amfAR, The Foundation for AIDS Research

Publications from amfAR Grantees and Fellows (2017-2004)

Publications from amfAR Grantees and Fellows

December 2017

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
Gavegnano C, Brehm JH, Dupuy FP, Talla A, Ribeiro SP, Kulpa DA, Cameron C, Santos S, Hurwitz SJ, Marconi VC, Routy JP, Sabbagh L, Schinazi RF, Sékaly RP.
PLoS Pathog. 2017 Dec 21;13(12):e1006740.
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Systems serology: profiling vaccine induced humoral immunity against HIV.
Chung AW, Alter G.
Retrovirology. 2017 Dec 21;14(1):57.
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A Role for Fc-Mediated Humoral Immunity in Reducing HIV Transmission Rates between HIV Serodiscordant Heterosexual Couples.
Kent SJ, Chung AW.
EBioMedicine. 2017 Dec;26:2-3.
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Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals.
Prévost J, Richard J, Ding S, Pacheco B, Charlebois R, Hahn BH, Kaufmann DE, Finzi A.
Virology. 2017 Dec 14;515:38-45.
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Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.
Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG.
PLoS Pathog. 2017 Dec 28;13(12):e1006753.
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Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation.
Admiraal R, de Koning CCH, Lindemans CA, Bierings MB, Wensing AMJ, Versluys AB, Wolfs TFW, Nierkens S, Boelens JJ.
J Allergy Clin Immunol. 2017 Dec;140(6):1643-1650.


November 2017

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes.
Burwitz BJ, Wu HL, Abdulhaqq S, Shriver-Munsch C, Swanson T, Legasse AW, Hammond KB, Junell SL, Reed JS, Bimber BN, Greene JM, Webb GM, Northrup M, Laub W, Kievit P, MacAllister R, Axthelm MK, Ducore R, Lewis A, Colgin LMA, Hobbs T, Martin LD, Ferguson B, Thomas CR Jr, Panoskaltsis-Mortari A, Meyers G, Stanton JJ, Maziarz RT, Sacha JB.
Nat Commun. 2017 Nov 10;8(1):1418.
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HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.
Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG.
PLoS Med. 2017 Nov 7;14(11):e1002417.
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Mistrust and Endorsement of Human Immunodeficiency Virus Conspiracy Theories Among Human Immunodeficiency Virus-Infected African American Veterans.
Mattocks KM, Gibert C, Fiellin D, Fiellin LE, Jamison A, Brown A, Justice AC.
Mil Med. 2017 Nov;182(11):e2073-e2079.

Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.
Boehm D, Ott M.
AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S8-S22.

An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.
Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S.
AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S31-S39.

Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure.
Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S.
AIDS Res Hum Retroviruses. 2017 Nov;33(S1):S40-S58.

October 2017

Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N, Kaufmann DE.
Nat Protoc. 2017 Oct;12(10):2029-2049.

The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.
Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.
Nat Commun. 2017 Oct 19;8(1):1049.

HIV cure research: print and online media reporting in Australia.
Power J, Fileborn B, Dowsett GW, Lucke J, Brown G, Ellard J, Lewin SR, Tucker JD, Slavin S, Sugarman J, Hill S.
J Virus Erad. 2017 Oct 1;3(4):229-235.

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.
Hiener B, Horsburgh BA, Eden JS, Barton K, Schlub TE, Lee E, von Stockenstrom S, Odevall L, Milush JM, Liegler T, Sinclair E, Hoh R, Boritz EA, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S.
Cell Rep. 2017 Oct 17;21(3):813-822

CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.
McGary CS, Deleage C, Harper J, Micci L, Ribeiro SP, Paganini S, Kuri-Cervantes L, Benne C, Ryan ES, Balderas R, Jean S, Easley K, Marconi V, Silvestri G, Estes JD, Sekaly RP, Paiardini M.
Immunity. 2017 Oct 17;47(4):776-788.

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection.
Shan L, Deng K, Gao H, Xing S, Capoferri AA, Durand CM, Rabi SA, Laird GM, Kim M, Hosmane NN, Yang HC, Zhang H, Margolick JB, Li L, Cai W, Ke R, Flavell RA, Siliciano JD, Siliciano RF.
Immunity. 2017 Oct 17;47(4):766-775.

September 2017

Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.
Julg B, Liu PT, Wagh K, Fischer WM, Abbink P, Mercado NB, Whitney JB, Nkolola JP, McMahan K, Tartaglia LJ, Borducchi EN, Khatiwada S, Kamath M, LeSuer JA, Seaman MS, Schmidt SD, Mascola JR, Burton DR, Korber BT, Barouch DH.
Sci Transl Med. 2017 Sep 20;9(408).
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Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge.
Julg B, Tartaglia LJ, Keele BF, Wagh K, Pegu A, Sok D, Abbink P, Schmidt SD, Wang K, Chen X, Joyce MG, Georgiev IS, Choe M, Kwong PD, Doria-Rose NA, Le K, Louder MK, Bailer RT, Moore PL, Korber B, Seaman MS, Abdool Karim SS, Morris L, Koup RA, Mascola JR, Burton DR, Barouch DH.
Sci Transl Med. 2017 Sep 6;9(406).

Virological and immunological outcome of treatment interruption in HIV-1-infected subjects vaccinated with MVA-B.
Rosás-Umbert M, Mothe B, Noguera-Julian M, Bellido R, Puertas MC, Carrillo J, Rodriguez C, Perez-Alvarez N, Cobarsí P, Gomez CE, Esteban M, Jímenez JL, García F, Blanco J, Martinez-Picado J, Paredes R, Brander C.
PLoS One. 2017 Sep 27;12(9):e0184929.

The Molecular Basis for Human Immunodeficiency Virus Latency.
Mbonye U, Karn J.
Annu Rev Virol. 2017 Sep 29;4(1):261-285.

New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV.
Carrillo MA, Zhen A, Zack JA, Kitchen SG.
Transl Res. 2017 Sep;187:83-92.
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The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes.
Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M.
Mol Cell. 2017 Sep 21;67(6):1001-1012.


August 2017

Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys.
Julg B, Pegu A, Abbink P, Liu J, Brinkman A, Molloy K, Mojta S, Chandrashekar A, Callow K, Wang K, Chen X, Schmidt SD, Huang J, Koup RA, Seaman MS, Keele BF, Mascola JR, Connors M, Barouch DH.
J Virol. 2017 Jul 27;91(16).
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Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines.
Boehm D, Ott M.
Bio Protoc. 2017 May 20;7(10).

Fcγ Receptor Function and the Design of Vaccination Strategies.
Bournazos S, Ravetch JV.
Immunity. 2017 Aug 15;47(2):224-233.

Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients.
Montserrat M, Plana M, Guardo AC, Andrés C, Climent N, Gallart T, Leal L, Gatell JM, Sánchez-Palomino S, García F.
AIDS. 2017 Aug 24;31(13):1895-1897.
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Evaluation of the Aptima HIV-1 Quant Dx Assay for HIV-1 RNA Quantitation in Different Biological Specimen Types.
Yek C, Massanella M, Peling T, Lednovich K, Nair SV, Worlock A, Vargas M, Gianella S, Ellis RJ, Strain MC, Busch MP, Nugent CT, Richman DD.
J Clin Microbiol. 2017 Aug;55(8):2544-2553.

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers.
de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF, Michaud HA.
Retrovirology. 2017 Aug 22;14(1):41.


July 2017

Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.
Miller CM, Akiyama H, Agosto LM, Emery A, Ettinger CR, Swanstrom RI, Henderson AJ, Gummuluru S.
J Virol. 2017 Jun 9;91(13).

Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation.
Kim JT, Liu Y, Kulkarni RP, Lee KK, Dai B, Lovely G, Ouyang Y, Wang P, Yang L, Baltimore D.
Sci Immunol. 2017 Jul 21;2(13).

Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression.
Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM.
AIDS Res Hum Retroviruses. 2017 Jul;33(7):658-667.

HIV Antibody Level as a Marker of HIV Persistence and Low-Level Viral Replication.
Keating SM, Pilcher CD, Jain V, Lebedeva M, Hampton D, Abdel-Mohsen M, Deng X, Murphy G, Welte A, Facente SN, Hecht F, Deeks SG, Pillai SK, Busch MP.
J Infect Dis. 2017 Jul 1;216(1):72-81.

Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells.
Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR.
Cell Rep. 2017 Jul 25;20(4):984-998.

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals.
Koelsch KK, Rasmussen TA, Hey-Nguyen WJ, Pearson C, Xu Y, Bailey M, Marks KH, Sasson SC, Taylor MS, Tantau R, Obeid S, Milner B, Morrissey O, Pinto AN, Suzuki K, Busch MP, Keating SM, Kaiser P, Yukl S, Wong JK, Hiener BM, Palmer S, Zaunders J, Post JJ, Chan DJ, Avery S, Milliken ST, Kelleher AD, Lewin SR, Cooper DA.
J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):328-337.
READ MORE: Understanding Exactly How the ‘Berlin Patient’ Was Cured

The loss of CCR6+ and CD161+ CD4+ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques.
McGary CS, Alvarez X, Harrington S, Cervasi B, Ryan ES, Iriele RI, Paganini S, Harper JL, Easley K, Silvestri G, Ansari AA, Lichterfeld M, Micci L, Paiardini M.
Mucosal Immunol. 2017 Jul;10(4):1082-1096.

Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed.
Pillai SK, Deeks SG.
Trends Immunol. 2017 Jul;38(7):457-458.


June 2017

High-throughput Characterization of HIV-1 Reservoir Reactivation Using a Single-Cell-in-Droplet PCR Assay.
Yucha RW, Hobbs KS, Hanhauser E, Hogan LE, Nieves W, Ozen MO, Inci F, York V, Gibson EA, Thanh C, Shafiee H, El Assal R, Kiselinova M, Robles YP, Bae H, Leadabrand KS, Wang S, Deeks SG, Kuritzkes DR, Demirci U, Henrich TJ.
EBioMedicine. 2017 Jun;20:217-229.

BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH, Kaufmann DE, Smith AB 3rd, Sodroski J, Sauter D, Kirchhoff F, Gee K, Neil SJ, Evans DT, Finzi A.
J Virol. 2017 May 12;91(11).

Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.
Forsell MNE, Kvastad L, Sedimbi SK, Andersson J, Karlsson MCI.
Front Immunol. 2017 Jun 30;8:738.

New challenges in therapeutic vaccines against HIV infection.
Leal L, Lucero C, Gatell JM, Gallart T, Plana M, García F.
Expert Rev Vaccines. 2017 Jun;16(6):587-600.

Post-treatment control in an adult with perinatally acquired HIV following cessation of antiretroviral therapy.
McMahon JH, Chang J, Tennakoon S, Dantanarayana A, Solomon A, Cherry C, Doherty R, Cameron P, Lewin SR.
AIDS. 2017 Jun 1;31(9):1344-1346.

Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection.
Vibholm L, Schleimann MH, Højen JF, Benfield T, Offersen R, Rasmussen K, Olesen R, Dige A, Agnholt J, Grau J, Buzon M, Wittig B, Lichterfeld M, Petersen AM, Deng X, Abdel-Mohsen M, Pillai SK, Rutsaert S, Trypsteen W, De Spiegelaere W, Vandekerchove L, Østergaard L, Rasmussen TA, Denton PW, Tolstrup M, Søgaard OS.
Clin Infect Dis. 2017 Jun 15;64(12):1686-1695.
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May 2017

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M.
Cell Host
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April 2017

A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads.
Charlins P, Schmitt K, Remling-Mulder L, Hogan LE, Hanhauser E, Hobbs KS, Hecht F, Deeks SG, Henrich TJ, Akkina R.
Virology. 2017 Apr 19;507:135-139.
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Signaling by Antibodies: Recent Progress.
Bournazos S, Wang TT, Dahan R, Maamary J, Ravetch JV.
Annu Rev Immunol. 2017 Apr 26;35:285-311.

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.
Pollack RA, Jones RB, Pertea M, Bruner KM, Martin AR, Thomas AS, Capoferri AA, Beg SA, Huang SH, Karandish S, Hao H, Halper-Stromberg E, Yong PC, Kovacs C, Benko E, Siliciano RF, Ho YC.
Cell Host Microbe. 2017 Apr 12;21(4):494-506.

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics.
Hosmane NN, Kwon KJ, Bruner KM, Capoferri AA, Beg S, Rosenbloom DI, Keele BF, Ho YC, Siliciano JD, Siliciano RF.
J Exp Med. 2017 Apr 3;214(4):959-972.

Assays for precise quantification of total (including short) and elongated HIV-1 transcripts.
Kaiser P, Joshi SK, Kim P, Li P, Liu H, Rice AP, Wong JK, Yukl SA.
J Virol Methods. 2017 Apr;242:1-8.


March 2017

Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.
Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A.
J Virol. 2017 Feb 14;91(5). pii: e02219-16.
READ MORE: Exploring the HIV Envelope in Pursuit of an HIV Vaccine

February 2017

Association of Arterial and Lymph Node Inflammation With Distinct Inflammatory Pathways in Human Immunodeficiency Virus Infection.
Tawakol A, Ishai A, Li D, Takx RA, Hur S, Kaiser Y, Pampaloni M, Rupert A, Hsu D, Sereti I, Fromentin R, Chomont N, Ganz P, Deeks SG, Hsue PY.
JAMA Cardiol. 2017 Feb 1;2(2):163-171.
READ MORE: Aging with HIV: Concerns About Accelerated Heart Disease  

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency.
Nguyen K, Das B, Dobrowolski C, Karn J.
MBio. 2017 Feb 28;8(1). pii: e00133-17.


January 2017

The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure?
Deeks SG, Odorizzi PM, Sekaly RP.
J Clin Invest. 2017 Jan 3;127(1):103-105.
READ MORE: Understanding the ‘Interferon Paradox:’ A Novel Approach to Eradicating HIV

A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
Bloch N, Gläsker S, Sitaram P, Hofmann H, Shepard CN, Schultz ML, Kim B, Landau NR.
J Biol Chem. 2017 Jan 20;292(3):1068-1080.

Cancer therapies in HIV cure research.
Rasmussen TA, Anderson JL, Wightman F, Lewin SR.
Curr Opin HIV AIDS. 2017 Jan;12(1):96-104.


December 2016

Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages.
Agosto LM, Hirnet JB, Michaels DH, Shaik-Dasthagirisaheb YB, Gibson FC, Viglianti G, Henderson AJ.
Virology. 2016 Dec;499:72-81.

TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes.
Hofmann H, Vanwalscappel B, Bloch N, Landau NR.
Retrovirology. 2016 Dec 1;13(1):83.

Engineering HIV-Specific Immunity with Chimeric Antigen Receptors.
Kitchen SG, Zack JA.
AIDS Patient Care STDS. 2016 Dec;30(12):556-561.

Euphorbia Kansui Reactivates Latent HIV.
Cary DC, Fujinaga K, Peterlin BM.
PLoS One. 2016 Dec 15;11(12):e0168027

The mTOR Complex Controls HIV Latency.
Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E.
Cell Host Microbe. 2016 Dec 14;20(6):785-797.
READ MORE: Exploring the HIV Envelope in Pursuit of an HIV Vaccine

November 2016

Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus.
Ding S, Medjahed H, Prévost J, Coutu M, Xiang SH, Finzi A.
J Virol. 2016;90(22):10065-10073.


Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.
Pinzone MR, Graf E, Lynch L, McLaughlin B, Hecht FM, Connors M, Migueles SA, Hwang WT, Nunnari G, O'Doherty U.
J Virol. 2016;90(23):10436-10445.
READ MORE: Following HIV Reservoirs: Impact of ART and Its Timing


Quantitative evaluation of the antiretroviral efficacy of dolutegravir.
Laskey SB, Siliciano RF.
JCI Insight. 2016;1(19):e90033.

October 2016

Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents.
Delagrèverie HM, Delaugerre C, Lewin SR, Deeks SG, Li JZ.
Open Forum Infect Dis. 2016 Oct 7;3(4):ofw189.


Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.
Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.
EBioMedicine. 2016 Oct;12:208-218.


Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.
Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J.
MBio. 2016 Oct 25;7(5). pii: e01598-16.


Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.
Mavigner M, Lee ST, Habib J, Robinson C, Silvestri G, O'Doherty U, Chahroudi A.
J Virus Erad. 2016 Oct 5;2(4):219-226.


Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay.
Trypsteen W, Mohammadi P, Van Hecke C, Mestdagh P, Lefever S, Saeys Y, De Bleser P, Vandesompele J, Ciuffi A, Vandekerckhove L, De Spiegelaere W.
Sci Rep. 2016 Oct 26;6:36111.


CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.
Leong YA, Chen Y, Ong HS, Wu D, Man K, Deleage C, Minnich M, Meckiff BJ, Wei Y, Hou Z, Zotos D, Fenix KA, Atnerkar A, Preston S, Chipman JG, Beilman GJ, Allison CC, Sun L, Wang P, Xu J, Toe JG, Lu HK, Tao Y, Palendira U, Dent AL, Landay AL, Pellegrini M, Comerford I, McColl SR, Schacker TW, Long HM, Estes JD, Busslinger M, Belz GT, Lewin SR, Kallies A, Yu D.
Nat Immunol. 2016 Oct;17(10):1187-96.

