK, Stensland L, Obenza WM, Wangari S, Ahrens CY, Murnane RD, Peterson C, Kiem HP, Huang ML, Aubert M, Hu SL, Jerome KR. Hum Gene Ther. 2020 Sep 30. doi: 10.1089/hum.2020.113.
Resistance Profile of Human Immunodeficiency Virus 1 (HIV-1) Quasispecies in Patients Under Treatment Failure Using Single Molecule, Real-Time (SMRT) Sequencing.
Monaco DC, Zapata L, Hunter E, Salomon H, Dilernia DA. AIDS. 2020 Sep 25. doi: 10.1097/QAD.0000000000002697.
Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers.
Schorcht A, van den Kerkhof TLGM, Cottrell CA, Allen JD, Torres JL, Behrens AJ, Schermer EE, Burger JA, de Taeye SW, de la Peña AT, Bontjer I, Gumbs S, Ozorowski G, LaBranche CC, de Val N, Yasmeen A, Klasse PJ, Montefiori DC, Moore JP, Schuitemaker H, Crispin M, van Gils MJ, Ward AB, Sanders RW. J Virol. 2020 Sep 30:JVI.01214-20. doi: 10.1128/JVI.01214-20.
August 2020
Interferon-α alters host glycosylation machinery during treated HIV infection.
Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, Tebas P, O'Doherty U, Tateno H, Liu Q, Betts MR, Montaner LJ, Abdel-Mohsen M. EBioMedicine. 2020 Aug 19;59:102945. doi: 10.1016/j.ebiom.2020.102945.
Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy.
Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. Cell Rep. 2020 Aug 4;32(5):107991. doi: 10.1016/j.celrep.2020.107991.
READ MORE
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART.
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R, Chomont N. Nat Commun. 2020 Aug 14;11(1):4089.
Immunometabolism and HIV-1 pathogenesis: food for thought.
Sáez-Cirión A, Sereti I. Nat Rev Immunol. 2020 Aug 6. doi: 10.1038/s41577-020-0381-7.
Operationalizing HIV cure-related trials with analytic treatment interruptions during the SARS-CoV-2 pandemic: A collaborative approach.
Peluso MJ, Dee L, Shao S, Taylor J, Campbell D, Collins S, Gandhi M, Johnston R, Deeks SG, Sauceda JA, Dubé K. Clin Infect Dis. 2020 Aug 25:ciaa1260. doi: 10.1093/cid/ciaa1260.
Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.
Henrich TJ, Schreiner C, Cameron C, Hogan LE, Richardson B, Rutishauser RL, Deitchman AN, Chu S, Rogers R, Thanh C, Gibson EA, Zarinsefat A, Bakkour S, Aweeka F, Busch MP, Liegler T, Baker C, Milush J, Deeks SG, Stock PG. Am J Transplant. 2020 Aug 11. doi: 10.1111/ajt.16244.
Distinct viral reservoirs in individuals with spontaneous control of HIV-1.
Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XG. Nature. 2020 Aug 26. doi: 10.1038/s41586-020-2651-8.
READ MORE
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ. PLoS Pathog. 2020 Aug 31;16(8):e1008753.
Large-scale site-specific mapping of the O-GalNAc glycoproteome.
Yang W, Song A, Ao M, Xu Y, Zhang H. Nat Protoc. 2020 Aug;15(8):2589-2610. doi: 10.1038/s41596-020-0345-1.
July 2020
Hepatitis C virus modulates IgG glycosylation in HIV co-infected antiretroviral therapy suppressed individuals.
Giron LB, Azzoni L, Yin X, Lynn KM, Ross BN, Fair M, Damra M, Sciorillo AC, Liu Q, Jacobson JM, Mounzer K, Kostman JR, Abdel-Mohsen M, Montaner LJ, Papasavvas E. AIDS. 2020 Aug 1;34(10):1461-1466. 32675559
Delayed Expression of PD-1 and TIGIT on HIV-Specific CD8 T Cells in Untreated HLA-B*57:01 Individuals Followed from Early Infection.
Scharf L, Tauriainen J, Buggert M, Hartogensis W, Nolan DJ, Deeks SG, Salemi M, Hecht FM, Karlsson AC. J Virol. 2020 Jul 1;94(14):e02128-19.
Long-Term TDF-Inclusive ART and Progressive Rates of HBsAg Loss in HIV-HBV Coinfection-Lessons for Functional HBV Cure?
Audsley J, Avihingsanon A, Littlejohn M, Bowden S, Matthews GV, Fairley CK, Lewin SR, Sasadeusz J. J Acquir Immune Defic Syndr. 2020 Aug 15;84(5):527-533.
Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2.
Hopfensperger K, Richard J, Stürzel CM, Bibollet-Ruche F, Apps R, Leoz M, Plantier JC, Hahn BH, Finzi A, Kirchhoff F, Sauter D. mBio. 2020 Jul 14;11(4):e00782-20.
SERINC5 Potently Restricts Retrovirus Infection In Vivo.
Timilsina U, Umthong S, Lynch B, Stablewski A, Stavrou S. mBio. 2020 Jul 14;11(4):e00588-20.
READ MORE
Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages.
Meshesha M, Esadze A, Cui J, Churgulia N, Sahu SK, Stivers JT. PLoS One. 2020 Jul 14;15(7):e0235012.
June 2020
Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy.
Papasavvas E, Azzoni L, Ross BN, Fair M, Yuan Z, Gyampoh K, Mackiewicz A, Sciorillo AC, Paggliuzza A, Lada SM, Wu G, Goh SL, Bahnck-Teets C, Holder DJ, Zuck PD, Damra M, Lynn KM, Tebas P, Mounzer K, Kostman JR, Abdel-Mohsen M, Richman D, Chomont N, Howell BJ, Montaner LJ.
Clin Infect Dis. 2020 Jun 18:ciaa809. doi: 10.1093/cid/ciaa809.
FOXO1 Promotes HIV Latency by Suppressing ER Stress in T Cells.
Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA , Walter M, Habrylo I, Cruz A, Deeks S , Pillai S, Verdin E, Ott M.
Nat Microbiol 2020; doi: 10.1038/s41564-020-0742-9.
Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity.
Harris M, Ratnapriya S, Chov A, Cervera H, Block A, Gu C, Talledge N, Mansky LM, Sodroski J, Herschhorn A.