September 2016

Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages.
Agosto LM, Hirnet JB, Michaels DH, Shaik-Dasthagirisaheb YB, Gibson FC, Viglianti G, Henderson AJ.
Virology. 2016 Sep 15;499:72-81.

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado GG, Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE.
Cell Host Microbe. 2016 Sep 14;20(3):368-80.

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.
Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.
EBioMedicine. 2016 Sep 9. pii: S2352-3964(16)30412-1. 

Standard vaccines increase HIV-1 transcription during antiretroviral therapy.
Yek C, Gianella S, Plana M, Castro P, Scheffler K, García F, Massanella M, Smith DM.
AIDS. 2016 Sep 24;30(15):2289-98.

Antiretroviral therapy suppressed participants with low CD4+ T-cell counts segregate according to opposite immunological phenotypes.
Pérez-Santiago J, Ouchi D, Urrea V, Carrillo J, Cabrera C, Villà-Freixa J, Puig J, Paredes R, Negredo E, Clotet B, Massanella M, Blanco J.
AIDS. 2016 Sep 24;30(15):2275-87.
READ MORE:  More Than One Way to Activate a Virus

Broad activation of latent HIV-1 in vivo.
Barton K, Hiener B, Winckelmann A, Rasmussen TA, Shao W, Byth K, Lanfear R, Solomon A, McMahon J, Harrington S, Buzon M, Lichterfeld M, Denton PW, Olesen R, Østergaard L, Tolstrup M, Lewin SR, Søgaard OS, Palmer S.
Nat Commun. 2016 Sep 8;7:12731.
READ MORE:  More Than One Way to Activate a Virus

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.
Hansen EC, Ransom M, Hesselberth JR, Hosmane NN, Capoferri AA, Bruner KM, Pollack RA, Zhang H, Drummond MB, Siliciano JM, Siliciano R, Stivers JT.
Elife. 2016 Sep 20;5. pii: e18447.

Defective proviruses rapidly accumulate during acute HIV-1 infection.
Bruner KM, Murray AJ, Pollack RA, Soliman MG, Laskey SB, Capoferri AA, Lai J, Strain MC, Lada SM, Hoh R, Ho YC, Richman DD, Deeks SG, Siliciano JD, Siliciano RF.
Nat Med. 2016 Sep;22(9):1043-9.

August 2016

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.
Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD.
PLoS One. 2016 Aug 2;11(8):e0160192.

Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring.
Lifson MA, Ozen MO, Inci F, Wang S, Inan H, Baday M, Henrich TJ, Demirci U.
Adv Drug Deliv Rev. 2016 Aug 1;103:90-104.

Identification of Siglec-1 null individuals infected with HIV-1.
Martinez-Picado J, McLaren PJ, Erkizia I, Martin MP, Benet S, Rotger M, Dalmau J, Ouchi D, Wolinsky SM, Penugonda S, Günthard HF, Fellay J, Carrington M, Izquierdo-Useros N, Telenti A.
Nat Commun. 2016 Aug 11;7:12412.

T-cell therapies for HIV: Preclinical successes and current clinical strategies.
Patel S, Jones RB, Nixon DF, Bollard CM.
Cytotherapy. 2016 Aug;18(8):931-42.

Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality.
Laskey SB, Pohlmeyer CW, Bruner KM, Siliciano RF.
PLoS Pathog. 2016 Aug 5;12(8):e1005689.

In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.
Nakaya Y, Stavrou S, Blouch K, Tattersall P, Ross SR.
J Virol. 2016 Aug 12;90(17):8005-12.

July 2016

HIV integration and the establishment of latency in CCL19-treated resting CD4(+) T cells require activation of NF-κB.
Saleh S, Lu HK, Evans V, Harisson D, Zhou J, Jaworowski A, Sallmann G, Cheong KY, Mota TM, Tennakoon S, Angelovich TA, Anderson J, Harman A, Cunningham A, Gray L, Churchill M, Mak J, Drummer H, Vatakis DN, Lewin SR, Cameron PU.
Retrovirology. 2016 Jul 26;13(1):49.

Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques.
Cartwright EK, Palesch D, Mavigner M, Paiardini M, Chahroudi A, Silvestri G.
J Virol. 2016 Jul 11;90(15):6699-708.

Animal models to achieve an HIV cure.
Kumar N, Chahroudi A, Silvestri G.
Curr Opin HIV AIDS. 2016 Jul;11(4):432-41.

Strategies for targeting residual HIV infection.
Chomont N, Perreau M.
Curr Opin HIV AIDS. 2016 Jul;11(4):359-61.

Persistent HIV-1 replication during antiretroviral therapy.
Martinez-Picado J, Deeks SG.
Curr Opin HIV AIDS. 2016 Jul;11(4):417-23.

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.
Fromentin R, Bakeman W, Lawani MB, Khoury G, Hartogensis W, DaFonseca S, Killian M, Epling L, Hoh R, Sinclair E, Hecht FM, Bacchetti P, Deeks SG, Lewin SR, Sékaly RP, Chomont N.
PLoS Pathog. 2016 Jul 14;12(7):e1005761.

Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation.
Li P, Kaiser P, Lampiris HW, Kim P, Yukl SA, Havlir DV, Greene WC, Wong JK.
Nat Med. 2016 Jul;22(7):807-11.

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model.
Zhen A, Rezek V, Youn C, Rick J, Lam B, Chang N, Zack J, Kamata M, Kitchen S.
J Vis Exp. 2016 Jul 2;(113).

Shocking HIV out of hiding: where are we with clinical trials of latency reversing agents?
Rasmussen TA, Lewin SR.
Curr Opin HIV AIDS. 2016 Jul;11(4):394-401.

Adapting SHIVs In Vivo Selects for Envelope-Mediated Interferon-α Resistance.
Boyd DF, Sharma A, Humes D, Cheng-Mayer C, Overbaugh J.
PLoS Pathog. 2016 Jul 11;12(7):e1005727

The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence.
Murray AJ, Kwon KJ, Farber DL, Siliciano RF.
J Immunol. 2016 Jul 15;197(2):407-17.

Tissue reservoirs of HIV.
Wong JK, Yukl SA.
Curr Opin HIV AIDS. 2016 Jul;11(4):362-70.

June 2016

Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency.
Bournazos S, Gazumyan A, Seaman MS, Nussenzweig MC, Ravetch JV.
Cell. 2016 Jun 16;165(7):1609-20.

Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART.
Dan JM, Massanella M, Smith DM, Spina CA, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S.
J Acquir Immune Defic Syndr. 2016 Jun 1;72(2):133-7.

Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis.
Li Q, Karim AF, Ding X, Das B, Dobrowolski C, Gibson RM, Quiñones-Mateu ME, Karn J, Rojas RE.
Sci Rep. 2016 Jun 14;6:27566.

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Kong L, He L, de Val N, Vora N, Morris CD, Azadnia P, Sok D, Zhou B, Burton DR, Ward AB, Wilson IA, Zhu J.
Nat Commun. 2016 Jun 28;7:12040.

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK.
PLoS Pathog. 2016 Jun 2;12(6):e1005677.

Immunologic profiles distinguish aviremic HIV-infected adults.
Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW.
AIDS. 2016 Jun 19;30(10):1553-62.

The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model.
Cadena C, Stavrou S, Manzoni T, Iyer SS, Bibollet-Ruche F, Zhang W, Hahn BH, Browne EP, Ross SR.
Retrovirology. 2016 Jun 30;13(1):45.

May 2016

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.
Lu CL, Murakowski DK, Bournazos S, Schoofs T, Sarkar D, Halper-Stromberg A, Horwitz JA, Nogueira L, Golijanin J, Gazumyan A, Ravetch JV, Caskey M, Chakraborty AK, Nussenzweig MC.
Science. 2016 May 20;352(6288):1001-4

HIV-1 Reservoirs During Suppressive Therapy.
Barton K, Winckelmann A, Palmer S.
Trends Microbiol. 2016 May;24(5):345-55.

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.
Tully DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M, Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K, McGrath G, Bazner SB, Tinsley J, Lennon NJ, Henn MR, Brumme ZL, Norris PJ, Rosenberg ES, Mayer KH, Jessen H, Kosakovsky Pond SL, Walker BD, Altfeld M, Carlson JM, Allen TM.
PLoS Pathog. 2016 May 10;12(5):e1005619.


April 2016

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.
Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL.
Nat Med. 2016 Apr;22(4):362-8.

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.
Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BD.
PLoS Pathog. 2016 Apr 15;12(4):e1005545.

Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Kong L, Ju B, Chen Y, He L, Ren L, Liu J, Hong K, Su B, Wang Z, Ozorowski G, Ji X, Hua Y, Chen Y, Deller MC, Hao Y, Feng Y, Garces F, Wilson R, Dai K, O'Dell S, McKee K, Mascola JR, Ward AB, Wyatt RT, Li Y, Wilson IA, Zhu J, Shao Y.
Immunity. 2016 Apr 19;44(4):939-50.

How to Define the Latent Reservoir: Tools of the Trade.
Barton KM, Palmer SE.
Curr HIV/AIDS Rep. 2016 Apr;13(2):77-84.

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV.
Hill AL, Rosenbloom D, Goldstein E3 Hanhauser E, Kuritzkes DR, Siliciano RF, Henrich TJ.
PLoS Pathog. 2016 Apr 27;12(4):e1005535.


March 2016

Residual inflammation and viral reservoirs: alliance against an HIV cure.
Massanella M, Fromentin R, Chomont N.
Curr Opin HIV AIDS. 2016 Mar;11(2):234-41.
READ MORE: Breaking a Vicious Circle - Controlling HIV Reservoirs by Targeting Inflammation

CCR5-Δ32 Heterozygosity, HIV-1 Reservoir Size, and Lymphocyte Activation in Individuals Receiving Long-term Suppressive Antiretroviral Therapy.
Henrich TJ, Hanhauser E, Harrison LJ, Palmer CD, Romero-Tejeda M, Jost S, Bosch RJ, Kuritzkes DR.
J Infect Dis. 2016 Mar 1;213(5):766-70.

Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection.
Gianella S, Anderson CM, Var SR, Oliveira MF, Lada SM, Vargas MV, Massanella M, Little SJ, Richman DD, Strain MC, Pérez-Santiago J, Smith DM.
J Virol. 2016 Mar 28;90(8):3944-52.

Macrophages and HIV-1: An Unhealthy Constellation.
Sattentau QJ, Stevenson M.
Cell Host Microbe. 2016 Mar 9;19(3):304-10.


February 2016

Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1.
Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM, Gallart T, Mallol J, Gatell JM, Lluís C, Franco R, McCormick PJ, Climent N.
J Leukoc Biol. 2016 Feb;99(2):349-59.

HIV-specific CD8+ T cells and HIV eradication.
Jones RB, Walker BD.
J Clin Invest. 2016 Feb 1;126(2):455-63.

Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques.
Ryan ES, Micci L, Fromentin R, Paganini S, McGary CS, Easley K, Chomont N, Paiardini M.
PLoS Pathog. 2016 Feb 1;12(2):e1005412.
READ MORE: Attacking HIV in the Gut

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage.
Evans TI, Li H, Schafer JL, Klatt NR, Hao XP, Traslavina RP, Estes JD, Brenchley JM, Reeves RK.
J Infect Dis. 2016 Feb 1;213(3):361-9.

Recent developments in the effort to cure HIV infection: going beyond N = 1.
Siliciano JD, Siliciano RF.
J Clin Invest. 2016 Feb 1;126(2):409-14.


January 2016

Ethics of ART interruption after stem-cell transplantation.
Sugarman J, Lewin SR, Henrich TJ, Rasmussen TA.
Lancet HIV. 2016 Jan;3(1):e8-e10.
READ MORE: The Science, and Ethics, of Stopping ART in Assessing Possible HIV Cures

Analysis of HIV-1 Gag-RNA Interactions in Cells and Virions by CLIP-seq.
Kutluay SB, Bieniasz PD.
Methods Mol Biol. 2016;1354:119-31

Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure.
Martin AR, Siliciano RF.
Annu Rev Med. 2016 Jan 14;67:215-28

December 2015

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.
Cubas R, van Grevenynghe J, Wills S, Kardava L, Santich BH, Buckner CM, Muir R, Tardif V, Nichols C, Procopio F, He Z, Metcalf T, Ghneim K, Locci M, Ancuta P, Routy JP, Trautmann L, Li Y, McDermott AB, Koup RA, Petrovas C, Migueles SA, Connors M, Tomaras GD, Moir S, Crotty S, Haddad EK.
J Immunol. 2015 Dec 15;195(12):5625-36.

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.
Elliott JH, McMahon JH, Chang CC, Lee SA, Hartogensis W, Bumpus N, Savic R, Roney J, Hoh R, Solomon A, Piatak M, Gorelick RJ, Lifson J, Bacchetti P, Deeks SG, Lewin SR.
Lancet HIV. 2015 Dec;2(12):e520-9.

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1.
Rosenbloom DI, Elliott O, Hill AL, Henrich TJ, Siliciano JM, Siliciano RF. 
Open Forum Infect Dis. 2015 Aug 26;2(4):ofv123.

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.
Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M.
J Clin Invest. 2015 Dec 1;125(12):4497-513. 
READ MORE: Reducing Viral Reservoirs with Immune-Based Therapy

Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women.
Shen R, Achenbach J, Shen Y, Palaia J, Rahkola JT, Nick HJ, Smythies LE, McConnell M, Fowler MG, Smith PD, Janoff EN.
PLoS One. 2015 Dec 17;10(12):e0145150.


November 2015

Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects.
Burbelo PD, Klimavicz JS, Deeks SG, Kovacs JA, Ragheb JA.
PLoS One. 2015 Nov 23;10(11):e0127662.

Multiplexed highly-accurate DNA sequencing of closely-related HIV-1 variants using continuous long reads from single molecule, real-time sequencing.
Dilernia DA, Chien JT, Monaco DC, Brown MP, Ende Z, Deymier MJ, Yue L, Paxinos EE, Allen S, Tirado-Ramos A, Hunter E.
Nucleic Acids Res. 2015 Nov 16;43(20):e129

CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.
Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM.
Cell Host Microbe. 2015 Nov 11;18(5):560-70.

Central memory CD4+ T cells are preferential targets of double infection by HIV-1.
Haqqani AA, Marek SL, Kumar J, Davenport M, Wang H, Tilton JC.
Virol J. 2015 Nov 11;12(1):184.

Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity.
Wahl A, Baker C, Spagnuolo RA, Stamper LW, Fouda GG, Permar SR, Hinde K, Kuhn L, Bode L, Aldrovandi GM, Garcia JV.
J Virol. 2015 Nov 1;89(21):10868-78.
READ MORE: Breast Milk Yields Clues to Natural Inhibitors of HIV


October 2015

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat.
Olesen R, Vigano S, Rasmussen TA, Søgaard OS, Ouyang Z, Buzon M, Bashirova A, Carrington M, Palmer S, Brinkmann CR, Yu XG, Østergaard L, Tolstrup M, Lichterfeld M. J Virol. 2015 Oct 15;89(20):10176-89 
READ MORE: A Prominent Role for Innate Immunity in Eradicating HIV

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs.
Malatinkova E, De Spiegelaere W, Bonczkowski P, Kiselinova M, Vervisch K, Trypsteen W, Johnson M, Verhofstede C, de Looze D, Murray C, Kinloch-de Loes S, Vandekerckhove L. Elife. 2015 Oct 6;4. doi: 10.7554/eLife.09115.


September 2015

Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques.
Chowdhury A, Hayes TL, Bosinger SE, Lawson BO, Vanderford T, Schmitz JE, Paiardini M, Betts M, Chahroudi A, Estes JD, Silvestri G.
J Virol. 2015 Sep 1;89(17):8677-86.  
READ MORE: Taking Control of HIV

The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys.
Etienne L, Bibollet-Ruche F, Sudmant PH, Wu LI, Hahn BH, Emerman M.
PLoS Pathog. 2015 Sep 22;11(9):e1005149.  

HIV-1 Reservoir Dynamics after Vaccination and Antiretroviral Therapy Interruption Are Associated with Dendritic Cell Vaccine-Induced T Cell Responses.
Andrés C, Plana M, Guardo AC, Alvarez-Fernández C, Climent N, Gallart T, León A, Clotet B, Autran B, Chomont N, Gatell JM, Sánchez-Palomino S, García F.
J Virol. 2015 Sep 15;89(18):9189-99.  

Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir.
Bosman KJ, Nijhuis M, van Ham PM, Wensing AM, Vervisch K, Vandekerckhove L, De Spiegelaere W.
Sci Rep. 2015 Sep 9;5:13811.  

Antigen-specific NK cell memory in rhesus macaques.
Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, von Andrian UH, Barouch DH.
Nat Immunol. 2015 Sep;16(9):927-32;
READ MORE: Natural Killers Adapt

Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.
Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M.
Virology. 2015 Sep;483:185-202.

Inhibition of HIV infection by caerin 1 antimicrobial peptides.
VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.
Peptides. 2015 Sep;71:296-303. doi: 10.1016/j.peptides.2015.05.004. Epub 2015 May 27.

August 2015

Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S.
J Infect Dis. 2015 Aug 15;212(4):596-607
READ MORE: Division or Multiplication: Exploring the Maintenance of the HIV Reservoir  

July 2015

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency.
Mousseau G, Kessing CF, Fromentin R, Trautmann L, Chomont N, Valente ST.
MBio. 2015 Jul 7;6(4). pii: e00465-15.
READ MORE: Stabilize or Stimulate? A New Approach to Attacking the HIV Reservoir   

Robust regression methods for real-time polymerase chain reaction.
Trypsteen W, De Neve J, Bosman K, Nijhuis M, Thas O, Vandekerckhove L, De Spiegelaere W.
Anal Biochem. 2015 Jul 1;480:34-6. doi: 10.1016/j.ab.2015.04.001  

Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-Infected Lymph Nodes Associated with In Situ Differentiation and Functional Anergy.
Schafer JL, Li H, Evans TI, Estes JD, Reeves RK.
J Virol. 2015 Jul 1;89(13):6887-94.   

A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.
Seamon KJ, Stivers JT.
J Biomol Screen. 2015 Jul;20(6):801-9.

ddpcRquant: threshold determination for single channel droplet digital PCR experiments.
Trypsteen W, Vynck M, De Neve J, Bonczkowski P, Kiselinova M, Malatinkova E, Vervisch K, Thas O, Vandekerckhove L, De Spiegelaere W.
Anal Bioanal Chem. 2015 Jul;407(19):5827-34.

June 2015

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.
Mbonye UR, Wang B, Gokulrangan G, Chance MR, Karn J.
Proteomics. 2015 Jun;15(12):2078-86.

Bone Marrow-Imprinted Gut-Homing of Plasmacytoid Dendritic Cells (pDCs) in Acute Simian Immunodeficiency Virus Infection Results in Massive Accumulation of Hyperfunctional CD4+ pDCs in the Mucosae.
Li H, Evans TI, Gillis J, Connole M, Reeves RK.
J Infect Dis. 2015 Jun 1;211(11):1717-25.
READ MORE: Are Early Immune Defenses Helping HIV Flourish?  

May 2015

Animal models in HIV-1 protection and therapy.
Hessell AJ, Haigwood NL.
Curr Opin HIV AIDS. 2015 May;10(3):170-6.

Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32.
Henrich TJ, Hanhauser E, Hu Z, Stellbrink HJ, Noah C, Martin JN, Deeks SG, Kuritzkes DR, Pereyra F.
AIDS. 2015 May 15;29(8):867-76.

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells.
Pino M, Erkizia I, Benet S, Erikson E, Fernández-Figueras MT, Guerrero D, Dalmau J, Ouchi D, Rausell A, Ciuffi A, Keppler OT, Telenti A, Kräusslich HG, Martinez-Picado J, Izquierdo-Useros N.
Retrovirology. 2015 May 7;12:37.

CD4 mimetics sensitize HIV-1-infected cells to ADCC.
Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB 3rd, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A.
Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94.
READ MORE: Exposing HIV-Infected Cells to Antibody Attack

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.
Laird GM, Bullen CK, Rosenbloom DI, Martin AR, Hill AL, Durand CM, Siliciano JD, Siliciano RF.
J Clin Invest. 2015 May 1;125(5):1901-12.
READ MORE: To Reverse HIV Latency, Two Drugs Are Better Than One

Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.
Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M.
Virology. 2015 May 13;483:185-202.

April 2015

Molecular Determinants for Recognition of Divergent SAMHD1 Proteins by the Lentiviral Accessory Protein Vpx.
Schwefel D, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN, Taylor IA.
Cell Host Microbe. 2015 Apr 8;17(4):489-99. 

Towards an HIV-1 cure: measuring the latent reservoir.
Bruner KM, Hosmane NN, Siliciano RF.
Trends Microbiol. 2015 Apr;23(4):192-203.
READ MORE: Better Tools Needed to Reach a Cure  

March 2015

T Memory Stem Cells and HIV: a Long-Term Relationship.
Chahroudi A, Silvestri G, Lichterfeld M.
Curr HIV/AIDS Rep. 2015 Mar;12(1):33-40. doi: 10.1007/s11904-014-0246-4.
READ MORE: Self-Sustaining Reservoirs of HIV  

February 2015

Select host restriction factors are associated with HIV persistence during antiretroviral therapy.
Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerham LR, Pilcher CD, Hecht FM, Liegler T, Richman DD, Deeks SG, Pillai SK.
AIDS. 2015 Feb 20;29(4):411-20
READ MORE: Restricting HIV Reservoir Size: Lessons from Patients

Accurate Quantification of Episomal HIV-1 Two-Long Terminal Repeat Circles by Use of Optimized DNA Isolation and Droplet Digital PCR.
Malatinkova E, Kiselinova M, Bonczkowski P, Trypsteen W, Messiaen P, Vermeire J, Verhasselt B, Vervisch K, Vandekerckhove L, De Spiegelaere W.
J Clin Microbiol. 2015 Feb;53(2):699-701.

January 2015

How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?
Ananworanich J, Dubé K, Chomont N.
Curr Opin HIV AIDS. 2015 Jan;10(1):18-28.
READ MORE: Boosting Killer T cells to Eliminate HIV Reservoirs

Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope.
Doores KJ, Kong L, Krumm SA, Le KM, Sok D, Laserson U, Garces F, Poignard P, Wilson IA, Burton DR.
J Virol. 2015 Jan 15;89(2):1105-18.
NB: acknowledgement correction including amfAR:

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF.
Nature. 2015 Jan 15;517(7534):381-5.
READ MORE: Boosting Killer T cells to Eliminate HIV Reservoirs  

December 2014

The Immunologic Effects of Mesalamine in Treated HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery: A Randomized Crossover Trial.
Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW.
PLoS One. 2014 Dec 29;9(12):e116306.  

Macrophage Infection via Selective Capture of HIV-1-Infected CD4(+) T Cells.
Baxter AE, Russell RA, Duncan CJ, Moore MD, Willberg CB, Pablos JL, Finzi A, Kaufmann DE, Ochsenbauer C, Kappes JC, Groot F, Sattentau QJ.
Cell Host Microbe. 2014 Dec 10;16(6):711-21.  

Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents.
Persaud D, Patel K, Karalius B, Rainwater-Lovett K, Ziemniak C, Ellis A, Chen YH, Richman D, Siberry GK, Van Dyke RB, Burchett S, Seage GR 3rd, Luzuriaga K; Pediatric HIV/AIDS Cohort Study.
JAMA Pediatr. 2014 Dec 1;168(12):1138-46. 

Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy.
Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK.
J Infect Dis. 2014 Dec 1;210(11):1838-43.  

Plasmacytoid Dendritic Cells from HIV-1 Elite Controllers Maintain a Gut-Homing Phenotype Associated with Immune Activation.
Li H, Goepfert P, Reeves RK.
AIDS Res Hum Retroviruses. 2014 Dec;30(12):1213-5.  

HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission.
Shen R, Raska M, Bimczok D, Novak J, Smith PD.
J Virol. 2014 Dec 15;88(24):14258-67.  

A primary CD4(+) T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence.
Kim M, Hosmane NN, Bullen CK, Capoferri A, Yang HC, Siliciano JD, Siliciano RF.
Nat Protoc. 2014 Dec;9(12):2755-70.
READ MORE: Modeling and Controlling HIV  Reservoirs

Finding a Cure for Human Immunodeficiency Virus-1 Infection.
Blankson JN, Siliciano JD, Siliciano RF.
Infect Dis Clin North Am. 2014 Dec;28(4):633-650.  

Sulfonation pathway inhibitors block reactivation of latent HIV-1.
Murry JP, Godoy J, Mukim A, Swann J, Bruce JW, Ahlquist P, Bosque A, Planelles V, Spina CA, Young JA.
Virology. 2014 Dec;471-473:1-12.
READ MORE: Modeling and Controlling HIV  Reservoirs

November 2014

HIV-1 Envelope Glycoprotein Trimer Immunogenicity Elicited in the Presence of Human CD4 Alters the Neutralization Profile.
Forsell MN, McKee K, Feng Y, Mascola JR, Wyatt RT.
AIDS Res Hum Retroviruses. 2014 Nov;30(11):1089-98 

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy.
Elliott JH, Wightman F, Solomon A, Ghneim K, Ahlers J, Cameron MJ, Smith MZ, Spelman T, McMahon J, Velayudham P, Brown G, Roney J, Watson J, Prince MH, Hoy JF, Chomont N, Fromentin R, Procopio FA, Zeidan J, Palmer S, Odevall L, Johnstone RW, Martin BP, Sinclair E, Deeks SG, Hazuda DJ, Cameron PU, Sékaly RP, Lewin SR.
PLoS Pathog. 2014 Nov 13;10(10):e1004473 

Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies.
Vandergeeten C, Fromentin R, Merlini E, Lawani MB, DaFonseca S, Bakeman W, McNulty A, Ramgopal M, Michael N, Kim JH, Ananworanich J, Chomont N.
J Virol. 2014 Nov;88(21):12385-96. 

HIV Type 1 (HIV-1) Proviral Reservoirs Decay Continuously Under Sustained Virologic Control in HIV-1-Infected Children Who Received Early Treatment.
Luzuriaga K, Tabak B, Garber M, Chen YH, Ziemniak C, McManus MM, Murray D, Strain MC, Richman DD, Chun TW, Cunningham CK, Persaud D.
J Infect Dis. 2014 Nov 15;210(10):1529-38.
READ MORE: The Impact of Early Treatment on HIV Reservoirs in Children  

October 2014

A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.
Herschhorn A, Gu C, Espy N, Richard J, Finzi A, Sodroski JG.
Nat Chem Biol. 2014 Oct;10(10):845-52. 

CD4+ and CD8+ T Cell Activation Are Associated with HIV DNA in Resting CD4+ T Cells.
Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG.
PLoS One. 2014 Oct 23;9(10):e110731 
READ MORE: Sizing Up the HIV Reservoir

Hypogammaglobulinemia in BLT Humanized Mice - An Animal Model of Primary Antibody Deficiency
Martinez-Torres F, Nochi T, Wahl A, Garcia JV, Denton PW.
PLoS One. 2014 Oct 1;9(10):e108663.

September 2014

Lipopolysaccharide, immune activation, and liver abnormalities in HIV/hepatitis B virus (HBV)-coinfected individuals receiving HBV-active combination antiretroviral therapy.
Crane M, Avihingsanon A, Rajasuriar R, Velayudham P, Iser D, Solomon A, Sebolao B, Tran A, Spelman T, Matthews G, Cameron P, Tangkijvanich P, Dore GJ, Ruxrungtham K, Lewin SR.
J Infect Dis. 2014 Sep 1;210(5):745-51.

Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells.
Buzon MJ, Martin-Gayo E, Pereyra F, Ouyang Z, Sun H, Li JZ, Piovoso M, Shaw A, Dalmau J, Zangger N, Martinez-Picado J, Zurakowski R, Yu XG, Telenti A, Walker BD, Rosenberg ES, Lichterfeld M.
J Virol. 2014 Sep 1;88(17):10056-65.
READ MORE: Viral Reservoirs: How Low Must We Go?   

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1.
Hill AL, Rosenbloom DI, Fu F, Nowak MA, Siliciano RF.
Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13475-80.
READ MORE: Viral Reservoirs: How Low Must We Go? 

The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of Postentry Viral Events.
Lucera MB, Tilton CA, Mao H, Dobrowolski C, Tabler CO, Haqqani AA, Karn J, Tilton JC.
J Virol. 2014 Sep 15;88(18):10803-12.

August 2014

Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.
Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM.
AIDS Res Ther. 2014 Aug 5;11:27. 

Cutting Edge: An Antibody Recognizing Ancestral Endogenous Virus Glycoproteins Mediates Antibody-Dependent Cellular Cytotoxicity on HIV-1-Infected Cells.
Michaud HA, SenGupta D, de Mulder M, Deeks SG, Martin JN, Kobie JJ, Sacha JB, Nixon DF.
J Immunol. 2014 Aug 15;193(4):1544-8.
READ MORE: Innovative New Approaches to Designing HIV Vaccines

Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection.
Raska M, Czernekova L, Moldoveanu Z, Zachova K, Elliott MC, Novak Z, Hall S, Hoelscher M, Maboko L, Brown R, Smith PD, Mestecky J, Novak J.
AIDS Res Ther. 2014 Aug 1;11:23.
READ MORE: Innovative New Approaches to Designing HIV Vaccines

The use of BLT mice to investigate the immune reconstitutionin the gastrointestinal tract.
Wahl A, Garcia JV. J Immunol Methods. 410:28-33.

July 2014

Immunologic strategies for HIV-1 remission and eradication.
Barouch DH, Deeks SG.
Science. 2014 Jul 11;345(6193):169-74. 

Programmed death-1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease.
Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG.
AIDS. 2014 Jul 31;28(12):1749-58.   

HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.
Izquierdo-Useros N, Lorizate M, McLaren PJ, Telenti A, Kräusslich HG, Martinez-Picado J.
PLoS Pathog. 2014 Jul 17;10(7):e1004146  

Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1.
Shen R, Kappes JC, Smythies LE, Richter HE, Novak L, Smith PD.
J Virol. 2014 Jul 1;88(13):7683-8.
READ MORE: Unraveling the Mechanisms of Male-to-Female HIV Transmission  

June 2014

Prevention of HIV-1 transmission with postexposure prophylaxis after inadvertent infected blood transfusion.
Al-Hajjar SH, Frayha HH, Al-Hazmi M, Batawi R, McIntosh K, Sax PE, Al-Thawadi S, Al-Jumaah S, Busch MP, Hanhauser E, Kuritzkes DR, Li JZ, Henrich TJ.
AIDS. 2014 Jun 19;28(10):1539-41.

A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4(+) T Cells from Elite Controllers.
Leng J, Ho HP, Buzon MJ, Pereyra F, Walker BD, Yu XG, Chang EJ, Lichterfeld M.
Cell Host Microbe. 2014 Jun 11;15(6):717-28.
READ MORE:   How Cells Resist HIV Infection: New Clues

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies.
Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB 3rd, Wyatt R, Sodroski J.
J Virol. 2014 Jun 15;88(12):6542-6555.

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection.
Shan L, Siliciano RF.
J Clin Invest. 2014 Jun 2;124(6):2368-71.

Quantification of Integrated HIV DNA by Repetitive-Sampling Alu-HIV PCR on the Basis of Poisson Statistics.
De Spiegelaere W, Malatinkova E, Lynch L, Van Nieuwerburgh F, Messiaen P, O'Doherty U, Vandekerckhove L.
Clin Chem. 2014 Jun;60(6):886-95.

May 2014

An Example of Genetically Distinct HIV Type 1 Variants in Cerebrospinal Fluid and Plasma During Suppressive Therapy.
Dahl V, Gisslen M, Hagberg L, Peterson J, Shao W, Spudich S, Price RW, Palmer S.
J Infect Dis. 2014 May;209(10):1618-22.

HIV Antibody Characterization as a Method to Quantify Reservoir Size During Curative Interventions.
Burbelo PD, Bayat A, Rhodes CS, Hoh R, Martin JN, Fromentin R, Chomont N, Hütter G, Kovacs JA, Deeks SG.
J Infect Dis. 2014 May;209(10):1613-7.

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality.
Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG.
PLoS Pathog. 2014 May 15;10(5):e1004078

Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.
Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D.
J Virol. 2014 May;88(9):5014-28.

Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.
Sun H1, Buzon MJ, Shaw A, Berg RK, Yu XG, Ferrando-Martinez S, Leal M, Ruiz-Mateos E, Lichterfeld M.
J Infect Dis. 2014 May 1;209(9):1315-20.
READ MORE: Possible New Use for an Old Antiviral Drug in Attacking Latent HIV

BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner.
Nityanandam R, Serra-Moreno R.
PLoS Pathog. 2014 May 22;10(5):e1004151

CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression.
Tabler CO, Lucera MB, Haqqani AA, McDonald DJ, Migueles SA, Connors M, Tilton JC.
J Virol. 2014 May;88(9):4976-86.

April 2014

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.
Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF.
Nat Med. 2014 Apr;20(4):425-9.
READ MORE: Additional Approaches to Attacking the HIV Reservoir 

Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children.
Ananworanich J, Puthanakit T, Suntarattiwong P, Chokephaibulkit K, Kerr SJ, Fromentin R, Bakeman W, Intasan J, Mahanontharit A, Sirivichayakul S, Chomont N.
AIDS. 2014 Apr 24;28(7):1015-20.

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure.
Mbonye U, Karn J.
Virology. 2014 Apr;454-455C:328-339.
READ MORE: Additional Approaches to Attacking the HIV Reservoir

Positive selection of primate genes that promote HIV-1 replication.
Meyerson NR, Rowley PA, Swan CH, Le DT, Wilkerson GK, Sawyer SL.
Virology. 2014 Apr;454-455:291-8.