Cell Rep. 2020 Jun 9;31(10):107749.
Altered immune reconstitution in HIV positive allogeneic stem cell transplant recipients.
Murray DD, Zaunders J, Milliken ST, Munier CML, Ford C, Morrissey CO, Visweswaran M, Avery S, Sasadeusz J, Kwan J, Desai S, Law M, Koelsch KK, Lewin SR, Moore J, Kelleher AD, Polizzotto MN.
Clin Infect Dis. 2020 Jun 10:ciaa748. doi: 10.1093/cid/ciaa748.
READ MORE
HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite.
Nogal B, McCoy LE, van Gils MJ, Cottrell CA, Voss JE, Andrabi R, Pauthner M, Liang CH, Messmer T, Nedellec R, Shin M, Turner HL, Ozorowski G, Sanders RW, Burton DR, Ward AB. Sci Adv. 2020 Jun 5;6(23):eaba0512.
May 2020
'Rinse and Replace': Boosting T Cell Turnover To Reduce HIV-1 Reservoirs
Grossman Z, Singh NJ, Simonetti FR, Lederman MM, Douek DC, Deeks SG; Contributing authors.
Trends Immunol 2020 Jun;41(6):466-480.
Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1.
Eberhard JM, Angin M, Passaes C, Salgado M, Monceaux V, Knops E, Kobbe G, Jensen B, Christopeit M, Kröger N, Vandekerckhove L, Badiola J, Bandera A, Raj K, van Lunzen J, Hütter G, Kuball JHE, Martinez-Laperche C, Balsalobre P, Kwon M, Díez-Martín JL, Nijhuis M, Wensing A, Martinez-Picado J, Schulze Zur Wiesch J, Sáez-Cirión A.
Sci Transl Med. 2020 May 6;12(542):eaay9355.
READ MORE
Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions.
Seabright GE, Cottrell CA, van Gils MJ, D'addabbo A, Harvey DJ, Behrens AJ, Allen JD, Watanabe Y, Scaringi N, Polveroni TM, Maker A, Vasiljevic S, de Val N, Sanders RW, Ward AB, Crispin M.
Structure. 2020 May 12:S0969-2126(20)30168-4.
A flexible nonlinear mixed effects model for HIV viral load rebound after treatment interruption.
Wang R, Bing A, Wang C, Hu Y, Bosch RJ, DeGruttola V.
Stat Med. 2020 Jul 10;39(15):2051-2066.
April 2020
Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.
Stephenson KE, Wagh K, Korber B, Barouch DH.
Annu Rev Immunol. 2020 Apr 26;38:673-703.
The immune response fails to control HIV early in initial virus spread.
Cohn LB, Deeks SG.
J Clin Invest. 2020 Apr 27. pii: 136886. doi: 10.1172/JCI136886.
READ MORE
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
Cohn LB, Chomont N, Deeks SG.
Cell Host Microbe. 2020 Apr 8;27(4):519-530.
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy.
Niessl J, Baxter AE, Morou A, Brunet-Ratnasingham E, Sannier G, Gendron-Lepage G, Richard J, Delgado GG, Brassard N, Turcotte I, Fromentin R, Bernard NF, Chomont N, Routy JP, Dubé M, Finzi A, Kaufmann DE.
EBioMedicine. 2020 Apr 5;54:102727.
March 2020
Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection.
Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang H, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M.
Mucosal Immunol. 2020 Mar 9. doi: 10.1038/s41385-020-0279-5.
Assessing suitability of next-generation viral outgrowth assays as proxies for classic QVOA to measure HIV-1 latent reservoir size.
Stone M, Rosenbloom D, Bacchetti P, Deng X, Dimapasoc M, Keating S, Bakkour S, Richman D, Mellors J, Deeks S, Lai J, Beg S, Siliciano J, Pagliuzza A, Chomont N, Lackman-Smith C, Ptak RG, Busch MP; Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group.
J Infect Dis. 2020 Mar 9. pii: jiaa089. doi: 10.1093/infdis/jiaa089. [Epub ahead of print]
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection.
Leyre L, Kroon E, Vandergeeten C, Sacdalan C, Colby DJ, Buranapraditkun S, Schuetz A, Chomchey N, de Souza M, Bakeman W, Fromentin R, Pinyakorn S, Akapirat S, Trichavaroj R, Chottanapund S, Manasnayakorn S, Rerknimitr R, Wattanaboonyoungcharoen P, Kim JH, Tovanabutra S, Schacker TW, O'Connell R, Valcour VG, Phanuphak P, Robb ML, Michael N, Trautmann L, Phanuphak N, Ananworanich J, Chomont N; RV254/SEARCH010, RV304/SEARCH013, SEARCH011 study groups.
Sci Transl Med. 2020 Mar 4;12(533). pii: eaav3491. doi: 10.1126/scitranslmed.aav3491.
Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.
Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM.
J Acquir Immune Defic Syndr. 2020 Apr 15;83(5):530-537. doi: 10.1097/QAI.0000000000002287.
READ MORE
Participant Perspectives in an HIV Cure-Related Trial Conducted Exclusively in Women in the United States: Results from AIDS Clinical Trials Group (ACTG) 5366.
Dube K, Hosey L, Starr K, Barr L, Evans D, Hoffman E, Campbell D, Simoni J, Sugarman J, Sauceda J, Brown B, Diepstra KL, Godfrey C, Kuritzkes DR, Wohl DA, Gandhi R, Scully E.
AIDS Res Hum Retroviruses. 2020 Mar 11. doi: 10.1089/AID.2019.0284.
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report.
Gupta RK, Peppa D, Hill AL, Gálvez C, Salgado M, Pace M, McCoy LE, Griffith SA, Thornhill J, Alrubayyi A, Huyveneers LEP, Nastouli E, Grant P, Edwards SG, Innes AJ, Frater J, Nijhuis M, Wensing AMJ, Martinez-Picado J, Olavarria E.
Lancet HIV. 2020 Mar 9. pii: S2352-3018(20)30069-2. doi: 10.1016/S2352-3018(20)30069-2.
A cure for HIV: how would we know?
Zerbato JM, Lewin SR.
Lancet HIV. 2020 Mar 9. pii: S2352-3018(20)30075-8. doi: 10.1016/S2352-3018(20)30075-8.
Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.
Selyutina A, Persaud M, Simons LM, Bulnes-Ramos A, Buffone C, Martinez-Lopez A, Scoca V, Di Nunzio F, Hiatt J, Marson A, Krogan NJ, Hultquist JF, Diaz-Griffero F.
Cell Rep. 2020 Mar 17;30(11):3766-3777.
February 2020
A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption.
Michael J Peluso, Lynda Dee , Danielle Campbell , Jeff Taylor , Rebecca Hoh, Rachel L Rutishauser, John Sauceda, Steven G Deeks , Karine Dubé
JVE. 2020. 6:34-37
Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy.
Peluso MJ, Bacchetti P, Ritter KD, Beg SA, Lai J, Martin JN, Hunt PW, Henrich TJ, Siliciano JD, Siliciano RF, Laird GM, Deeks SG.
JCI Insight. 2020 Feb 11. pii: 132997. doi: 10.1172/jci.insight.132997.
READ MORE
Reduce and Control: A Combinatorial Strategy for Achieving Sustained HIV Remissions in the Absence of Antiretroviral Therapy.
Schwarzer R, Gramatica A, Greene WC.
Viruses. 2020 Feb 8;12(2). pii: E188. doi: 10.3390/v12020188.
A systems approach to infectious disease.
Eckhardt M, Hultquist JF, Kaake RM, Hüttenhain R, Krogan NJ.
Nat Rev Genet. 2020 Feb 14. doi: 10.1038/s41576-020-0212-5.
Kick and kill for HIV latency.
Lewin SR, Rasmussen TA.
Lancet. 2020 Feb 18. pii: S0140-6736(20)30264-6. doi: 10.1016/S0140-6736(20)30264-6.
January 2020
Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint.
Giron LB, Papasavvas E, Azzoni L, Yin X, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M.
AIDS. 2020 Jan 17. doi: 10.1097/QAD.0000000000002476.
READ MORE
High levels of genetically-intact HIV in HLA-DR+ memory T-cells indicates their value for reservoir studies.
Horsburgh BA, Lee E, Hiener B, Eden JS, Schlub TE, von Stockenstrom S, Odevall L, Milush JM, Liegler T, Sinclair E, Hoh R, Boritz EA, Douek DC, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S.
AIDS. 2020 Jan 6. doi: 10.1097/QAD.0000000000002465.
Combination Immune Checkpoint Blockade to Reverse HIV Latency.
Van der Sluis RM, Kumar NA, Pascoe RD, Zerbato JM, Evans VA, Dantanarayana AI, Anderson JL, Sékaly RP, Fromentin R, Chomont N, Cameron PU, Lewin SR.
J Immunol. 2020 Jan 27. pii: ji1901191. doi: 10.4049/jimmunol.1901191.
READ MORE
HIV-1 Vpu downregulates Tim-3 from the surface of infected CD4+ T cells.
Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD.
J Virol. 2020 Jan 15. pii: JVI.01999-19. doi: 10.1128/JVI.01999-19.
Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits.
Yang YR, McCoy LE, van Gils MJ, Andrabi R, Turner HL, Yuan M, Cottrell CA, Ozorowski G, Voss J, Pauthner M, Polveroni TM, Messmer T, Wilson IA, Sanders RW, Burton DR, Ward AB.
J Virol. 2020 Jan 15. pii: JVI.01861-19. doi: 10.1128/JVI.01861-19.
December 2019
Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques.
Manuzak JA, Zevin AS, Cheu R, Richardson B, Modesitt J, Hensley-McBain T, Miller C, Gustin AT, Coronado E, Gott T, Fang M, Cartwright M, Wangari S, Agricola B, May D, Smith E, Hampel HB, Gale M, Cameron CM, Cameron MJ, Smedley J, Klatt NR.
Mucosal Immunol. 2019 Dec 4. doi: 10.1038/s41385-019-0238-1.
Why and where an HIV cure is needed and how it might be achieved.
Ndung'u T, McCune JM, Deeks SG.
Nature. 2019 Dec;576(7787):397-405.
Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells.
Nguyen S, Deleage C, Darko S, Ransier A, Truong DP, Agarwal D, Japp AS, Wu VH, Kuri-Cervantes L, Abdel-Mohsen M, Del Rio Estrada PM, Ablanedo-Terrazas Y, Gostick E, Hoxie JA, Zhang NR, Naji A, Reyes-Terán G, Estes JD, Price DA, Douek DC, Deeks SG, Buggert M, Betts MR.
Sci Transl Med. 2019 Dec 18;11(523).
READ MORE
Quantification of viral RNA and DNA positive cells in tissues from simiam immunodeficiency virus/simian human immunodeficiency virus infected controller and progressor rhesus macaques.
Pahar B, Kuebler D, Rasmussen T, Wang X, Srivastav SK, Das A, Veazey RS.
Front Micro 2019 Dec 20. doi: 10.3389/fmicb.2019.02933.
November 2019
The impact of antiretroviral therapy duration on the HIV-1 infection of T-cells within anatomic sites.
Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S.
J Virol. 2019 Nov 13. pii: JVI.01270-19. doi: 10.1128/JVI.01270-19.
Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy.
Pardons M, Fromentin R, Pagliuzza A, Routy JP, Chomont N.
Cell Rep. 2019 Nov 26;29(9):2783-2795.
Circulating CD30+ CD4+ T Cells Increase Prior to HIV Rebound Following Analytical Antiretroviral Treatment Interruption.
Prator CA, Thanh C, Kumar S, Pan T, Peluso MJ, Bosch R, Jones N, Milush JM, Bakkour S, Stone M, Busch MP, Deeks SG, Hunt PW, Henrich TJ.
J Infect Dis. 2019 Nov 2. pii: jiz572. doi: 10.1093/infdis/jiz572.
READ MORE
October 2019
Infrequent HIV infection of circulating monocytes during antiretroviral therapy.
Massanella M, Bakeman W, Sithinamsuwan P, Fletcher JLK, Chomchey N, Tipsuk S, Chalermchai T, Routy JP, Ananworanich J, Valcour VG, Chomont N; SEARCH 011 Study Group.
J Virol. 2019 Oct 9. pii: JVI.01174-19.