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides.
Laird GM, Eisele EE, Rabi SA, Nikolaeva D, Siliciano RF.
J Antimicrob Chemother. 2014 Apr;69(4):988-94.
READ MORE: Additional Approaches to Attacking the HIV Reservoir 

Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.
Sun H, Buzon MJ, Shaw A, Berg RK, Yu XG, Ferrando-Martinez S, Leal M, Ruiz-Mateos E, Lichterfeld M.
J Infect Dis. 2014 May 1;209(9):1315-20. doi: 10.1093/infdis/jit628. Epub 2013 Nov 25.

March 2014

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy.
Spivak AM, Andrade A, Eisele E, Hoh R, Bacchetti P, Bumpus NN, Emad F, Buckheit R 3rd, McCance-Katz EF, Lai J, Kennedy M, Chander G, Siliciano RF, Siliciano JD, Deeks SG.
Clin Infect Dis. 2014 Mar;58(6):883-90
READ MORE: Testing “Shock and Kill” 

February 2014

Differential Blood and Mucosal Immune Responses against an HIV-1 Vaccine Administered via Inguinal or Deltoid Injection.
Yang OO, Ibarrondo FJ, Price C, Hultin LE, Elliott J, Hultin PM, Shih R, Hausner MA, Ng HL, Hoffman J, Jamieson BD, Anton PA.
PLoS One. 2014 Feb 18;9(2):e88621
READ MORE: HIV in the Blood and Gut: Exploring the Differences   

Discordance Between Peripheral and Colonic Markers of Inflammation During Suppressive ART.
Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM.
J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):133-41.  
READ MORE: HIV in the Blood and Gut: Exploring the Differences 

HIV-1 persistence in CD4(+) T cells with stem cell-like properties.
Buzon MJ, Sun H, Li C, Shaw A, Seiss K, Ouyang Z, Martin-Gayo E, Leng J, Henrich TJ, Li JZ, Pereyra F, Zurakowski R, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M.
Nat Med. 2014 Feb;20(2):139-42. doi: 10.1038/nm.3445. Epub 2014 Jan 12. 

January 2014

Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease.
Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM.
PLoS One. 2014 Jan 21;9(1):e85613 

[The adaptation of lentiviruses to apes was a crucial step in the origin of HIV-1]. [Article in French]
Etienne L.
Med Sci (Paris). 2014 Jan;30(1):24-6

Susceptibility to CD8 T-Cell-Mediated Killing Influences the Reservoir of Latently HIV-1-Infected CD4 T Cells.
Buzon MJ, Yang Y, Ouyang Z, Sun H, Seiss K, Rogich J, Le Gall S, Pereyra F, Rosenberg ES, Yu XG, Lichterfeld M.
J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):1-9.
READ MORE: Killer Immunity and HIV Reservoirs   

Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection.
Michaud HA, de Mulder M, Sengupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF.
Retrovirology. 2014 Jan 28;11(1):10. 

Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells.
Shan L, Xing S, Yang HC, Zhang H, Margolick JB, Siliciano RF.
J Antimicrob Chemother. 2014 Jan;69(1):28-33.

A combination HIV reporter virus system for measuring post-entry event efficiency and viral outcome in primary CD4+ T cell subsets.
Tilton CA, Tabler CO, Lucera MB, Marek SL, Haqqani AA, Tilton JC.
J Virol Methods. 2014 Jan;195:164-9.

December 2013

Evans VA, Kumar N, Filali A, Procopio FA, Yegorov O, Goulet JP, Saleh S, Haddad EK, da Fonseca Pereira C, Ellenberg PC, Sekaly RP, Cameron PU, Lewin SR.
Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4(+) T Cells.
PLoS Pathog. 2013 Dec;9(12):e1003799.
READ MORE: New Clues to the Nature of HIV Reservoirs

Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4987-96.
READ MORE: New Clues to the Nature of HIV Reservoirs  

November 2013

Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG.
Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.
J Infect Dis. 2013 Nov 1;208(9):1436-42.
READ MORE: Building a Stronger HAART

Feng Y, Forsell MN, Flynn B, Adams W, Loré K, Seder R, Wyatt RT, Karlsson Hedestam GB.
Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.
Virology. 2013 Nov;446(1-2):56-65.

Wohlfeiler D, Hecht J, Volk J, Fisher Raymond H, Kennedy T, McFarland W.
How Can We Improve Online HIV and STD Prevention for Men Who Have Sex with Men? Perspectives of Hook-Up Website Owners, Website Users, and HIV/STD Directors.
AIDS Behav. 2013 Nov;17(9):3024-33.

Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M Jr, Chun TW, Strain M, Richman D, Luzuriaga K.
Absence of detectable HIV-1 viremia after treatment cessation in an infant.
N Engl J Med. 2013 Nov 7;369(19):1828-35.  

October 2013

Henrich TJ, Gandhi RT.
Early treatment and HIV-1 reservoirs: a stitch in time?
J Infect Dis. 2013 Oct 15;208(8):1189-93.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG.
Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers.
PLoS Pathog. 2013 Oct;9(10):e1003691.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered

All-trans-retinoic acid imprints expression of the gut-homing marker α4β7 while suppressing lymph node homing of dendritic cells.
Evans TI, Reeves RK
Clin Vaccine Immunol. 2013 Oct;20(10):1642-6.

September 2013

Breton G, Chomont N, Takata H, Fromentin R, Ahlers J, Filali-Mouhim A, Riou C, Boulassel MR, Routy JP, Yassine-Diab B, Sékaly RP.
Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection.
J Immunol. 2013 Sep 1;191(5):2194-204.
READ MORE: Attacking AIDS by Attacking Inflammation

August 2013

The mongoose, the pheasant, the pox, and the retrovirus.
Etienne L, Emerman M.
PLoS Biol. 2013;11(8):e1001641.

Lanxon-Cookson EC, Swain JV, Manocheewa S, Smith RA, Maust B, Kim M, Westfall D, Rolland M, Mullins JI.
Factors affecting relative fitness measurements in pairwise competition assays of human immunodeficiency viruses.
J Virol Methods. 2013 Aug 8;194(1-2):7-13.

Tan J, Sattentau QJ.
The HIV-1-containing macrophage compartment: a perfect cellular niche?
Trends Microbiol. 2013 Aug;21(8):405-12.
READ MORE: Exploring New Cell Reservoirs for HIV  

Cillo AR, Krishnan A, Mitsuyasu RT, McMahon DK, Li S, Rossi JJ, Zaia JA, Mellors JW.
Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma.
J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):438-41.

July 2013

Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D.
Broad protection against influenza infection by vectored immunoprophylaxis in mice.
Nat Biotechnol. 2013 Jul;31(7):647-52.  

Klatt NR, Chomont N, Douek DC, Deeks SG.
Imune activation and HIV persistence: implications for curative approaches to HIV infection.
Immunol Rev. 2013 Jul;254(1):326-42.
READ MORE: Working Towards a Cure

Chang CC, Crane M, Zhou J, Mina M, Post JJ, Cameron BA, Lloyd AR, Jaworowski A, French MA, Lewin SR.
HIV and co-infections.
Immunol Rev. 2013 Jul;254(1):114-42.

Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM
Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism.
Sci Transl Med. 2013 Jul 10;5(193):193ra91.
READ MORE: Working Towards a Cure  

Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG.
Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.
J Infect Dis. 2013 Jul;208(1):50-6.
READ MORE: Working Towards a Cure   

Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.
Gene Loss and Adaptation to Hominids Underlie the Ancient Origin of HIV-1.
Cell Host Microbe. 2013 Jul 17;14(1):85-92. 

Forsell MN, Soldemo M, Dosenovic P, Wyatt RT, Karlsson MC, Karlsson Hedestam GB.
Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization.
J Immunol. 2013 Jul 1;191(1):44-51. 

Sandgren KJ, Smed-Sörensen A, Forsell MN, Soldemo M, Adams WC, Liang F, Perbeck L, Koup RA, Wyatt RT, Karlsson Hedestam GB, Loré K.
Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation.
J Immunol. 2013 Jul 1;191(1):60-9.  

Kulpa DA, Brehm JH, Fromentin R, Cooper A, Cooper C, Ahlers J, Chomont N, Sékaly RP.
The immunological synapse: the gateway to the HIV reservoir.
Immunol Rev. 2013 Jul;254(1):305-25.
READ MORE: Working Towards a Cure  

Mao Y, Wang L, Gu C, Herschhorn A, Désormeaux A, Finzi A, Xiang SH, Sodroski JG.
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer.
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12438-43.  

Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat Struct Mol Biol. 2013 Jul;20(7):796-803.  

Serra-Moreno R, Zimmermann K, Stern LJ, Evans DT.
Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis.
PLoS Pathog. 2013 Jul;9(7):e1003487. 

Siliciano JD, Siliciano RF.
HIV-1 eradication strategies: design and assessment.
Curr Opin HIV AIDS. 2013 Jul;8(4):318-25.
READ MORE: Working Towards a Cure 

June 2013

Berro R, Yasmeen A, Abrol R, Trzaskowski B, Abi-Habib S, Grunbeck A, Lascano D, Goddard WA 3rd, Klasse PJ, Sakmar TP, Moore JP.
Use of G-Protein-Coupled and -Uncoupled CCR5 Receptors by CCR5 Inhibitor-Resistant and -Sensitive Human Immunodeficiency Virus Type 1 Variants.
J Virol. 2013 Jun;87(12):6569-81.
READ MORE: Purging Reservoirs of HIV

Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR.
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.
J Infect Dis. 2013 Jun 1;207(11):1694-702.
READ MORE: Researcher Reports Two HIV Patients Showing No Signs of Virus in Wake of Stem-Cell Transplants
READ MORE: Purging Reservoirs of HIV  

Pace M, O'Doherty U.
Hematopoietic stem cells and HIV infection.
J Infect Dis. 2013 Jun 15;207(12):1790-2.

Pace MJ, Graf EH, O'Doherty U.
HIV 2-long terminal repeat circular DNA is stable in primary CD4+T Cells.
Virology. 2013 Jun 20;441(1):18-21.
READ MORE: Purging Reservoirs of HIV   

Josefsson L, Palmer S, Faria NR, Lemey P, Casazza J, Ambrozak D, Kearney M, Shao W, Kottilil S, Sneller M, Mellors J, Coffin JM, Maldarelli F.
Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4(+) T-cells Contain One HIV-1 DNA Molecule.
PLoS Pathog. 2013 Jun;9(6):e1003432.  

Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG.
The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.
Blood. 2013 Jun 6;121(23):4635-46.
READ MORE: Purging Reservoirs of HIV  

Shan L, Siliciano RF.
From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication.
Bioessays. 2013 Jun;35(6):544-52.
READ MORE: Purging Reservoirs of HIV  

Shan L, Rabi SA, Laird GM, Eisele EE, Zhang H, Margolick JB, Siliciano RF.
A novel PCR assay for quantification of HIV-1 RNA.
J Virol. 2013 Jun;87(11):6521-5.
READ MORE: Purging Reservoirs of HIV  

May 2013

Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG.
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
PLoS Pathog. 2013 May;9(5):e1003347.
READ MORE: Multi-Targeted Approaches to an HIV Cure  

Vandergeeten C, Fromentin R, Dafonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sékaly RP, Chomont N.
Interleukin-7 promotes HIV persistence during antiretroviral therapy.
Blood. 2013 May 23;121(21):4321-9.  

Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM.
Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription.
J Biol Chem. 2013 May 17;288(20):14400-7.
READ MORE: Multi-Targeted Approaches to an HIV Cure

Hatano H.
Immune activation and HIV persistence: considerations for novel therapeutic interventions.
Curr Opin HIV AIDS. 2013 May;8(3):211-6.
READ MORE: Multi-Targeted Approaches to an HIV Cure

Stone D, Kiem HP, Jerome KR.
Targeted gene disruption to cure HIV.
Curr Opin HIV AIDS. 2013 May;8(3):217-23.
READ MORE: Multi-Targeted Approaches to an HIV Cure

Walsh AD, Bimber BN, Das A, Piaskowski SM, Rakasz EG, Bean AT, Mudd PA, Ericsen AJ, Wilson NA, Hughes AL, O'Connor DH, Maness NJ.
Acute Phase CD8+ T Lymphocytes against Alternate Reading Frame Epitopes Select for Rapid Viral Escape during SIV Infection.
PLoS One. 2013 May 6;8(5):e61383.  

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.
Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes.
PLoS Pathog. 2013 May;9(5):e1003338

April 2013

McNatt MW, Zang T, Bieniasz PD.
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathog. 2013 Apr;9(4):e1003299. 

Voit RA, McMahon MA, Sawyer SL, Porteus MH.
Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors.
Mol Ther. 2013 Apr;21(4):786-95
READ MORE: Stopping HIV Using a Cocktail of Genes Rather than Drugs 

March 2013

Désormeaux A, Coutu M, Medjahed H, Pacheco B, Herschhorn A, Gu C, Xiang SH, Mao Y, Sodroski J, Finzi A.
The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.
J Virol. 2013 Mar;87(5):2549-62.  

Kutluay SB, Perez-Caballero D, Bieniasz PD.
Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection.
PLoS Pathog. 2013 Mar;9(3):e1003214. 

Palmer S.
Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy.
Curr Opin HIV AIDS. 2013 Mar;8(2):87-92. 
READ MORE: Perfecting Tools to Monitor HIV Viral Loads

February 2013

Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM.
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS Res Hum Retroviruses. 2013 Feb;29(2):207-14.
READ MORE: Keeping Track of HIV Reservoirs

Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD.
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies.
PLoS Pathog. 2013 Feb;9(2):e1003174. 
READ MORE: Keeping Track of HIV Reservoirs  

January 2013

Ross MW, Nyoni J, Bowen AM, Williams ML, Kashiha JJ.
Sexual and geographic organization of men who have sex with men in a large East African city: opportunities for outreach.
BMJ Open. 2012 Nov 22;2(6) e001813.  

Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ.
Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration.
J Infect Dis. 2013 Jan; 207(2):213-22.
READ MORE: Controlling HIV After Stopping Antiretroviral Therapy  



November 2012


Hatano H, Scherzer R, Wu Y, Harvill K, Maka K, Hoh R, Sinclair E, Palmer S, Martin JN, Busch MP, Deeks SG, Hsue PY.
A Randomized Controlled Trial Assessing the Effects of Raltegravir Intensification on Endothelial Function in Treated HIV Infection.
J Acquir Immune Defic Syndr. 2012 Nov 1;61(3):317-25.


Nyoni J, Ross MW.
Factors associated with HIV testing in men who have sex with men, in Dar es Salaam, Tanzania.
Sex Transm Infect. 2012 Nov;88(7):483.
READ MORE: Increasing HIV Testing Among MSM in Africa


Mexas AM, Graf EH, Pace MJ, Yu JJ, Papasavvas E, Azzoni L, Busch MP, Di Mascio M, Foulkes AS, Migueles SA, Montaner LJ, O'Doherty U.
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.
AIDS. 2012 Nov 28;26(18):2295-2306.


Routy JP, Angel JB, Spaans JN, Trottier B, Rouleau D, Baril JG, Harris M, Trottier S, Singer J, Chomont N, Sékaly RP, Tremblay CL.
Design and Implementation of a Randomized Crossover Study of Valproic Acid and Antiretroviral Therapy to Reduce the HIV Reservoir.
HIV Clin Trials. 2012 Nov-Dec;13(6):301-7.


October 2012


Schrijvers R, Vets S, De Rijck J Malani N, Bushman FD, Debyser Z, Gijsbers R.
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.
Retrovirology. 2012 Oct 9;9:84. doi: 10.1186/1742-4690-9-84.
READ MORE: Exploring Potential New Targets for Anti-HIV Drugs  

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.
Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746.

Koh Fujinaga, Matjaz Barboric, Qintong Li, Zeping Luo, David H. Price and
B. Matija Peterlin.
PKC phosphorylates HEXIM1 and regulates P-TEFb activity.
Nucleic Acids Research, 2012, Vol. 40, No. 18: 9160-9170.
No abstract available


September 2012


Patel ES, Chang LJ.
Synergistic Effects of Interleukin-7 and Pre-T Cell Receptor Signaling in Human T Cell Development.
J J Biol Chem. 2012 Sep 28;287(40):33826-35.


Finzi A, Pacheco B, Xiang SH, Pancera M, Herschhorn A, Wang L, Zeng X, Desormeaux A, Kwong PD, Sodroski J.
Lineage-Specific Differences between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding.
J Virol. 2012 Sep;86(17):8974-86.


Schiffer JT, Aubert M, Weber ND, Mintzer E, Stone D, Jerome KR.
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections.
J Virol. 2012 Sep;86(17):8920-36.
READ MORE: Potential Cures for Other Viral Infections


Praditpornsilpa K, Avihingsanon A, Chaiwatanarat T, Chaiyahong P, Wongsabut J, Ubolyam S, Chulakadabba A, Avihingsanon Y, Ruxrungtham K, Tunsanga K, Eiam-Ong S,
Phanuphak P.
Comparisons Between Validated Estimated Glomerular Filtration Rate Equations and Isotopic Glomerular Filtration Rate in HIV Patients.
J AIDS. 2012 Sep 10;26(14):1781-8.


Eisele E, Siliciano RF.
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication.
Immunity. 2012 Sep 21;37(3):377-88.



August 2012


Sigal A, Baltimore D.
As good as it gets? The problem of HIV persistence despite antiretroviral drugs.
Cell Host Microbe. 2012 Aug 16;12(2):132-8.


July 2012


Josefsson L, Eriksson S, Sinclair E, Ho T, Killian M, Epling L, Shao W, Lewis B, Bacchetti P, Loeb L, Custer J, Poole L, Hecht FM, Palmer S.
Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.
J Infect Dis. 2012 Jul 1;206(1):28-34.
READ MORE: Defining HIV Reservoirs

Hogue IB, Llewellyn GN, Ono A.
Dynamic Association between HIV-1 Gag and Membrane Domains.
Mol Biol Int. 2012;2012:979765. Epub 2012 Jul 5.


May 2012


Merchant RC, Waxman MJ, Maher JG, Clark MA, Celada MT, Liu T, Simmons EM, Beckwith CG, Mayer KH.
Patient and Clinician Ethical Perspectives on the 2006 Centers for Disease Control and Prevention HIV Testing Methods.
Public Health Rep. 2012 May;127(3):318-29.
READ MORE: The Ethics of New HIV Testing Methods


McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.


April 2012


Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM.
Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
Genes Immun. 2012 Apr;13(3):258-67.


Gilchrist G, Blazquez A, Torrens, M.
Exploring the relationship between intimate partner violence, childhood abuse and psychiatric disorders among female drug users in Barcelona.
Advances in Dual Diagnosis. 2012 Apr;5(2):46-58.


Kirby KA, Marchand B, Ong YT, Ndongwe TP, Hachiya A, Michailidis E, Leslie MD, Sietsema DV, Fetterly TL, Dorst CA, Singh K, Wang Z, Parniak MA, Sarafianos SG.
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase.
Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.


Tun W, Kellerman S, Maimane S, Fipaza Z, Sheehy M, Vu L, Nel D.
HIV-related conspiracy beliefs and its relationships with HIV testing and unprotected sex among men who have sex with men in Tshwane (Pretoria), South Africa.
AIDS Care. 2012 Apr;24(4):459-67.
READ MORE: Homophobia and the Spread of HIV in South Africa


Vu L, Tun W, Sheehy M, Nel D.
Levels and correlates of internalized homophobia among men who have sex with men in Pretoria, South Africa.
AIDS Behav. 2012 Apr;16(3):717-23.
READ MORE: Homophobia and the Spread of HIV in South Africa


March 2012

Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R.
LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs.
PLoS Pathog. 2012 Mar;8(3):e1002558.


McCulley A, Ratner L.
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection.
Virology. 2012 May 25;427(1):67-75.


Melchers M, Bontjer I, Tong T, Chung NP, Klasse PJ, Eggink D, Montefiori DC, Gentile M, Cerutti A, Olson WC, Berkhout B, Binley JM, Moore JP, Sanders RW.
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
J Virol. 2012 Mar;86(5):2488-500.


Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF.
Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation.
immunity. 2012 Mar 23;36(3):491-501.
READ MORE: Destroying HIV Reservoirs


Tyagi M, Kashanchi F.
New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others.
Retrovirology. 2012 Mar 9;9:19.



February 2012


Roa A, Hayashi F, Yang Y, Lienlaf M, Zhou J, Shi J, Watanabe S, Kigawa T, Yokoyama S, Aiken C, Diaz-Griffero F.
RING domain mutations uncouple TRIM5a restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating.
J Virol. 2012 Feb;86(3):1717-27.


Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F.
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Nat Immunol. 2012 Feb 12;13(3):223-8.


Kiem HP, Jerome KR, Deeks SG, McCune JM.
Hematopoietic-stem-cell-based gene therapy for HIV disease.
Cell Stem Cell. 2012 Feb 3;10(2):137-47.
READ MORE: Leading the Charge in Cure Research


Banerjee K, Michael E, Eggink D, van Montfort T, Lasnik AB, Palmer KE, Sanders RW, Moore JP, Klasse PJ.
Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice.
AIDS Res Hum Retroviruses. 2012 Feb;28(2):206-14.


Xing S, Bhat S, Shroff NS, Zhang H, Lopez JA, Margolick JB, Liu JO, Siliciano RF.
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
J Antimicrob Chemother. 2012 Feb;67(2):398-403.
READ MORE: Leading the Charge in Cure Research



January 2012


Denton PW, Olesen R, Choudhary SK, Archin NM, Wahl A, Swanson MD, Chateau M, Nochi T, Krisko JF, Spagnuolo RA, Margolis DM, Garcia JV.
Generation of HIV latency in humanized BLT mice.
J Virol. 2012 Jan;86(1):630-4.


Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng YM, Liu SL, Kodama EI, Delviks-Frankenberry KA, Pathak VK, Mitsuya H, Parniak MA, Singh K, Sarafianos SG.
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Nucleic Acids Res. 2012 Jan 1;40(1):345-359.


Routy J, Tremblay C, Angel J, Trottier B, Rouleau D, Baril J, Harris M, Trottier S, Singer J, Chomont N, Sékaly R, Boulassel M.
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.
HIV Med. 2012 Jan 26.
READ MORE: “Shock and Kill” Strategy Holds Promise in the Search for a Cure


Boulassel MR, Chomont N, Pai NP, Gilmore N, Sékaly RP, Routy JP.
CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy.
J Clin Virol. 2012 Jan;53(1):29-32.



Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff.

2011 Publications

DEC 2011

Dahl V, Lee E, Peterson J, Spudich SS, Leppla I, Sinclair E, Fuchs D, Palmer S, Price RW.
Raltegravir treatment intensification does not alter cerebrospinal fluid HIV-1 infection or immunoactivation in subjects on suppressive therapy.
J Infect Dis. 2011 Dec 15;204(12):1936-45.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z.
Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting.
J Biol Chem. 2011 Dec 2;286(48):41812-25.

Vissman AT, Hergenrather KC, Rojas G, Langdon SE, Wilkin AM, Rhodes SD.
Applying the theory of planned behavior to explore HAART adherence among HIV-positive immigrant Latinos: elicitation interview results.
Patient Educ Couns. 2011 Dec;85(3):454-60.
READ MORE: Adhering to HAART: Challenges for Immigrant Latinos

Han K, Lou DI, Sawyer SL.
Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes.
PLoS Genet. 2011 Dec;7(12):e1002388.


NOV 2011

Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A, Smith AB 3rd, Sodroski JG.
An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors.
PLoS One. 2011;6(11):e26731.

Gilchrist G, Blazquez A, Torrens M.
Psychiatric, behavioural and social risk factors for HIV infection among female drug users.
AIDS Behav. 2011 Nov;15(8):1834-43.
READ MORE: Gender-Based Risks for HIV among Drug Users

Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DS.
Liposomes for HIV prophylaxis.
Biomaterials. 2011 Nov;32(33):8663-8.

van Montfort T, Eggink D, Boot M, Tuen M, Hioe CE, Berkhout B, Sanders RW.
HIV-1 N-Glycan Composition Governs a Balance between Dendritic Cell-Mediated Viral Transmission and Antigen Presentation.
J Immunol. 2011 Nov 1;187(9):4676-85.


OCT 2011

Bosque A, Famiglietti M, Weyrich AS, Goulston C, Planelles V.
Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells.
PLoS Pathog. 2011 Oct;7(10):e1002288.
READ MORE: New Insights Into Hidden Reservoirs for HIV Infection

Hogue IB, Grover JR, Soheilian F, Nagashima K, Ono A.
Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane.
J Virol. 2011 Oct;85(19):9749-66.

Saleh S, Wightman F, Ramanayake S, Alexander M, Kumar N, Khoury G, Pereira C, Purcell D, Cameron PU, Lewin SR.
Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells.
Retrovirology. 2011 Oct 12;8:80.

Eggink D, Bontjer I, Langedijk JP, Berkhout B, Sanders RW.
Resistance of human immunodeficiency virus type 1 to a third-generation fusion inhibitor requires multiple mutations in gp41 and is accompanied by a dramatic loss of gp41 function.
J Virol. 2011 Oct;85(20):10785-97. 

SEP 2011

Lienlaf M, Hayashi F, Di Nunzio F, Tochio N, Kigawa T, Yokoyama S, Diaz-Griffero F.
Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.
J Virol. 2011 Sep;85(17):8725-37.

Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DS.
Liposomes for HIV prophylaxis.
Biomaterials. 2011 Nov;32(33):8663-8.
READ MORE: A New Type of Vaginal Microbicide


AUG 2011

Pandrea I, Gaufin T, Gautam R, Kristoff J, Mandell D, Montefiori D, Keele BF, Ribeiro RM, Veazey RS, Apetrei C.
Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4 T Cells and Is Reverted by CD8 Cell Depletion.
PLoS Pathog. 2011 Aug;7(8):e1002170
READ MORE: An Animal Model for a Functional Cure for AIDS

Berro R, Klasse PJ, Lascano D, Flegler A, Nagashima KA, Sanders RW, Sakmar TP, Hope TJ, Moore JP.
Multiple CCR5 Conformations on the Cell Surface Are Used Differentially by Human Immunodeficiency Viruses Resistant or Sensitive to CCR5 Inhibitors.
J Virol. 2011 Aug;85(16):8227-40.

Denton PW, Othieno F, Martinez-Torres F, Zou W, Krisko JF, Fleming E, Zein S, Powell DA, Wahl A, Kwak YT, Welch BD, Kay MS, Payne DA, Gallay P, Appella E, Estes JD, Lu M, Garcia JV.
One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.
J Virol. 2011 Aug;85(15):7582-93.

Jin J, Li F, Mothes W.
Viral determinants of polarized assembly for the murine leukemia virus.
J Virol. 2011 Aug;85(15):7672-82.

Herbeck JT, Rolland M, Liu Y, McLaughlin S, McNevin J, Zhao H, Wong K, Stoddard JN, Raugi D, Sorensen S, Genowati I, Birditt B, McKay A, Diem K, Maust BS, Deng W, Collier AC, Stekler JD, McElrath MJ, Mullins JI.
Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processes.
J Virol. 2011 Aug;85(15):7523-34

Sanders RW.
Clinical evaluation of a soluble trimeric HIV-1 envelope glycoprotein vaccine.
Expert Rev Vaccines. 2011 Aug;10(8):1117-22.

JUL 2011

Kim YK, Mbonye U, Hokello J, Karn J.
T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway.
J Mol Biol. 2011 Jul 29;410(5):896-916.

Chukkapalli V, Ono A.
Molecular Determinants that Regulate Plasma Membrane Association of HIV-1 Gag.
J Mol Biol. 2011 Jul 22;410(4):512-24.

Josefsson L, King MS, Makitalo B, Brännström J, Shao W, Maldarelli F, Kearney MF, Hu WS, Chen J, Gaines H, Mellors JW, Albert J, Coffin JM, Palmer SE.
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule.
Proc Natl Acad Sci U S A. 2011 July 5;108(27):11199-204.

Tyagi S, Ochem A, Tyagi M.
DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression.
J Gen Virol. 2011 Jul;92(Pt 7):1710-20.


JUN 2011

Meade CS, Lowen SB, MacLean RR, Key MD, Lukas SE.
fMRI brain activation during a delay discounting task in HIV-positive adults with and without cocaine dependence.
Psychiatry Res. 2011 Jun 30;192(3):167-75.
READ MORE: Does Cocaine Increase the Threat of HIV?

Xing S, Bullen CK, Shroff NS, Shan L, Yang HC, Manucci JL, Bhat S, Zhang H, Margolick JB, Quinn TC, Margolis DM, Siliciano JD, Siliciano RF.
Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation.
J Virol. 2011 Jun;85(12):6060-4


APR 2011

Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG.
A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response.
J Infect Dis. 2011 Apr 1;203(7):960-8.

Meade CS, Conn NA, Skalski LM, Safren SA.
Neurocognitive impairment and medication adherence in HIV patients with and without cocaine dependence.
J Behav Med. 2011 Apr;34(2):128-38.

Celada MT, Merchant RC, Waxman MJ, Sherwin AM.
An Ethical Evaluation of the 2006 Centers for Disease Control and Prevention Recommendations for HIV Testing in Health Care Settings.
Am J Bioeth. 2011 Apr;11(4):31-40.
READ MORE: The Ethics of Universal HIV Screening

Monde K, Chukkapalli V, Ono A.
Assembly and Replication of HIV-1 in T Cells with Low Levels of Phosphatidylinositol-(4,5)-Bisphosphate
J. Virol. 2011;85 3584-3595

Sungkanuparph S, Oyomopito R, Sirivichayakul S, Sirisanthana T, Li PC, Kantipong P, Lee CK, Kamarulzaman A, Messerschmidt L, Law MG, Phanuphak P; on behalf of the TREAT Asia Studies to Evaluate Resistance-Monitoring Study (TASER-M). 
HIV-1 Drug Resistance Mutations Among Antiretroviral-Naive HIV-1-Infected Patients in Asia: Results From the TREAT Asia Studies to Evaluate Resistance-Monitoring Study.
Clin Infect Dis. 2011 Apr;52(8):1053-1057.

MAR 2011

Hendrix J, Gijsbers R, De Rijck J, Voet A, Hotta J, McNeely M, Hofkens J, Debyser Z, Engelborghs Y.
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering.
Nucleic Acids Res. 2011 Mar 1;39(4):1310-25.

Hunt PW, Hatano H, Sinclair E, Lee TH, Busch MP, Martin JN, McCune JM, Deeks SG.
HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers.
Clin Infect Dis. 2011 Mar;52(5):681-7.

Olesen R, Wahl A, Denton PW, Victor Garcia J.
Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection.
J Reprod Immunol. 2011 Mar;88(2):195-203.
READ MORE: Can “Humanized” Mice Advance HIV Prevention?


FEB 2011

Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM.
HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells.
Blood. 2011 Feb 17;117(7):2189-99.
READ MORE: Focusing on CD8: The “Other T Cell” in HIV Infection


JAN 2011

Bosque A, Planelles V.
Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells.
Methods. 2011 Jan;53(1):54-61.
READ MORE: In the Lab, Recreating HIV’s Hidden Reservoirs

Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, Emu B, Norris PJ, Busch MP, Martin JN, Brooks C, McCune JM, Deeks SG.
A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers.
PLoS One. 2011 Jan 31;6(1):e15924.

Thys W, De Houwer S, Demeulemeester J, Taltynov O, Vancraenenbroeck R, Gérard M, De Rijck J, Gijsbers R, Christ F, Debyser Z.
Interplay between HIV Entry and Transportin-SR2 Dependency.
Retrovirology. 2011 Jan 30;8(1):7.

Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS.
Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms.
J Virol. 2011 Jan;85(1):43-50.

Chomont N, Dafonseca S, Vandergeeten C, Ancuta P, Sékaly RP.
Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV.
Curr Opin HIV AIDS. 2011 Jan;6(1):30-6.

2010 Publications

DEC 2010

Ling B, Mohan M, Lackner AA, Green LC, Marx PA, Doyle LA, Veazey RS.
The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection.
J Infect Dis. 2010 Dec 15;202(12):1846-54.

Josefsson L, Dahl V, Palmer S.
Can HIV infection be eradicated through use of potent antiviral agents?
Curr Opin Infect Dis. 2010 Dec;23(6):628-32.


NOV 2010

Ferre AL, Hunt PW, McConnell DH, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.
HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses.
J Virol. 2010 Nov;84(21):11020-9.
READ MORE: The HIV “Elites:” Viral Controllers and Their Genes 


OCT 2010

De Rijck J, Bartholomeeusen K, Ceulemans H, Debyser Z, Gijsbers R.
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region.
Nucleic Acids Res. 2010 Oct;38(18):6135-47.

Boutwell CL, Rolland MM, Herbeck JT, Mullins JI, Allen TM.
Viral evolution and escape during acute HIV-1 infection.
J Infect Dis. 2010 Oct 15;202 Suppl 2:S309-14.
READ MORE: HIV vs. the Immune System: Early Viral Mutations May Hold Clues for Vaccine Development

Demogines A, East AM, Lee JH, Grossman SR, Sabeti PC, Paull TT, Sawyer SL.
Ancient and recent adaptive evolution of primate non-homologous end joining genes.
PLoS Genet. 2010 Oct 21;6(10):e1001169.

SEP 2010

Dinkins C, Arko-Mensah J, Deretic V.
Autophagy and HIV.
Semin Cell Dev Biol. 2010 Sep;21(7):712-8.

Mothes W, Sherer NM, Jin J, Zhong P.
Virus cell-to-cell transmission.
J Virol. 2010 Sep;84(17):8360-8.

Lassen KG, Wissing S, Lobritz MA, Santiago M, Greene WC.
Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif.
J Biol Chem. 2010 Sep 17;285(38):29326-35.