Pharmacological modulation of the Wnt/β-catenin pathway inhibits proliferation and promotes differentiation of long-lived memory CD4+ T-cells in ART-suppressed SIV-infected macaques.
Mavigner M, Zanoni M, Tharp GK, Habib J, Mattingly CR, Lichterfeld M, Nega MT, Vanderford TH, Bosinger SE, Chahroudi A.
J Virol. 2019 Oct 16. pii: JVI.01094-19.
Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform.
Herzig E, Kim KC, Packard TA, Vardi N, Schwarzer R, Gramatica A, Deeks SG, Williams SR, Landgraf K, Killeen N, Martin DW, Weinberger LS, Greene WC.
Cell. 2019 Oct 31;179(4):880-894.
READ MORE
Community and provider Community and provider perspectives on Treatment Interruptions in the landscape of HIV cure focused studies.
Lau J, Smith MZ, Allan B, Martinez C, Power J, Lewin SR, McMahon JH.
AIDS Res Hum Retroviruses. 2019 Oct 14. doi: 10.1089/AID.2019.0118.
September 2019
Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection.
Deguit CDT, Hough M, Hoh R, Krone M, Pilcher CD, Martin JN, Deeks SG, McCune JM, Hunt PW, Rutishauser RL.
J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):211-219.
Seeing Is Believing: Nuclear Imaging of HIV Persistence.
Henrich TJ, Hsue PY, VanBrocklin H.
Front Immunol. 2019 Sep 12;10:2077. doi: 10.3389/fimmu.2019.02077
READ MORE
A new family of small-molecule CD4-mimetic compounds contact the highly conserved aspartic acid 368 of HIV-1 gp120 and mediates ADCC.
Ding S, Grenier MC, Tolbert WD, Vézina D, Sherburn R, Richard J, Prévost J, Chapleau JP, Gendron-Lepage G, Medjahed H, Abrams C, Sodroski J, Pazgier M, Smith AB 3rd, Finzi A.
J Virol. 2019 Sep 25. pii: JVI.01325-19. doi: 10.1128/JVI.01325-19.
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.
Brouwer PJM, Antanasijevic A, Berndsen Z, Yasmeen A, Fiala B, Bijl TPL, Bontjer I, Bale JB, Sheffler W, Allen JD, Schorcht A, Burger JA, Camacho M, Ellis D, Cottrell CA, Behrens AJ, Catalano M, Del Moral-Sánchez I, Ketas TJ, LaBranche C, van Gils MJ, Sliepen K, Stewart LJ, Crispin M, Montefiori DC, Baker D, Moore JP, Klasse PJ, Ward AB, King NP, Sanders RW.
Nat Commun. 2019 Sep 19;10(1):4272.
August 2019
A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.
Ehrenberg PK, Shangguan S, Issac B, Alter G, Geretz A, Izumi T, Bryant C, Eller MA, Wegmann F, Apps R, Creegan M, Bolton DL, Sekaly RP, Robb ML, Gramzinski RA, Pau MG, Schuitemaker H, Barouch DH, Michael NL, Thomas R.
Sci Transl Med. 2019 Aug 28;11(507).
Strain-dependent Activation and Inhibition of Human Immunodeficiency Virus (HIV-1) Entry by a Specific PF-68742 Stereoisomer.
Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB 3rd, Madani N, Sodroski J.
J Virol. 2019 Aug 7. pii: JVI.01197-19. doi: 10.1128/JVI.01197-19.
READ MORE
July 2019
Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.
Sharma A, McLaughlin RN Jr, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, Overbaugh J.
PLoS Pathog. 2019 Jul 1;15(7):e1007925.
READ MORE
June 2019
Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses.
Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J.
MBio. 2019 Jun 18;10(3). pii: e01113-19.
READ MORE
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ.
Cell Host Microbe. 2019 Jun 24. pii: S1931-3128(19)30253-7.
READ MORE
Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Yuan M, Cottrell CA, Ozorowski G, van Gils MJ, Kumar S, Wu NC, Sarkar A, Torres JL, de Val N, Copps J, Moore JP, Sanders RW, Ward AB, Wilson IA.
Cell Host Microbe. 2019 Jun 12;25(6):873-883.
READ MORE
May 2019
CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.
Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ.
Pathog Immun. 2019 May 3;4(1):147-160.
READ MORE
A gathering storm: HIV infection and nonalcoholic fatty liver disease in low and middle-income countries.
Kapoor N, Audsley J, Rupali P, Sasadeusz J, Paul TV, Thomas N, Lewin SR.
AIDS. 2019 Jun 1;33(7):1105-1115.
READ MORE
April 2019
Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members.
Gonzalo-Gil E, Rapuano PB, Ikediobi U, Leibowitz R, Mehta S, Coskun AK, Porterfield JZ, Lampkin TD, Marconi VC, Rimland D, Walker BD, Deeks S, Sutton RE.
Elife. 2019 Apr 9;8. pii: e44360.
READ MORE
An asymmetric opening of HIV-1 envelope mediates antibody-dependent cellular cytotoxicity.
Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB.
Cell Host Microbe. 2019 Apr 10;25(4):578-587.e5
Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size.
Rosenbloom DIS, Bacchetti P, Stone M, Deng X, Bosch RJ, Richman DD, Siliciano JD, Mellors JW, Deeks SG, Ptak RG, Hoh R, Keating SM, Dimapasoc M, Massanella M, Lai J, Sobolewski MD, Kulpa DA, Busch MP; Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group.
PLoS Comput Biol. 2019 Apr 12;15(4):e1006849.
March 2019
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.
Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD.
Lancet HIV. 2019 Mar 15. pii: S2352-3018(19)30052-9.
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation.
Gupta RK, Abdul-Jawad S, McCoy LE, Mok HP, Peppa D, Salgado M, Martinez-Picado J, Nijhuis M, Wensing AMJ, Lee H, Grant P, Nastouli E, Lambert J, Pace M, Salasc F, Monit C, Innes AJ, Muir L, Waters L, Frater J, Lever AML, Edwards SG, Gabriel IH, Olavarria E.
Nature. 2019 Mar 5. doi: 10.1038/s41586-019-1027-4.
Hybrid nanocarriers incorporating mechanistically distinct drugs for lymphatic CD4(+) T cell activation and HIV-1 latency reversal.
Cao S, Slack SD, Levy CN, Hughes SM, Jiang Y, Yogodzinski C, Roychoudhury P, Jerome KR, Schiffer JT, Hladik F, Woodrow KA. Sci Adv. 2019 Mar 27;5(3):eaav6322.
Clinical trials of antiretroviral treatment interruption in HIV-infected individuals.
Lau JSY, Smith MZ, Lewin SR, McMahon JH.
AIDS. 2019 Apr 1;33(5):773-791.
Modulation of the CCR5 receptor/ligand axis by seminal plasma and the utility of in vitro versus in vivo models.
Juno JA, Wragg KM, Kristensen AB, Lee WS, Selva KJ, van der Sluis RM, Kelleher AD, Bavinton BR, Grulich AE, Lewin SR, Kent SJ, Parsons MS.
J Virol. 2019 Mar 13. pii: JVI.00242-19. doi: 10.1128/JVI.00242-19.
READ MORE
Antibody-induced internalization of HIV-1 Env proteins limits the surface expression of the closed conformation of Env.
Anand SP, Grover JR, Tolbert WD, Prévost J, Richard J, Ding S, Baril S, Medjahed H, Evans DT, Pazgier M, Mothes W, Finzi A.
J Virol. 2019 Mar 20. pii: JVI.00293-19. doi: 10.1128/JVI.00293-19.
CD4- and time-dependent susceptibility of HIV-1-infected cells to ADCC.
Lee WS, Prévost J, Richard J, van der Sluis RM, Lewin SR, Pazgier M, Finzi A, Parsons MS, Kent SJ.
J Virol. 2019 Mar 6. pii: JVI.01901-18. doi: 10.1128/JVI.01901-18.
Deoxyuridine in DNA has an inhibitory and promutagenic effect on RNA transcription by diverse RNA polymerases.
Cui J, Gizzi A, Stivers JT.
Nucleic Acids Res. 2019 Mar 20. pii: gkz183. doi: 10.1093/nar/gkz183.
Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.
Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA.
AIDS. 2019 Mar 1;33(3):425-431. doi: 10.1097/QAD.0000000000002083.
February 2019
Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis.
Colomb F, Giron LB, Trbojevic-Akmacic I, Lauc G, Abdel-Mohsen M.
Curr HIV/AIDS Rep. 2019 Feb 1. doi: 10.1007/s11904-019-00433-w.
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N.
PLoS Pathog. 2019 Feb 27;15(2):e1007619.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ, Lewin SR, Routy JP, Sékaly RP, Chomont N.
Nat Commun. 2019 Feb 18;10(1):814.
READ MORE
Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.
Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM.
Clin Pharmacol Ther. 2019 Mar;105(3):692-702.
Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous retrovirus (PERV) in non-dividing cells.
Al-Shehabi H, Fiebig U, Kutzner J, Denner J, Schaller T, Bannert N, Hofmann H.
J Gen Virol. 2019 Feb 15. doi: 10.1099/jgv.0.001232.
Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells.
Verheyen J, Thielen A, Lübke N, Dirks M, Widera M, Dittmer U, Kordelas L, Däumer M, de Jong DCM, Wensing AMJ, Kaiser R, Nijhuis M, Esser S.
Clin Infect Dis. 2019 Feb 1;68(4):684-687.
Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors.
Van Hecke C, Trypsteen W, Malatinkova E, De Spiegelaere W, Vervisch K, Rutsaert S, Kinloch-de Loes S, Sips M, Vandekerckhove L.
EBioMedicine. 2019 Feb 12. pii: S2352-3964(19)30078-7.
Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.
Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA.
AIDS. 2019 Mar 1;33(3):425-431.
January 2019
Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.
Li Z, Wu J, Chavez L, Hoh R, Deeks SG, Pillai SK, Zhou Q.
PLoS Pathog. 2019 Jan 15;15(1):e1007498.
READ MORE
December 2018
Transient loss of detectable HIV-1 RNA following brentuximab vedotin anti-CD30 therapy for Hodgkin lymphoma.
Wang CC, Thanh C, Gibson EA, Ball-Burack M, Hogan LE, Descours B, Jones N, Carvidi AB, Munter S, Bakkour S, Busch MP, Milush JM, Deeks SG, Henrich TJ.
Blood Adv. 2018 Dec 11;2(23):3479-3482. doi: 10.1182/bloodadvances.2018024364.
HIV latency can be established in proliferating and nonproliferating resting CD4+ T cells in vitro: implications for latency reversal.
Moso MA, Anderson JL, Adikari S, Gray LR, Khoury G, Chang JJ, Jacobson JC, Ellett AM, Cheng WJ, Saleh S, Zaunders JJ, Purcell DFJ, Cameron PU, Churchill MJ, Lewin SR, Lu HK.
AIDS. 2019 Feb 1;33(2):199-209.
Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection.
Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A.
Cell Metab. 2018 Dec 19. pii: S1550-4131(18)30734-4.
READ MORE
CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions.
Hultquist JF, Hiatt J, Schumann K, McGregor MJ, Roth TL, Haas P, Doudna JA, Marson A, Krogan NJ.
Nat Protoc. 2019 Jan;14(1):1-27.
Stimulant Use and Viral Suppression in the Era of Universal Antiretroviral Therapy.
Carrico AW, Hunt PW, Neilands TB, Dilworth SE, Martin JN, Deeks SG, Riley ED.
J Acquir Immune Defic Syndr. 2019 Jan 1;80(1):89-93.
November 2018
Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.
Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA.
PLoS Pathog. 2018 Nov 15;14(11):e1007357.
READ MORE
HIV control: Is getting there the same as staying there?
Goulder P, Deeks SG.
PLoS Pathog. 2018 Nov 1;14(11):e1007222.
Two families of Env antibodies efficiently engage Fc-gamma receptors and eliminate HIV-1-infected cells.
Anand SP, Prévost J, Baril S, Richard J, Medjahed H, Chapleau JP, Tolbert WD, Kirk S, Smith AB 3rd, Wines BD, Kent SJ, Hogarth PM, Parsons MS, Pazgier M, Finzi A.
J Virol. 2018 Nov 14. pii: JVI.01823-18.
Functional cure of HIV: the scale of the challenge.
Davenport MP, Khoury DS, Cromer D, Lewin SR, Kelleher AD, Kent SJ.