Arnott A, Jardine D, Wilson K, Gorry PR, Merlin K, Grey P, Law MG, Dax EM, Kelleher AD, Smith DE, McPhee DA; Pulse Study Team.
High viral fitness during acute HIV-1 infection.
PLoS One. 2010 Sep 9;5(9). pii: e12631.
READ MORE: The Changeable Fitness of HIV: Implications for Early Treatment

Rolland M, Carlson JM, Manocheewa S, Swain JV, Lanxon-Cookson E, Deng W, Rousseau CM, Raugi DN, Learn GH, Maust BS, Coovadia H, Ndung'u T, Goulder PJ, Walker BD, Brander C, Heckerman DE, Mullins JI.
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
PLoS One. 2010 Sep 1;5(9). pii: e12463.


AUG 2010

O'Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D.
Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations.
PLoS One. 2010 Aug 6;5(8):e12009.

Deeks SG, McCune JM.
Can HIV be cured with stem cell therapy?
Nat Biotechnol. 2010 Aug;28(8):807-10.
READ MORE: Gene Therapy and the Potential for an HIV Cure

Gwadz MV, Cleland CM, Quiles R, Nish D, Welch J, Michaels LS, Gonzalez JL, Ritchie AS, Leonard NR.
CDC HIV testing guidelines and the rapid and conventional testing practices of homeless youth.
AIDS Educ Prev. 2010 Aug;22(4):312-27.

Ha TH, Liu H, Liu H, Cai Y, Feng T.
Concurrent sexual partnerships among men who have sex with men in Shenzhen, China.
Sex Transm Dis. 2010 Aug;37(8):506-11.


JUL 2010

Ances BM, Christensen JJ, Teshome M, Taylor J, Xiong C, Aldea P, Fagan AM, Holtzman DM, Morris JC, Mintun MA, Clifford DB.
Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study.
Neurology. 2010 Jul 13;75(2):111-5.

Merchant RC, Waxman MJ.
HIV screening in health care settings: some progress, even more questions.
JAMA. 2010 Jul 21;304(3):348-9.
READ MORE: The Promise and Challenges of Universal HIV Screening


JUN 2010

Gupta K, Diamond T, Hwang Y, Bushman F, Van Duyne GD.
Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.
J Biol Chem. 2010 Jun 25;285(26):20303-15.

Javanbakht M, Guerry S, Gorbach PM, Stirland A, Chien M, Anton P, Kerndt PR.
Prevalence and correlates of heterosexual anal intercourse among clients attending public sexually transmitted disease clinics in Los Angeles County.
Sex Transm Dis. 2010 Jun;37(6):369-76.
READ MORE: Heterosexual Anal Sex: Implications for HIV Prevention

Eggink D, Melchers M, Wuhrer M, van Montfort T, Dey AK, Naaijkens BA, David KB, Le Douce V, Deelder AM, Kang K, Olson WC, Berkhout B, Hokke CH, Moore JP, Sanders RW.
Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function.
Virology. 2010 Jun 5;401(2):236-47.

Binley JM, Ban YE, Crooks ET, Eggink D, Osawa K, Schief WR, Sanders RW.
Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization.
J Virol. 2010 Jun;84(11):5637-55.


MAY 2010

Owen RE, Heitman JW, Hirschkorn DF, Lanteri MC, Biswas HH, Martin JN, Krone MR, Deeks SG, Norris PJ; NIAID Center for HIV/AIDS Vaccine Immunology.
HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses.
AIDS. 2010 May 15;24(8):1095-105.

Götte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SF.
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.
Biochim Biophys Acta. 2010 May;1804(5):1202-12.
READ MORE: New Insights into Old Drug Classes

APR 2010

Probasco JC, Deeks SG, Lee E, Hoh R, Hunt PW, Liegler T, Price RW, Spudich SS.
Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation.
AIDS. 2010 Apr 24;24(7):1001-5.

Deretic V.
Autophagy in infection.
Curr Opin Cell Biol. 2010 Apr;22(2):252-62.

Buzón MJ, Massanella M, Llibre JM, Esteve A, Dahl V, Puertas MC, Gatell JM, Domingo P, Paredes R, Sharkey M, Palmer S, Stevenson M, Clotet B, Blanco J, Martinez-Picado J.
HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.
Nat Med. 2010 Apr;16(4):460-5.
READ MORE: Reducing HIV Growth to Zero


MAR 2010

Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, Littman DR, Coffin JM, Hughes SH, Unutmaz D, Engelman A, KewalRamani VN.
Flexible use of nuclear import pathways by HIV-1.
Cell Host Microbe. 2010 Mar 18;7(3):221-33.
READ MORE: Keeping HIV Out of a Cell’s Nucleus

Gijsbers R, Ronen K, Vets S, Malani N, De Rijck J, McNeely M, Bushman FD, Debyser Z.
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.
Mol Ther. 2010 Mar;18(3):552-60.

Ono A.
Relationships between plasma membrane microdomains and HIV-1 assembly.
Biol Cell. 2010 Mar 25;102(6):335-50.

Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M.
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.
Cell Host Microbe. 2010 Mar 18;7(3):234-44.


FEB 2010

Gosselin A, Monteiro P, Chomont N, Diaz-Griffero F, Said EA, Fonseca S, Wacleche V, El-Far M, Boulassel MR, Routy JP, Sekaly RP, Ancuta P.
Peripheral blood CCR4+ CCR6+ and CXCR3+ CCR6+ CD4+ T cells are highly permissive to HIV-1 infection.
J Immunol. 2010 Feb 1;184(3):1604-16.
READ MORE: Defining the Key Targets of HIV Infection


JAN 2010

Ances BM, Greenberg JH, Detre JA.
Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response.
Brain Res. 2010 Jan 14;1309:19-28.

Denton PW, Krisko JF, Powell DA, Mathias M, Kwak YT, Martinez-Torres F, Zou W, Payne DA, Estes JD, Garcia JV.
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice.
PLoS One. 2010 Jan 21;5(1):e8829.
READ MORE: The Promise of PrEP: Using Antiretrovirals to Prevent HIV Infection


2009 Publications

DEC 2009

Michailidis E, Marchand B, Kodama EN, Singh K, Matsuoka M, Kirby KA, Ryan EM, Sawani AM, Nagy E, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG.

Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.
J Biol Chem. 2009 Dec 18;284(51):35681-91.
READ MORE: Surprising Keys to a New Anti-HIV Compound  


NOV 2009

Shao W, Kearney M, Maldarelli F, Mellors JW, Stephens RM, Lifson JD, KewalRamani VN, Ambrose Z, Coffin JM, Palmer SE.
RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.
Retrovirology. 2009 Nov 4;6:101.
READ MORE: Animal Model Enables Researchers to Track the Evolution of HIV

Jouvenet N, Simon SM, Bieniasz PD.
Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles.
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19114-9.

OCT 2009

Choi AI, Shlipak MG, Hunt PW, Martin JN, Deeks SG.
HIV-infected persons continue to lose kidney function despite successful antiretroviral therapy.
AIDS. 2009 Oct 23;23(16):2143-9.
READ MORE: HIV, HAART, and the Kidneys

Diaz-Griffero F, Qin XR, Hayashi F, Kigawa T, Finzi A, Sarnak Z, Lienlaf M, Yokoyama S, Sodroski J.
A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.
J Virol. 2009 Oct;83(20):10737-51.

Liu H, Feng T, Liu H, Feng H, Cai Y, Rhodes AG, Grusky O.
Egocentric networks of Chinese men who have sex with men: network components, condom use norms, and safer sex.
AIDS Patient Care STDS. 2009 Oct;23(10):885-93.

Etemad B, Fellows A, Kwambana B, Kamat A, Feng Y, Lee S, Sagar M.
Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection.
J Virol. 2009 Oct;83(19):9694-708.

Sayles JN, Wong MD, Kinsler JJ, Martins D, Cunningham WE.
The association of stigma with self-reported access to medical care and antiretroviral therapy adherence in persons living with HIV/AIDS.
J Gen Intern Med. 2009 Oct;24(10):1101-8.


SEP 2009

Ances BM, Sisti D, Vaida F, Liang CL, Leontiev O, Perthen JE, Buxton RB, Benson D, Smith DM, Little SJ, Richman DD, Moore DJ, Ellis RJ; HNRC group.
Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain.
Neurology. 2009 Sep 1;73(9):702-8.

Archin NM, Keedy KS, Espeseth A, Dang H, Hazuda DJ, Margolis DM.
Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors.
AIDS. 2009 Sep 10;23(14):1799-806.
READ MORE: In Search of a Cure: Working to Turn On HIV

Eggink D, Langedijk JP, Bonvin AM, Deng Y, Lu M, Berkhout B, Sanders RW.
Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.
J Biol Chem. 2009 Sep 25;284(39):26941-50.

Shehu-Xhilaga M, Rhodes D, Wightman F, Liu HB, Solomon A, Saleh S, Dear AE, Cameron PU, Lewin SR.
The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.
AIDS. 2009 Sep 24;23(15):2047-50.
READ MORE: In Search of a Cure: Working to Turn On HIV


AUG 2009

Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP.
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.
Nat Med. 2009 Aug;15(8):893-900.
READ MORE: Eradicating HIV—amfAR-Funded Researchers Shed New Light on HIV Persistence

Jin J, Sturgeon T, Weisz OA, Mothes W, Montelaro RC.
HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking.
PLoS One. 2009 Aug 7;4(8):e6551.

Liu H, Liu H, Cai Y, Rhodes AG, Hong F.
Money boys, HIV risks, and the associations between norms and safer sex: a respondent-driven sampling study in Shenzhen, China.
AIDS Behav. 2009 Aug;13(4):652-62.
READ MORE: Money Boys and the Spread of HIV in China


JUL 2009

Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, Federico M, Panganiban A, Vergne I, Deretic V.
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.
J Cell Biol. 2009 Jul 27;186(2):255-68.

Jin J, Sherer NM, Heidecker G, Derse D, Mothes W.
Assembly of the murine leukemia virus is directed towards sites of cell-cell contact.
PLoS Biol. 2009 Jul;7(7):e1000163.


JUN 2009

Hsue PY, Hunt PW, Schnell A, Kalapus SC, Hoh R, Ganz P, Martin JN, Deeks SG.
Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis.
AIDS. 2009 Jun 1;23(9):1059-67.
READ MORE: HIV, HAART, and the Heart

Deretic V, Levine B.
Autophagy, immunity, and microbial adaptations.
Cell Host Microbe. 2009 Jun 18;5(6):527-49.


MAY 2009

Bushman FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, König R, Bandyopadhyay S, Ideker T, Goff SP, Krogan NJ, Frankel AD, Young JA, Chanda SK.
Host cell factors in HIV replication: meta-analysis of genome-wide studies.
PLoS Pathog. 2009 May;5(5):e1000437.

Ince WL, Harrington PR, Schnell GL, Patel-Chhabra M, Burch CL, Menezes P, Price RW, Eron JJ Jr, Swanstrom RI.
Major coexisting human immunodeficiency virus type 1 env gene subpopulations in the peripheral blood are produced by cells with similar turnover rates and show little evidence of genetic compartmentalization.
J Virol. 2009 May;83(9):4068-80.

Herrera C, Cranage M, McGowan I, Anton P, Shattock RJ.
Reverse transcriptase inhibitors as potential colorectal microbicides.
Antimicrob Agents Chemother. 2009 May;53(5):1797-807.
READ MORE: Studying and Stopping Rectal Transmission of HIV

Keele BF, Li H, Learn GH, Hraber P, Giorgi EE, Grayson T, Sun C, Chen Y, Yeh WW, Letvin NL, Mascola JR, Nabel GJ, Haynes BF, Bhattacharya T, Perelson AS, Korber BT, Hahn BH, Shaw GM.
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.
J Exp Med. 2009 May 11;206(5):1117-34.
READ MORE: Studying and Stopping Rectal Transmission of HIV


APR 2009

Ances BM, Liang CL, Leontiev O, Perthen JE, Fleisher AS, Lansing AE, Buxton RB.
Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation.
Hum Brain Mapp. 2009 Apr;30(4):1120-32.

Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, Pollard RB, Yee HF Jr, Martin JN, Deeks SG, Shacklett BL.
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control.
Blood. 2009 Apr 23;113(17):3978-89.

Abrahams MR, Anderson JA, Giorgi EE, Seoighe C, Mlisana K, Ping LH, Athreya GS, Treurnicht FK, Keele BF, Wood N, Salazar-Gonzalez JF, Bhattacharya T, Chu H, Hoffman I, Galvin S, Mapanje C, Kazembe P, Thebus R, Fiscus S, Hide W, Cohen MS, Karim SA, Haynes BF, Shaw GM, Hahn BH, Korber BT, Swanstrom R, Williamson C; CAPRISA Acute Infection Study Team; Center for HIV-AIDS Vaccine Immunology Consortium.
Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.
J Virol. 2009 Apr;83(8):3556-67.

Loh L, Reece JC, Fernandez CS, Alcantara S, Center R, Howard J, Purcell DF, Balamurali M, Petravic J, Davenport MP, Kent SJ.
Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.
PLoS Pathog. 2009 Apr;5(4):e1000378.

Lassen KG, Lobritz MA, Bailey JR, Johnston S, Nguyen S, Lee B, Chou T, Siliciano RF, Markowitz M, Arts EJ.
Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.
PLoS Pathog. 2009 Apr;5(4):e1000377.

Meade CS, Hansen NB, Kochman A, Sikkema KJ.
Utilization of medical treatments and adherence to antiretroviral therapy among HIV-positive adults with histories of childhood sexual abuse.
AIDS Patient Care STDS. 2009 Apr;23(4):259-66.
READ MORE: Optimizing Adherence in Adult Survivors of Childhood Sexual Abuse



MAR 2009

Hatziioannou T, Ambrose Z, Chung NP, Piatak M Jr, Yuan F, Trubey CM, Coalter V, Kiser R, Schneider D, Smedley J, Pung R, Gathuka M, Estes JD, Veazey RS, KewalRamani VN, Lifson JD, Bieniasz PD.
A macaque model of HIV-1 infection.
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4425-9.
READ MORE: Monkeying Around With Genes Leads to Effective Simian Model

D'Orso I, Frankel AD.
Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex.
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3101-6.

Huthoff H, Autore F, Gallois-Montbrun S, Fraternali F, Malim MH.
RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.
PLoS Pathog. 2009 Mar;5(3):e1000330.

FEB 2009

Jouvenet N, Neil SJ, Zhadina M, Zang T, Kratovac Z, Lee Y, McNatt M, Hatziioannou T, Bieniasz PD.
Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.
J Virol. 2009 Feb;83(4):1837-44.
READ MORE: Tying Up HIV With Tetherin

Liu H, Feng T, Rhodes AG, Liu H.
Assessment of the Chinese version of HIV and homosexuality related stigma scales.
Sex Transm Infect. 2009 Feb;85(1):65-9.


JAN 2009

Haaland RE, Hawkins PA, Salazar-Gonzalez J, Johnson A, Tichacek A, Karita E, Manigart O, Mulenga J, Keele BF, Shaw GM, Hahn BH, Allen SA, Derdeyn CA, Hunter E.
Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1.
PLoS Pathog. 2009 Jan;5(1):e1000274.

Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E.
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.
J Mol Biol. 2009 Jan 23;385(3):693-713.

Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, Feng Y, Lee SJ, Lieberman J, Palliser D.
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.
Cell Host Microbe. 2009 Jan 22;5(1):84-94.
READ MORE:  The Promise of an Effective Vaginal Microbicide

Bontjer I, Land A, Eggink D, Verkade E, Tuin K, Baldwin C, Pollakis G, Paxton WA, Braakman I, Berkhout B, Sanders RW.
Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.
J Virol. 2009 Jan;83(1):368-83.

2008 Publications

DEC 2008

Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, Karn J.
Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency.
J Virol. 2008 Dec;82(24):12291-303.

Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF.
RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus.
J Virol. 2008 Dec;82(24):12145-53.


NOV 2008

Sanders RW, Hsu ST, van Anken E, Liscaljet IM, Dankers M, Bontjer I, Land A, Braakman I, Bonvin AM, Berkhout B.
Evolution rescues folding of human immunodeficiency virus-1 envelope glycoprotein GP120 lacking a conserved disulfide bond.
Mol Biol Cell. 2008 Nov;19(11):4707-16.


OCT 2008

Jiang Q, Zhang L, Wang R, Jeffrey J, Washburn ML, Brouwer D, Barbour S, Kovalev GI, Unutmaz D, Su L.
FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo.
Blood. 2008 Oct 1;112(7):2858-68.
READ MORE: Of Mice and Men: Using “Humanized” Mice to Fight HIV

SEP 2008

Diaz-Griffero F, Perron M, McGee-Estrada K, Hanna R, Maillard PV, Trono D, Sodroski J.
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.
Virology. 2008 Sep 1;378(2):233-42.

Sayles JN, Hays RD, Sarkisian CA, Mahajan AP, Spritzer KL, Cunningham WE.
Development and psychometric assessment of a multidimensional measure of internalized HIV stigma in a sample of HIV-positive adults.
AIDS Behav. 2008 Sep;12(5):748-58.
READ MORE:  Measuring Stigma in HIV/AIDS


AUG 2008

Zhang L, Li X, Ma J, Yu L, Jiang J, Cen S.
The incorporation of APOBEC3 proteins into murine leukemia viruses.
Virology. 2008 Aug 15;378(1):69-78.

Mahajan AP, Sayles JN, Patel VA, Remien RH, Sawires SR, Ortiz DJ, Szekeres G, Coates TJ.
Stigma in the HIV/AIDS epidemic: a review of the literature and recommendations for the way forward.
AIDS. 2008 Aug;22 Suppl 2:S67-79.
READ MORE:  Stigma and the “Spoiled Identity”


JUL 2008

Jouvenet N, Bieniasz PD, Simon SM.
Imaging the biogenesis of individual HIV-1 virions in live cells.
Nature. 2008 Jul 10;454(7201):236-40.
READ MORE: Mathilde Krim Fellow Makes Breakthrough Finding - Podcast

Liu W, Worobey M, Li Y, Keele BF, Bibollet-Ruche F, Guo Y, Goepfert PA, Santiago ML, Ndjango JB, Neel C, Clifford SL, Sanz C, Kamenya S, Wilson ML, Pusey AE, Gross-Camp N, Boesch C, Smith V, Zamma K, Huffman MA, Mitani JC, Watts DP, Peeters M, Shaw GM, Switzer WM, Sharp PM, Hahn BH.
Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees.
PLoS Pathog. 2008 Jul 4;4(7):e1000097.
READ MORE: Watch the Monkeys: Screening for New Retrovirus Outbreaks

Eggink D, Baldwin CE, Deng Y, Langedijk JP, Lu M, Sanders RW, Berkhout B.
Selection of T1249-resistant human immunodeficiency virus type 1 variants.
J Virol. 2008 Jul;82(13):6678-88.


JUN 2008

Keele BF, Tazi L, Gartner S, Liu Y, Burgon TB, Estes JD, Thacker TC, Crandall KA, McArthur JC, Burton GF.
Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.
J Virol. 2008 Jun;82(11):5548-61.

Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG.
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
J Virol. 2008 Jun;82(11):5398-407.

Unwalla HJ, Li H, Li SY, Abad D, Rossi JJ.
Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1.
Mol Ther. 2008 Jun;16(6):1113-9.
READ MORE: Attacking HIV Genetically


MAY 2008

Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM.
HIV-induced changes in T cell signaling pathways.
J Immunol. 2008 May 15;180(10):6490-500.
READ MORE: Dialing Down the T Cell

Des Jarlais DC.
Data and Public Health Decision Making on HIV Prevention in Injection Drug Users
J Urban Health. 2008 May; 85(3): 303–305.

Groot F, Welsch S, Sattentau QJ.
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.
Blood. 2008 May 1;111(9):4660-3.


APR 2008

Chiu YL, Greene WC.
The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements.
Annu Rev Immunol. 2008 Apr;26:317-353.

Diaz-Griffero F, Taube R, Muehlbauer SM, Brojatsch J.
Efficient production of HIV-1 viral-like particles in mouse cells.
Biochem Biophys Res Commun. 2008 Apr 11;368(3):463-9.

Benferhat R, Sanchez-Martinez S, Nieva JL, Briand JP, Hovanessian AG.
The immunogenic CBD1 peptide corresponding to the caveolin-1 binding domain in HIV-1 envelope gp41 has the capacity to penetrate the cell membrane and bind caveolin-1.
Mol Immunol. 2008 Apr;45(7):1963-75.

Weiler AM, Li Q, Duan L, Kaizu M, Weisgrau KL, Friedrich TC, Reynolds MR, Haase AT, Rakasz EG.
Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239.
J Virol. 2008 Apr;82(8):4154-8.
READ MORE: Stopping Sexual Transmission of HIV

Sayles JN, Hays RD, Sarkisian CA, Mahajan AP, Spritzer KL, Cunningham WE.
Development and Psychometric Assessment of a Multidimensional Measure of Internalized HIV Stigma in a Sample of HIV-positive Adults.
AIDS Behav. 2008 Apr 4.


MAR 2008

van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP.
Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.
Nat Med. 2008 Mar;14(3):266-74.
READ MORE: Controlling HIV, Naturally


FEB 2008

Lakhashe S, Tripathy S, Paranjape R, Bhattacharya J.
Evidence of a Novel B/C Recombinant Exhibiting Unique Breakpoints of Near Full-Length HIV Type 1 Genome from Northeastern India.
AIDS Res Hum Retroviruses. 2008 Feb;24(2):229-34.
READ MORE:  Know Your Enemy—amfAR Grantees Study HIV Mutation and Drug Resistance

Troyer RM, Lalonde MS, Fraundorf E, Demers KR, Kyeyune F, Mugyenyi P, Syed A, Whalen CC, Bajunirwe F, Arts EJ.
A Radiolabeled Oligonucleotide Ligation Assay Demonstrates the High Frequency of Nevirapine Resistance Mutations in HIV Type 1 Quasispecies of NVP-Treated and Untreated Mother-Infant Pairs from Uganda.
AIDS Res Hum Retroviruses. 2008 Feb;24(2):235-50.
READ MORE: Know Your Enemy—amfAR Grantees Study HIV Mutation and Drug Resistance


JAN 2008

Zhang L, Saadatmand J, Li X, Guo F, Niu M, Jiang J, Kleiman L, Cen S.
Function analysis of sequences in human APOBEC3G involved in Vif-mediated degradation.
Virology. 2008 Jan 5;370(1):113-21.
READ MORE: Man (and Woman) Versus Virus

Kerns JA, Emerman M, Malik HS.
Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein.
PLoS Genet. 2008 Jan;4(1):e21.
READ MORE: Man (and Woman) Versus Virus  

2007 Publications

DEC 2007

Sawyer SL, Emerman M, Malik HS.
Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals.
PLoS Pathog. 2007 Dec 21;3(12):e197

Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron PU, Lewin SR.
CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.|
Blood. 2007 Dec 15;110(13):4161-4.
READ MORE: New Insights into HIV Latency: Identifying Roadblocks to a Cure 


NOV 2007

Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M Jr, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, Hu SL, Coffin JM, Lifson JD, KewalRamani VN.
Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1
Drug Resistance in a Macaque Model for Antiretroviral Therapy
J. Virol. 2007;81 12145-12155

Chen P, Hübner W, Spinelli MA, Chen BK.
Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses.
J Virol. 2007 Nov;81(22):12582-95.

Hübner W, Chen P, Del Portillo A, Liu Y, Gordon RE, Chen BK.
Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1.
J Virol. 2007 Nov;81(22):12596-607.

CA McKnight, DC Des Jarlais, T Perlis, K Eigo, M Krim, M Ruiz, D Purchase, A Solberg, TD Mastro.
Syringe Exchange Programs --- United States, 2005.
MMWR, November 9, 2007 / 56(44);1164-1167.
READ MORE: Syringe Exchange Programs: A Key Component of HIV Prevention

Song C, Aiken C.
Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.
J Virol. 2007 Nov;81(21):11946-56.


OCT 2007

Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
EMBO J. 2007 Oct 3;26(19):4215-27.

Huffam S, Srasuebkul P, Zhou J, Calmy A, Saphonn V, Kaldor J, Ditangco R; on behalf of The TREAT Asia HIV Observational Database (TAHOD).
Prior antiretroviral therapy experience protects against zidovudine-related anaemia.
HIV Med. 2007 Oct;8(7):465-71.
READ MORE: Treating HIV/AIDS in Asia: Insights from amfAR's TREAT Asia Initiative

Voronin Y, Chohan B, Emerman M, Overbaugh J.
Primary isolates of human immunodeficiency virus type 1 are usually dominated by the major variants found in blood.
J Virol. 2007 Oct;81(19):10232-41.


SEP 2007

Roc AC, Ances BM, Chawla S, Korczykowski M, Wolf RL, Kolson DL, Detre JA, Poptani H.
Detection of human immunodeficiency virus induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite antiretroviral therapy.
Arch Neurol. 2007 Sep;64(9):1249-57.
READ MORE: Scanning the Brain

Dames SA, Schönichen A, Schulte A, Barboric M, Peterlin BM, Grzesiek S, Geyer M.
Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14312-14317

Gorry PR, McPhee DA, Verity E, Dyer WB, Wesselingh SL, Learmont J, Sullivan JS, Roche M, Zaunders JJ, Gabuzda D, Crowe SM, Mills J, Lewin SR, Brew BJ, Cunningham AL, Churchill MJ.
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo.
Retrovirology. 2007 Sep 23;4(1):66

Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL.
Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host.
J Immunol. 2007 Sep 1;179(5):3047-56.

Neil S.J.D, Sandrin V., Sundquist W.I., Bieniasz P.
An interferon-alpha induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by HIV-1 Vpu protein.
Cell Host & Microbe. (2007), Sep 2(3):193–203.

Simon Swingler, Angela M. Mann, Jin Zhou, Catherine Swingler, Mario Stevenson
Apoptotic Killing of HIV-1–Infected Macrophages Is Subverted by the Viral Envelope Glycoprotein
PLoS Pathog 2007 3(9): e134

Srasuebkul P, Calmy A, Zhou J, Kumarasamy N, Law M, Lim PL.
Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in The TREAT Asia HIV Observational Database (TAHOD).
AIDS Res Ther. 2007 Sep 17;4(1):18


AUG 2007

Bellamy-McIntyre AK, Lay CS, Baär S, Maerz AL, Talbo GH, Drummer HE, Poumbourios P.
Functional links between the fusion peptide-proximal polar segment and membrane-proximal region of human immunodeficiency virus gp41 in distinct phases of membrane fusion.
J Biol Chem. 2007 Aug 10;282(32):23104-16.
READ MORE: Building on amfAR-Funded Discoveries to Define Drug Targets

Pastore C, Nedellec R, Ramos A, Hartley O, Miamidian JL, Reeves JD, Mosier DE.
Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching.
J Virol. 2007 Aug;81(15):8165-79.
READ MORE: Building on amfAR-Funded Discoveries to Define Drug Targets

Zhou J, Dore GJ, Zhang F, Lim PL, Chen YM; The TREAT Asia HIV Observational Database.
Hepatitis B and C virus coinfection in The TREAT Asia HIV Observational Database.
J Gastroenterol Hepatol. 2007 Aug 15;22(9):1510-1518.


JUL 2007

Berthoux L, Sebastian S, Muesing MA, Luban J.
The role of lysine 186 in HIV-1 integrase multimerization.
Virology. 2007 Jul 20;364(1):227-36.

Gray L, Churchill MJ, Sterjovski J, Witlox K, Learmont JC, Sullivan JS, Wesselingh SL, Gabuzda D, Cunningham AL, McPhee DA, Gorry PR.
Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source.
Virol J. 2007 Jul 16;4(1):75
READ MORE: Long-Term Survivors of HIV

Zhou J, Paton NI, Ditangco R; The TREAT Asia HIV Observational Database.
AIDS-defining illness diagnosed within 90 days after starting highly active antiretroviral therapy among patients from the TREAT Asia HIV Observational Database.
Int J STD AIDS. 2007 Jul;18(7):446-52.

Morita E., Sandrin V., Alam S.L., Eckert D.M., Gygi S.P., Sundquist W.I.
Identification of Human MVB12 Proteins as ESCRT-I Subunits that Function in HIV Budding.
Cell Host & Microbe 2007 Jul 2(1): 41-53


JUN 2007

Mowry EM, Woo JH, Ances BM.
Baló's concentric sclerosis presenting as a stroke-like syndrome.
Nat Clin Pract Neurol. 2007 Jun;3(6):349-54.

Sailaja G, Skountzou I, Quan FS, Compans RW, Kang SM.
Human immunodeficiency virus-like particles activate multiple types of immune cells.
Virology. 2007 Jun 5;362(2):331-41.
READ MORE: Envisioning an AIDS Vaccine

Coskun AK, van Maanen M, Janka D, Stockton D, Stankiewicsz P, Yatsenko S, Sutton RE.
Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release.
Virology. 2007 Jun 5;362(2):283-93.


MAY 2007

Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe SM, Gabuzda D.
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Virology. 2007 May 25;362(1):163-78.

Ellery PJ, Tippett E, Chiu YL, Paukovics G, Cameron PU, Solomon A, Lewin SR, Gorry PR, Jaworowski A, Greene WC, Sonza S, Crowe SM.
The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo.
J Immunol. 2007 May 15;178(10):6581-9.
READ MORE: Uncovering New HIV Sanctuaries: Potential Roadblocks to a Cure


APR 2007

Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB.
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
J Virol. 2007 Apr;81(8):4033-43.
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines

Law M, Cardoso RM, Wilson IA, Burton DR.
Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy.
J Virol. 2007 Apr;81(8):4272-85.
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines

Huthoff H, Malim MH.
Identification of amino acid residues in APOBEC3G required for regulation by human immunodeficiency virus type 1 Vif and Virion encapsidation.
J Virol. 2007 Apr;81(8):3807-15.

Pohlmann S, Munch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, Stahl-Hennig C, Matz-Rensing K, Schneider T, Doms RW, Kirchhoff F.
A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
Virology. 2007 Apr 10;360(2):275-85.
READ MORE: amfAR Fellows Tackle AIDS Drugs, Vaccines

Zhang L, Kovalev GI, Su L.
HIV-1 infection and pathogenesis in a novel humanized mouse model.
Blood. 2007 Apr 1;109(7):2978-81.


MAR 2007

Tempalski B, Flom PL, Friedman SR, Des Jarlais DC, Friedman JJ, McKnight C, Friedman R.
Social and political factors predicting the presence of syringe exchange programs in 96 US metropolitan areas.
Am J Public Health. 2007 Mar;97(3):437-47.

Fang L, Landau NR.
Analysis of Vif-induced APOBEC3G degradation using an alpha-complementation assay.
Virology. 2007 Mar 1;359(1):162-9.
READ MORE: Minor Genes of HIV May Have a Major Role in its Therapy

Schrofelbauer B, Hakata Y, Landau NR.
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4130-5.
READ MORE: Minor Genes of HIV May Have a Major Role in its Therapy


FEB 2007

Alfadhli A, Huseby D, Kapit E, Colman D, Barklis E.
Human immunodeficiency virus type 1 matrix protein assembles on membranes as a hexamer.
J Virol. 2007 Feb;81(3):1472-8.

Bieniasz PD.
An intrinsic host defense against HIV-1 integration?
J Clin Invest. 2007 Feb;117(2):302-4
READ MORE: Integrase: A New Word in the Fight Against HIV

Cardoso RM, Brunel FM, Ferguson S, Zwick M, Burton DR, Dawson PE, Wilson IA.
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
J Mol Biol. 2007 Feb 2;365(5):1533-44.

Baek K, Brown RS, Birrane G, Ladias JA.
Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J Mol Biol. 2007 Feb 16;366(2):563-73.


JAN 2007

Mehandru S, Poles MA, Tenner-Racz K, Manuelli V, Jean-Pierre P, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M.
Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection.
J Virol. 2007 Jan;81(2):599-612.

J Zhou, NI Paton, R Ditangco, Y-MA Chen, A Kamarulzaman, N Kumarasamy, CKC Lee, PCK Li, TP Merati, P Phanuphak, S Pujari, A Vibhagool, F Zhang, J Chuah, KR Frost, DA Cooper, MG Law, on behalf of The TREAT Asia HIV Observational Database.
Experience with the use of a first-line regimen of stavudine, lamivudine and nevirapine in patients in the TREAT Asia HIV Observational Database.
HIV Medicine 8 (1), 8-16.
READ MORE: Treating HIV in Asia: Lessons from amfAR's TREAT Asia Program


2006 Publications

DEC 2006

Hakata Y, Landau NR.
Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains. J Biol Chem. 2006 Dec 1;281(48):36624-31.

Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P, Shet A, Low A, Mohri H, Boden D, Racz P, Markowitz M.
Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection.
PLoS Med. 2006 Dec 5;3(12):e484
READ MORE: The HAART—and Gut—Of Acute HIV Infection

Zhou J, Phanupak P, Kiertiburanakul S, Ditangco R, Kamarulzaman A, Pujary S; TREAT Asia HIV Observational Database.
Highly active antiretroviral treatment containing efavirenz or nevirapine and related toxicity in the TREAT Asia HIV Observational Database.
J Acquir Immune Defic Syndr. 2006 Dec 1;43(4):501-3.


NOV 2006

Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS.
Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clin Vaccine Immunol. 2006 Nov;13(11):1223-30.
READ MORE: Increasing the Potential of AIDS Vaccines: An amfAR Grantee Update

Kornbluth RS, Stone GW.
Immunostimulatory combinations: designing the next generation of vaccine adjuvants. J Leukoc Biol. 2006 Nov;80(5):1084-102.
READ MORE: Increasing the Potential of AIDS Vaccines: An amfAR Grantee Update

Meyer PR, Smith AJ, Matsuura SE, Scott WA.
Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants. Antimicrob Agents Chemother. 2006 Nov;50(11):3607-14.