Nat Rev Immunol. 2018 Nov 8. doi: 10.1038/s41577-018-0085-4.
HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth.
van Schooten J, van Gils MJ.
Retrovirology. 2018 Nov 26;15(1):74.
Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant.
Salgado M, Kwon M, Gálvez C, Badiola J, Nijhuis M, Bandera A, Balsalobre P, Miralles P, Buño I, Martinez-Laperche C, Vilaplana C, Jurado M, Clotet B, Wensing A, Martinez-Picado J, Diez-Martin JL; IciStem Consortium.
Ann Intern Med. 2018 Nov 20;169(10):674-683.
A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation.
Reeves DB, Duke ER, Wagner TA, Palmer SE, Spivak AM, Schiffer JT. Nat Commun. 2018 Nov 16;9(1):4811.
A Portrait of CXCR5+ Follicular Cytotoxic CD8+ T cells.
Yu D, Ye L.
Trends Immunol. 2018 Dec;39(12):965-979.
October 2018
Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys.
Borducchi EN, Liu J, Nkolola JP, Cadena AM, Yu WH, Fischinger S, Broge T, Abbink P, Mercado NB, Chandrashekar A, Jetton D, Peter L, McMahan K, Moseley ET, Bekerman E, Hesselgesser J, Li W, Lewis MG, Alter G, Geleziunas R, Barouch DH.
Nature. 2018 Oct 3. doi: 10.1038/s41586-018-0600-6.
READ MORE
Functional mapping of regions involved in the negative imprinting of virion particles infectivity and in target cell protection by the Interferon-Induced Transmembrane Protein 3 (IFITM3) against HIV-1.
Appourchaux R, Delpeuch M, Zhong L, Burlaud-Gaillard J, Tartour K, Savidis G, Brass A, Etienne L, Roingeard P, Cimarelli A.
J Virol. 2018 Oct 24. pii: JVI.01716-18.
Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation.
Scully EP, Gandhi M, Johnston R, Hoh R, Lockhart A, Dobrowolski C, Pagliuzza A, Milush JM, Baker CA, Girling V, Ellefson A, Gorelick R, Lifson J, Altfeld M, Alter G, Cedars M, Solomon A, Lewin SR, Karn J, Chomont N, Bacchetti P, Deeks SG.
J Infect Dis. 2018 Oct 29. doi: 10.1093/infdis/jiy617.
Analyses of Mitochondrial DNA and Immune Phenotyping Suggest Accelerated T-Cell Turnover in Treated HIV.
Massanella M, Karris MY, Pérez-Santiago J, Yek C, Vitomirov A, Mehta SR.
J Acquir Immune Defic Syndr. 2018 Nov 1;79(3):399-406.
September 2018
HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals.
Sung JA, Patel S, Clohosey ML, Roesch L, Tripic T, Kuruc JD, Archin N, Hanley PJ, Cruz CR, Goonetilleke N, Eron JJ, Rooney CM, Gay CL, Bollard CM, Margolis DM.
Mol Ther. 2018 Sep 4. pii: S1525-0016(18)30400-3. doi: 10.1016/j.ymthe.2018.08.015.
READ MORE
No recovery of replication-competent HIV-1 from human liver macrophages.
Kandathil AJ, Sugawara S, Goyal A, Durand CM, Quinn J, Sachithanandham J, Cameron AM, Bailey JR, Perelson AS, Balagopal A.
J Clin Invest. 2018 Sep 10. pii: 121678. doi: 10.1172/JCI121678.
August 2018
HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact.
Agosto LM, Herring MB, Mothes W, Henderson AJ.
Cell Rep. 2018 Aug 21;24(8):2088-2100.
Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial.
Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM.
Clin Pharmacol Ther. 2018 Aug 23. doi: 10.1002/cpt.1220.
The Control of HIV after Antiretroviral Medication Pause (CHAMP) study: post-treatment controllers identified from 14 clinical studies.
Namazi G, Fajnzylber JM, Aga E, Bosch R, Acosta EP, Sharaf R, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest D, Margolis D, Sneller MC, Little SJ, Gianella S, Smith D, Kuritzkes DR, Gulick RM, Mellors JW, Mehraj V, Gandhi RT, Mitsuyasu R, Schooley RT, Henry K, Tebas P, Deeks S, Chun TW, Collier AC, Routy JP, Hecht FM, Walker BD, Li JZ.
J Infect Dis. 2018 Aug 6. doi: 10.1093/infdis/jiy479.
READ MORE
July 2018
Maximising the global health impact of future HIV cure-related interventions through advance planning.
Brown R, Deeks SG, Eyal N.
J Virus Erad. 2018 Jul 1;4(3):182-185.
Inconsistent HIV reservoir dynamics and immune responses following anti-PD-1 therapy in cancer patients with HIV infection.
Scully EP, Rutishauser RL, Simoneau CR, Delagrèverie H, Euler Z, Thanh C, Li JZ, Hartig H, Bakkour S, Busch M, Alter G, Marty FM, Wang CC, Deeks SG, Lorch J, Henrich TJ.
Ann Oncol. 2018 Jul 18. doi: 10.1093.
Ethical issues in HIV remission trials.
Eyal N, Holtzman LG, Deeks SG.
Curr Opin HIV AIDS. 2018 Sep;13(5):422-427.
Variation in cell associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator BMAL-1.
Chang CC, Naranbhai V, Stern J, Roche M, Dantanarayana A, Ke R, Tennakoon S, Solomon A, Hoh R, Hartogensis W, Hecht FM, Sikaris K, Price DJ, Elliott JH, Deeks SG, Churchill M, Cameron PU, Hengartner N, Perelson AS, Lewin SR.
AIDS. 2018 Jul 12. doi: 10.1097/QAD.0000000000001937.
Structural Insights from HIV-Antibody Co-Evolution and Related Immunization Studies.
Zhou JO, Ton T, Morriss JW, Nguyen D, Fera D.
AIDS Res Hum Retroviruses. 2018 Jul 7. doi: 10.1089/AID.2018.0097
SOSIP changes affect human immunodeficiency virus (HIV-1) envelope glycoprotein conformation and CD4 engagement.
Alsahafi N, Anand SP, Castillo-Menendez L, Verly MM, Medjahed H, Prévost J, Herschhorn A, Richard J, Schön A, Melillo B, Freire E, Smith AB 3rd, Sodroski J, Finzi A.
J Virol. 2018 Jul 18. pii: JVI.01080-18.
The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells.
Alvarez-Carbonell D, Ye F, Ramanath N, Dobrowolski C, Karn J.
J Neuroimmune Pharmacol. 2018 Jul 10. doi: 10.1007/s11481-018-9798-1.
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
Biswajit Das, Curtis Dobrowolski, Benjamin Luttge, Saba Valadkhan, Nicolas Chomont, Rowena Johnston, Peter Bacchetti, Rebecca Hoh, Monica Gandhi, Steven G. Deeks, Eileen Scully, and Jonathan Karn
PNAS July 30, 2018. 201803468; published ahead of print July 30, 2018.
READ MORE
Myeloid Dendritic Cells Induce HIV Latency in Proliferating CD4+ T Cells.
Kumar NA, van der Sluis RM, Mota T, Pascoe R, Evans VA, Lewin SR, Cameron PU.
J Immunol. 2018 Jul 20. pii: ji1701233.
READ MORE
Barriers for a HIV cure: the latent reservoir.
Castro-Gonzalez S, Colomer-Lluch M, Serra-Moreno R.
AIDS Res Hum Retroviruses. 2018 Jul 28. doi: 10.1089/AID.2018.0118.
Protective efficacy of broadly neutralizing antibody PGDM1400 against HIV-1 challenge in humanized mice.
van der Velden Y, Villaudy J, Siteur-van Rijnstra E, van der Linden C, Franklin E, Weijer K, Schermer E, Vink M, Berkhout B, Sanders RW, Van Gils M.
AIDS Res Hum Retroviruses. 2018 Jul 13. doi: 10.1089/AID.2018.0114.
Rapid rebound of a preexisting CXCR4-tropic HIV variant after allogeneic transplantation with CCR5 delta32 homozygous stem cells.
Verheyen J, Thielen A, Lübke N, Dirks M, Widera M, Dittmer U, Kordales L, Däumer M, Jong TCM, Wensing AMJ, Kaiser R, Nijhuis M, Esser S.
Clin Infect Dis. 2018 Jul 18. doi: 10.1093/cid/ciy565.
Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome.
Tso FY, Kang G, Kwon EH, Julius P, Li Q, West JT, Wood C.
PLoS One. 2018 Jul 24;13(7):e0201325.
June 2018
CD4+ T cell subsets and pathways to HIV latency.
Agosto LM, Henderson AJ.
AIDS Res Hum Retroviruses. 2018 Jun 5. doi: 10.1089/AID.2018.0105.
A step forward for HIV vaccines.
Barouch DH.
Lancet HIV. 2018 Jun 8. pii: S2352-3018(18)30095-X.
Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.
Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.
Sci Immunol. 2018 Jun 1;3(24). pii: eaar4526.
READ MORE
HIV-2/SIV viral protein X counteracts HUSH repressor complex.
Chougui G, Munir-Matloob S, Matkovic R, Martin MM, Morel M, Lahouassa H, Leduc M, Ramirez BC, Etienne L, Margottin-Goguet F.
Nat Microbiol. 2018 Jun 11. doi: 10.1038/s41564-018-0179-6.
NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation.
Hogan LE, Körner C, Hobbs K, Simoneau CR, Thanh C, Gibson EA, Palmer CD, Pandit A, Marty FM, Kuritzkes DR, Jost S, Ritz J, Henrich TJ.
Blood Adv. 2018 Jun 26;2(12):1412-1416.
Conformation-dependent interactions between HIV-1 envelope glycoproteins and broadly neutralizing antibodies.
Flemming J, Wiesen L, Herschhorn A.
AIDS Res Hum Retroviruses. 2018 Jun 15. doi: 10.1089/AID.2018.0102.
The Mathilde Krim effect as a way to overcome the Matilda effect.
Izquierdo-Useros N.
AIDS Res Hum Retroviruses. 2018 Jun 26. doi: 10.1089/AID.2018.0082.
Barriers and strategies to achieve a cure for HIV.
Pitman MC, Lau JSY, McMahon JH, Lewin SR.
Lancet HIV. 2018 Jun;5(6):e317-e328.
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.
Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski J.
Nat Commun. 2018 Jun 18;9(1):2363.
Influence of biological sex, age and HIV status in an in vitro primary cell model of HIV latency using a CXCR4 tropic virus.
Macedo AB, Resop RS, Martins LJ, Szaniawski MA, Sorensen ES, Spivak AM, Nixon DF, Jones RB, Planelles V, Bosque A.
AIDS Res Hum Retroviruses. 2018 Jun 21. doi: 10.1089/AID.2018.0098.
DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection.
Stavrou S, Aguilera AN, Blouch K, Ross SR.
MBio. 2018 Jun 5;9(3). pii: e00923-18.
May 2018
HIV-1 replicates and persists in vaginal epithelial dendritic cells.
Pena-Cruz V, Agosto LM, Akiyama H, Olson A, Moreau Y, Larrieux JR, Henderson A, Gummuluru S, Sagar M.
J Clin Invest. 2018 May 3. pii: 98943.
Human Herpes Virus 8 in HIV-1 infected individuals receiving cancer chemotherapy and stem cell transplantation.
Hogan LE, Hanhauser E, Hobbs KS, Palmer CD, Robles Y, Jost S, LaCasce AS, Abramson J, Hamdan A, Marty FM, Kuritzkes DR, Henrich TJ.
PLoS One. 2018 May 10;13(5):e0197298.
Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ.
Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG.
J Histochem Cytochem. 2018 Jun;66(6):427-446.
Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
Mbonye U, Wang B, Gokulrangan G, Shi W, Yang S, Karn J.
J Biol Chem. 2018 May 9. pii: jbc.RA117.001347.
HIV latency reversing agents act through Tat post translational modifications.
Khoury G, Mota TM, Li S, Tumpach C, Lee MY, Jacobson J, Harty L, Anderson JL, Lewin SR, Purcell DFJ.
Retrovirology. 2018 May 11;15(1):36. doi: 10.1186/s12977-018-0421-6.
PD-1 contributes to the establishment and maintenance of HIV-1 latency.