OCT 2006

Ances BM, Letendre S, Buzzell M, Marquie-Beck J, Lazaretto D, Marcotte TD, Grant I, Ellis RJ; HNRC Group.
Valproic acid does not affect markers of human immunodeficiency virus disease progression.
J Neurovirol. 2006 Oct;12(5):403-6.

Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC.
High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition.
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15588-93.
READ MORE: Host Resistance Factors Preventing HIV Infection

Hatziioannou T, Princiotta M, Piatak M Jr, Yuan F, Zhang F, Lifson JD, Bieniasz PD.
Generation of simian-tropic HIV-1 by restriction factor evasion.
Science. 2006 Oct 6;314(5796):95.
READ MORE: Host Resistance Factors Preventing HIV Infection

Alimonti JB, Kimani J, Matu L, Wachihi C, Kaul R, Plummer FA, Fowke KR.
Characterization of CD8 T-cell responses in HIV-1-exposed seronegative commercial sex workers from Nairobi, Kenya.
Immunol Cell Biol. 2006 Oct;84(5):482-5.


SEP 2006

Holy A.
Antiviral acyclic nucleoside phosphonates structure activity studies.
Antiviral Res. 2006 Sep;71(2-3):248-53.
READ MORE: Designer Drugs For HIV

Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL.
Synthesis and Testing of a Focused Phenothiazine Library for Binding to HIV-1 TAR RNA.
Chem Biol. 2006 Sep;13(9):993-1000.
READ MORE: Designer Drugs For HIV


AUG 2006

Des Jarlais DC, Sloboda Z, Friedman SR, Tempalski B, McKnight C, Braine N.
Diffusion of the D.A.R.E and syringe exchange programs.
Am J Public Health. 2006 Aug;96(8):1354-8.

Valente ST, Goff SP.
Inhibition of HIV-1 gene expression by a fragment of hnRNP U.
Mol Cell. 2006 Aug;23(4):597-605.


JUL 2006

Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R, Luzuriaga K, Bell J, Simmonds P, Ball J, Clapham PR.
Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.
J Virol. 2006 Jul;80(13):6324-32
READ MORE: HIV and the Brain

Biscone MJ, Miamidian JL, Muchiri JM, Baik SS, Lee FH, Doms RW, Reeves JD.
Functional impact of HIV coreceptor-binding site mutations.
Virology. 2006 Jul 20;351(1):226-36.


JUN 2006

Barron MA, Blyveis N, Pan SC, Wilson CC.
Human Dendritic Cell Interactions with Whole Recombinant Yeast: Implications for HIV-1 Vaccine Development.
J Clin Immunol. 2006 May 13.

Bhattacharya J, Repik A, Clapham PR.
Gag regulates association of human immunodeficiency virus type 1 envelope with detergent-resistant membranes.
J Virol. 2006 Jun;80(11):5292-300.
READ MORE: Identifying Vulnerabilities in HIV as New Drug Targets

Schrofelbauer B, Senger T, Manning G, Landau NR.
Mutational Alteration of Human Immunodeficiency Virus Type 1 Vif Allows for Functional Interaction with Nonhuman Primate APOBEC3G.
J Virol. 2006 Jun;80(12):5984-91.


MAY 2006

Anand AR, Ganju RK.
HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.
J Biol Chem. 2006 May 5;281(18):12289-99.
READ MORE: Exploring How HIV Kills Cells of the Immune System


APR 2006

Biscone MJ, Miamidian JL, Muchiri JM, Baik SS, Lee FH, Doms RW, Reeves JD.
Functional impact of HIV coreceptor-binding site mutations.
Virology. 2006 Apr 19. [Epub ahead of print]
READ MORE: The Challenge of Drug-Resistant HIV

Coskun AK, van Maanen M, Nguyen V, Sutton RE.
Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1.
J Virol. 2006 Apr;80(7):3406-15.
READ MORE: Fighting HIV with Genetics


MAR 2006

Ambrose Z, Julias JG, Boyer PL, Kewalramani VN, Hughes SH.
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine.
J Virol. 2006 Mar;80(5):2578-81.

Chiu YL, Greene WC.
APOBEC3 Cytidine Deaminases: Distinct Antiviral Actions along the Retroviral Life Cycle.
J Biol Chem. 2006 Mar 31;281(13):8309-12.

Chen H, Lilley CE, Yu Q, Lee DV, Chou J, Narvaiza I, Landau NR, Weitzman MD.
APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.
Curr Biol. 2006 Mar 7;16(5):480-5.

Saphire AC, Gallay PA, Bark SJ.
Proteomic analysis of human immunodeficiency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins.
J Proteome Res. 2006 Mar;5(3):530-8.


FEB 2006

Brunel FM, Zwick MB, Cardoso RM, Nelson JD, Wilson IA, Burton DR, Dawson PE.
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
J Virol. 2006 Feb;80(4):1680-7.
READ MORE: amfAR Researchers Make Progress Towards an AIDS Vaccine

Stone GW, Barzee S, Snarsky V, Kee K, Spina CA, Yu XF, Kornbluth RS.
Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines.
J Virol. 2006 Feb;80(4):1762-72.
READ MORE: amfAR Researchers Make Progress Towards an AIDS Vaccine

JAN 2006

Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J.
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.
Nature. 2006 Jan 5;439(7072):89-94.
READ MORE: A Novel Strategy Against Sexually Transmitted Infections

2005 Publications

DEC 2005

Alfadhli A, Dhenub TC, Still A, Barklis E.
Analysis of human immunodeficiency virus type 1 Gag dimerization-induced assembly.
J Virol. 2005 Dec;79(23):14498-506. 

Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM.
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.
EMBO J. 2005 Dec 21;24(24):4291-303.

Blazek D, Barboric M, Kohoutek J, Oven I, Peterlin BM.
Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.
Nucleic Acids Res. 2005 Dec 23;33(22):7000-10.

Perez-Caballero D, Hatziioannou T, Zhang F, Cowan S, Bieniasz PD.
Restriction of Human Immunodeficiency Virus Type 1 by TRIM-CypA Occurs with Rapid Kinetics and Independently of Cytoplasmic Bodies, Ubiquitin, and Proteasome Activity
J Virol. 2005 Dec;79(24):15567-72.

Hsu M, Ho S, Balfe P, Gettie A, Harouse J, Blanchard J, Cheng-Mayer C.
A CCR5-Tropic Simian-HIV Molecular Clone Capable of Inducing AIDS in Rhesus Macaques.
JAIDS. 2005 Dec 1; 40(4):383-387.

Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC.
"Wide-Open" 1.3 A Structure of a Multidrug-Resistant HIV-1 Protease as a Drug Target.
Structure (Camb). 2005 Dec;13(12):1887-1895.

Sexton A, Drake PM, Mahmood N, Harman SJ, Shattock RJ, Ma JK.
Transgenic plant production of Cyanovirin-N, an HIV microbicide.
FASEB J. 2005 Dec 14;
READ MORE: Using Tobacco to Prevent HIV

Voronin Y, Overbaugh J, Emerman M.
Simian immunodeficiency virus variants that differ in pathogenicity differ in fitness under rapid cell turnover conditions.
J Virol. 2005 Dec;79(24):15091-8.


NOV 2005

Abner SR, Guenthner PC, Guarner J, Hancock KA, Cummins JE Jr, Fink A, Gilmore GT, Staley C, Ward A, Ali O, Binderow S, Cohen S, Grohskopf LA, Paxton L, Hart CE, Dezzutti CS.
A Human Colorectal Explant Culture to Evaluate Topical Microbicides for the Prevention of HIV Infection.
J Infect Dis. 2005 Nov 1;192(9):1545-56.


OCT 2005

Berthoux L, Sebastian S, Sokolskaja E, Luban J.
Cyclophilin A is required for TRIM5alpha-mediated resistance to HIV-1 in Old World monkey cells.
PNAS. 2005 Oct 11; 102(41):14849-14853.

Selvarajah S, Puffer B, Pantophlet R, Law M, Doms RW, Burton DR.
Comparing antigenicity and immunogenicity of engineered gp120.
J Virol. 2005 Oct;79(19):12148-63.

Arien KK, Troyer RM, Gali Y, Colebunders RL, Arts EJ, Vanham G.
Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time.
AIDS. 2005 Oct 14;19(15):1555-1564.
READ MORE: Studies Shed Light on Changes in HIV Virulence Over Time


SEP 2005

Barboric M, Zhang F, Besenicar M, Plemenitas A, Peterlin BM.
Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation.
J Virol. 2005 Sep;79(17):11135-41.

Reeves JD, Piefer AJ.
Emerging drug targets for antiretroviral therapy.
Drugs. 2005;65(13):1747-66.


AUG 2005

Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, Francois-Bongarcon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P.
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.
Blood. 2005 Aug 1;106(3):818-26. Epub 2005 Apr 14.

Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P.
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81. Epub 2005 Aug 4


JUL 2005

Schulte A, Czudnochowski N, Barboric M, Schonichen A, Blazek D, Peterlin BM, Geyer M.
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
J Biol Chem. 2005 Jul 1;280(26):24968-77.

Balasubramanian A, Koziel M, Groopman J, Ganju RK.
Molecular mechanism of hepatic injury in coinfection with hepatitis C virus and HIV.
Clin. Infect. Dis. 2005 Jul 1;41(Suppl 1):S32-37.

Perez-Caballero D, Hatziioannou T, Yang A, Cowan S, Bieniasz PD.
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.
J Virol. 2005 Jul;79(14):8969-78.

Troyer RM, Collins KR, Abraha A, Fraundorf E, Moore DM, Krizan RW, Toossi Z, Colebunders RL, Jensen MA, Mullins JI, Vanham G, Arts EJ.
Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression.
J Virol. 2005 Jul;79(14):9006-18.
READ MORE: Studies Shed Light on Changes in HIV Virulence Over Time


JUN 2005

Berthoux L, Sebastian S, Sayah DM, Luban J.
Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues.
Virol. 2005 Jun;79(12):7883-8.

Senkovich O, Speed H, Grigorian A, Bradley K, Ramarao CS, Lane B, Zhu G, Chattopadhyay D.
Crystallization of three key glycolytic enzymes of the opportunistic pathogen Cryptosporidium parvum.
Biochim Biophys Acta. 2005 Jun 10;

Marozsan AJ, Moore DM, Lobritz MA, Fraundorf E, Abraha A, Reeves JD, Arts EJ.
Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry.
J Virol. 2005 Jun;79(11):7121-34.


MAY 2005

Huseby D, Barklis RL, Alfadhli A, Barklis E.
Assembly of human immunodeficiency virus precursor gag proteins.
J Biol Chem. 2005 May 6;280(18):17664-70.

Chiu YL, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, Greene WC.
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells.
Nature. 2005 May 5;435(7038):108-14. Epub 2005 Apr 13.

Ylisastigui L, Kaur R, Johnson H, Volker J, He G, Hansen U, Margolis D.
Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter.
J Virol. 2005 May;79(10):5952-62.

Smith AJ, Meyer PR, Asthana D, Ashman MR, Scott WA.
Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations.
Antimicrob Agents Chemother. 2005 May;49(5):1761-9.


APR 2005

Schulte A, Czudnochowski N, Barboric M, Schonichen A, Blazek D, Peterlin BM, Geyer M.
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
J Biol Chem. 2005 Apr 25;

Dolakova P, Holy A, Zidek Z, Masojidkova M, Kmonickova E.
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives.
Bioorg Med Chem. 2005 Apr 1;13(7):2349-54.

Ibarrondo FJ, Anton PA, Fuerst M, Ng HL, Wong JT, Matud J, Elliott J, Shih R, Hausner MA, Price C, Hultin LE, Hultin PM, Jamieson BD, Yang OO.
Parallel human immunodeficiency virus type 1-specific CD8+ T-lymphocyte responses in blood and mucosa during chronic infection.
J Virol. 2005 Apr;79(7):4289-97.

Reeves JD, Lee FH, Miamidian JL, Jabara CB, Juntilla MM, Doms RW.
Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization.
J Virol. 2005 Apr;79(8):4991-9.


MARCH 2005

Chung E, Amrute SB, Abel K, Gupta G, Wang Y, Miller CJ, Fitzgerald-Bocarsly P.
Characterization of virus-responsive plasmacytoid dendritic cells in the rhesus macaque.
Clin Diagn Lab Immunol. 2005 Mar;12(3):426-35.

Navarro F, Bollman B, Chen H, Konig R, Yu Q, Chiles K, Landau NR.
Complementary function of the two catalytic domains of APOBEC3G.
Virology. 2005 Mar 15;333(2):374-86.


FEB 2005

Barboric M, Peterlin B.M.
A New Paradigm in Eukaryotic Biology: HIV Tat and the Control of Transcriptional Elongation.
PloS Biol. 3(2): e76

Cardoso RM, Zwick MB, Stanfield RL, Kunert R, Binley JM, Katinger H, Burton DR, Wilson IA.
Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41.
Immunity. 2005 Feb;22(2):163-73.
READ MORE: amfAR Fellows Make Important Leaps in Vaccine Research

Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC.
Structure of an unliganded simian immunodeficiency virus gp120 core.
Nature. 2005 Feb 24;433(7028):834-41.
READ MORE: amfAR Fellows Make Important Leaps in Vaccine Research

Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC.
Determining the Structure of an Unliganded and Fully Glycosylated SIV gp120 Envelope Glycoprotein.
Structure (Camb). 2005 Feb;13(2):197-211.

Lenz O, Dittmar MT, Wagner A, Ferko B, Vorauer-Uhl K, Stiegler G, Weissenhorn W.
Trimeric Membrane-anchored gp41 Inhibits HIV Membrane Fusion.
J Biol Chem. 2005 Feb 11;280(6):4095-4101. Epub 2004 Dec 1.

Zhou J, Kumarasamy N, Ditangco R, Kamarulzaman A, Lee CK, Li PC, Paton NI, Phanuphak P, Pujari S, Vibhagool A, Wong WW, Zhang F, Chuah J, Frost KR, Cooper DA, Law MG; TREAT Asia HIV Observational Database.
The TREAT Asia HIV Observational Database: baseline and retrospective data.
J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):174-9.


JAN 2005

Jones J, Kosloff BR, Benveniste EN, Shaw GM, Kutsch O.
Amphotericin-B-mediated reactivation of latent HIV-1 infection.
Virology. 2005 Jan 5;331(1):106-16.

Alimonti JB, Koesters SA, Kimani J, Matu L, Wachihi C, Plummer FA, Fowke KR.
CD4+ T cell responses in HIV-exposed seronegative women are qualitatively distinct from those in HIV-infected women.
J Infect Dis. 2005 Jan 1;191(1):20-4. Epub 2004 Dec 01.

Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD.
Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.
J Virol. 2005 Jan;79(1):176-83.

Hill M, Tachedjian G, Mak J.
The packaging and maturation of the HIV-1 Pol proteins.
Curr HIV Res. 2005 Jan;3(1):73-85.

*****Jones J, Kosloff BR, Benveniste EN, Shaw GM, Kutsch O.
Amphotericin-B-mediated reactivation of latent HIV-1 infection.
Virology. 2005 Jan 5;331(1):106-16.

2004 Publications

DEC 2004

Albright AV, Gonzalez-Scarano F.
Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression.
J Neuroimmunol. 2004 Dec;157(1-2):27-38.

Ambrose Z, Boltz V, Palmer S, Coffin JM, Hughes SH, Kewalramani VN.
In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques.
J Virol. 2004 Dec;78(24):13553-61.

Mehle A, Goncalves J, Santa-Marta M, McPike M, Gabuzda D.
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.
Genes Dev. 2004 Dec 1;18(23):2861-6.

De Berardinis P, Haigwood NL.
New recombinant vaccines based on the use of prokaryotic antigen-display systems.
Expert Rev Vaccines. 2004 Dec;3(6):673-9.

Yu Q, Chen D, Konig R, Mariani R, Unutmaz D, Landau NR.
APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.
J Biol Chem. 2004 Dec 17;279(51):53379-86. Epub 2004 Oct 04.

Francois-Bongarcon V, Feng Y, Lee SK, Chen G, Shankar P, Liu Y, Tao X, Shao Y, Lieberman J.
Cross-Clade CD8 T-Cell Responses to HIVIIIB and Chinese B' and C/B' Viruses in North American and Chinese HIV-Seropositive Donors.
J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1435-1444.


NOV 2004

Zerhouni B, Nelson JA, Saha K.
CXCR4-dependent infection of CD8+, but not CD4+, lymphocytes by a primary human immunodeficiency virus type 1 isolate.
J Virol. 2004 Nov;78(22):12288-96.


OCT 2004

Khan MZ, Brandimarti R, Patel JP, Huynh N, Wang J, Huang Z, Fatatis A, Meucci O.
Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis.
AIDS Res Hum Retroviruses. 2004 Oct;20(10):1063-71.

Meyer PR, Smith AJ, Matsuura SE, Scott WA.
Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.
J Biol Chem. 2004 Oct 29;279(44):45389-98. Epub 2004 Aug 11.

Pantophlet R, Wilson IA, Burton DR.
Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12.
Protein Eng Des Sel. 2004 Oct;17(10):749-58.