Evans VA, Van Der Sluis RM, Solomon A, Dantanarayana A, McNeil C, Garsia R, Palmer S, Fromentin R, Chomont N, Sékaly RP, Cameron PU, Lewin SR.
AIDS. 2018 May 9. doi: 10.1097/QAD.0000000000001849.
April 2018
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM.
J Neurovirol. 2018 Apr;24(2):192-203.
READ MORE
Neutrophils mediate HIV-specific antibody-dependent phagocytosis and ADCC.
Worley MJ, Fei K, Lopez-Denman AJ, Kelleher AD, Kent SJ, Chung AW.
J Immunol Methods. 2018 Jun;457:41-52.
READ MORE
Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.
Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg JK, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb ML, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR.
PLoS Pathog. 2018 Apr 13;14(4):e1006973.
Incomplete downregulation of CD4 expression affects HIV-1 Env conformation and ADCC responses.
Prévost J, Richard J, Medjahed H, Alexander A, Jones J, Kappes JC, Ochsenbauer C, Finzi A.
J Virol. 2018 Apr 18. pii: JVI.00484-18.
Impact of HIV-1 Envelope Conformation on ADCC Responses.
Richard J, Prévost J, Alsahafi N, Ding S, Finzi A.
Trends Microbiol. 2018 Apr;26(4):253-265.
March 2018
A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.
Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM.
PLoS Pathog. 2018 Mar 5;14(3):e1006806.
READ MORE
Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir?
Burbelo PD, Price RW, Hagberg L, Hatano H, Spudich S, Deeks SG, Gisslén M.
J Infect Dis. 2018 Mar 13;217(7):1024-1032.
Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.
Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL.
J Immunol. 2018 Mar 1;200(5):1876-1888.
HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.
Fera D, Lee MS, Wiehe K, Meyerhoff RR, Piai A, Bonsignori M, Aussedat B, Walkowicz WE, Ton T, Zhou JO, Danishefsky S, Haynes BF, Harrison SC.
Nat Commun. 2018 Mar 16;9(1):1111.
Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses.
Richard J, Prévost J, Baxter AE, von Bredow B, Ding S, Medjahed H, Delgado GG, Brassard N, Stürzel CM, Kirchhoff F, Hahn BH, Parsons MS, Kaufmann DE, Evans DT, Finzi A.
MBio. 2018 Mar 20;9(2). pii: e00358-18.
Impact of HIV-1 Envelope Conformation on ADCC Responses.
Richard J, Prévost J, Alsahafi N, Ding S, Finzi A.
Trends Microbiol. 2018 Apr;26(4):253-265. doi: 10.1016/j.tim.2017.10.007. Epub 2017 Nov 20. Review.
HIV integration sites and implications for maintenance of the reservoir.
Symons J, Cameron PU, Lewin SR.
Curr Opin HIV AIDS. 2018 Mar;13(2):152-159.
Deaminase-Dead Mouse APOBEC3 is an In Vivo Retroviral Restriction Factor.
Stavrou S, Zhao W, Blouch K, Ross SR.
J Virol. 2018 Mar 28. pii: JVI.00168-18.
February 2018
Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection.
Adland E, Hill M, Lavandier N, Csala A, Edwards A, Chen F, Radkowski M, Kowalska JD, Paraskevis D, Hatzakis A, Valenzuela-Ponce H, Pfafferott K, Williams I, Pellegrino P, Borrow P, Mori M, Rockstroh J, Prado JG, Mothe B, Dalmau J, Martinez-Picado J, Tudor-Williams G, Frater J, Stryhn A, Buus S, Teran GR, Mallal S, John M, Buchbinder S, Kirk G, Martin J, Michael N, Fellay J, Deeks S, Walker B, Avila-Rios S, Cole D, Brander C, Carrington M, Goulder P.
J Virol. 2018 Jan 30;92(4).
HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors.
Bannert N, Hofmann H, Block A, Hohn O.
Front Microbiol. 2018 Feb 13;9:178.
Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals.
Prévost J, Richard J, Ding S, Pacheco B, Charlebois R, Hahn BH, Kaufmann DE, Finzi A.
Virology. 2018 Feb;515:38-45
Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.
Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ.
PLoS Pathog. 2018 Feb 22;14(2):e1006856.
READ MORE
Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.
Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, Piechocka-Trocha A, Wong H, Jeng E, Nixon DF, Ho YC, Siliciano RF, Walker BD, Jones RB.
J Clin Invest. 2018 Feb 1;128(2):876-889.
READ MORE
Immune checkpoint blockade in infectious diseases.
Wykes MN, Lewin SR.
Nat Rev Immunol. 2018 Feb;18(2):91-104.
Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses.
Brinkmann CR, Højen JF, Rasmussen TA, Kjær AS, Olesen R, Denton PW, Østergaard L, Ouyang Z, Lichterfeld M, Yu X, Søgaard OS, Dinarello C, Tolstrup M.
mSphere. 2018 Feb 14;3(1). pii: e00616-17.
January 2018
A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system.
Pankrac J, Klein K, McKay PF, King DFL, Bain K, Knapp J, Biru T, Wijewardhana CN, Pawa R, Canaday DH, Gao Y, Fidler S, Shattock RJ, Arts EJ, Mann JFS.
NPJ Vaccines. 2018 Jan 19;3:2.
Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner.
Kim JT, Chang E, Sigal A, Baltimore D.
PLoS One. 2018 Jan 2;13(1):e0189945.
READ MORE
Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA.
Ferdin J, Goričar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, Deeks SG, Lenassi M.
PLoS One. 2018 Jan 24;13(1):e0191613.
Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.
Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD.
PLoS Pathog. 2018 Jan 5;14(1):e1006830.
Getting the "Kill" into "Shock and Kill": Strategies to Eliminate Latent HIV.
Kim Y, Anderson JL, Lewin SR.
Cell Host Microbe. 2018 Jan 10;23(1):14-26.
Towards a cure for human immunodeficiency virus.
Pitman MC, Lewin SR.
Intern Med J. 2018 Jan;48(1):12-15.
Digital PCR as a tool to measure HIV persistence.
Rutsaert S, Bosman K, Trypsteen W, Nijhuis M, Vandekerckhove L.
Retrovirology. 2018 Jan 30;15(1):16.